World Journal of Clinical Cases,
Год журнала:
2023,
Номер
11(6), С. 1236 - 1244
Опубликована: Фев. 21, 2023
Metabolic-associated
fatty
liver
disease
(MAFLD)
refers
to
the
build-up
of
fat
in
associated
with
metabolic
dysfunction
and
has
been
estimated
affect
a
quarter
population
worldwide.
Although
metabolism
is
highly
influenced
by
effects
sex
hormones,
studies
differences
incidence
progression
MAFLD
are
scarce.
Metabolomics
represents
powerful
approach
studying
these
identifying
potential
biomarkers
putative
mechanisms.
First,
metabolomics
makes
it
possible
obtain
molecular
phenotype
individual
at
given
time.
Second,
may
be
helpful
tool
for
classifying
patients
according
severity
obtaining
diagnostic
biomarkers.
Some
demonstrate
associations
between
circulating
metabolites
early
established
MAFLD,
but
little
known
about
how
relate
encompass
risk
management.
In
this
review,
we
will
discuss
epidemiological
metabolomic
development
role
profiles
understanding
mechanisms
sex-dependent
biomarkers,
evidence
help
future
management
disease.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 28, 2023
Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
is
among
the
most
widespread
metabolic
globally,
and
its
associated
complications
including
insulin
resistance
diabetes
have
become
threatening
conditions
for
human
health.
Previous
studies
on
non-alcoholic
(NAFLD)
were
focused
liver's
lipid
metabolism.
However,
growing
evidence
suggests
that
mitochondrial
metabolism
involved
in
pathogenesis
of
NAFLD
to
varying
degrees
several
ways,
instance
cellular
division,
oxidative
stress,
autophagy,
quality
control.
Ultimately,
function
gradually
declines
as
a
result
dysfunction.
The
unable
transfer
excess
droplets
outside
liver.
Therefore,
how
regulate
hepatic
treat
has
focus
current
research.
This
review
provides
details
about
intrinsic
link
with
mechanisms
by
which
dysfunctions
contribute
progression.
Given
crucial
role
progression,
application
potential
multiple
improvement
modalities
(including
physical
exercise,
diabetic
medications,
small
molecule
agonists
targeting
Sirt3,
mitochondria-specific
antioxidants)
treatment
was
evaluated
hoping
provide
new
insights
into
treatment.
Antioxidants,
Год журнала:
2023,
Номер
12(5), С. 1065 - 1065
Опубликована: Май 8, 2023
Together
with
the
global
rise
in
obesity
and
metabolic
syndrome,
prevalence
of
individuals
who
suffer
from
nonalcoholic
fatty
liver
disease
(NAFLD)
has
risen
dramatically.
NAFLD
is
currently
most
common
chronic
includes
a
continuum
disorders
initial
fat
accumulation
to
steatohepatitis
(NASH),
considered
more
severe
forms,
which
can
evolve
in,
cirrhosis,
hepatocellular
carcinoma.
Common
features
altered
lipid
metabolism
mainly
linked
mitochondrial
dysfunction,
which,
as
vicious
cycle,
aggravates
oxidative
stress
promotes
inflammation
and,
consequence,
progressive
death
hepatocytes
form
NAFLD.
A
ketogenic
diet
(KD),
i.e.,
very
low
carbohydrates
(<30
g/die)
that
induces
“physiological
ketosis”,
been
demonstrated
alleviate
restore
function.
Based
on
this,
aim
present
review
analyze
body
evidence
regarding
potential
therapeutic
role
KD
NAFLD,
focusing
interplay
between
mitochondria
liver,
effects
ketosis
pathways,
impact
Hepatology Communications,
Год журнала:
2024,
Номер
8(7)
Опубликована: Июль 1, 2024
With
an
increasing
prevalence,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
has
become
a
major
global
health
problem.
MASLD
is
well-known
as
multifactorial
disease.
Mitochondrial
dysfunction
and
alterations
in
the
gut
bacteria
are
2
vital
events
MASLD.
Recent
studies
have
highlighted
cross-talk
between
microbiota
mitochondria,
mitochondria
recognized
pivotal
targets
of
to
modulate
host's
physiological
state.
plays
role
associated
with
multiple
pathological
changes,
including
hepatocyte
steatosis,
oxidative
stress,
inflammation,
fibrosis.
Metabolites
crucial
mediators
that
influence
extraintestinal
organs.
Additionally,
regulation
composition
may
serve
promising
therapeutic
strategy
for
This
study
reviewed
potential
roles
several
common
metabolites
MASLD,
emphasizing
their
impact
on
mitochondrial
function.
Finally,
we
discuss
current
treatments
probiotics,
prebiotics,
antibiotics,
fecal
transplantation.
These
methods
concentrate
restoring
promote
host
health.
Abstract
Traditional
Chinese
medicine
(TCM)
has
been
widely
used
for
several
centuries
metabolic
diseases,
including
non-alcoholic
fatty
liver
disease
(NAFLD).
At
present,
NAFLD
become
the
most
prevalent
form
of
chronic
worldwide
and
can
progress
to
steatohepatitis
(NASH),
cirrhosis,
even
hepatocellular
carcinoma.
However,
there
is
still
a
lack
effective
treatment
strategies
in
Western
medicine.
The
development
driven
by
multiple
mechanisms,
genetic
factors,
insulin
resistance,
lipotoxicity,
mitochondrial
dysfunction,
endoplasmic
reticulum
stress,
inflammation,
gut
microbiota
dysbiosis,
adipose
tissue
dysfunction.
Currently,
certain
drugs,
sensitizers,
statins,
vitamin
E,
ursodeoxycholic
acid
betaine,
are
proven
be
beneficial
clinical
NAFLD.
Due
its
complex
pathogenesis,
personalized
that
integrates
various
mechanisms
may
provide
better
benefits
patients
with
holistic
view
syndrome
differentiation
TCM
have
advantages
treating
NAFLD,
which
similar
principles
In
TCM,
primarily
classified
into
five
types
based
on
experience.
It
located
closely
related
spleen
kidney
functions.
due
multi-component
characteristics
traditional
medicine,
application
considerably
limited.
this
review,
we
summarize
advances
pathogenesis
drawn
from
both
perspectives.
We
highlight
complementary
should
receive
increased
attention
prevention
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 20, 2024
Abstract
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
one
of
the
leading
causes
chronic
diseases,
affecting
more
than
one-quarter
people
worldwide.
Hepatic
steatosis
can
progress
to
severe
forms
NAFLD,
including
NASH
and
cirrhosis.
It
also
may
develop
secondary
diseases
such
as
diabetes
cardiovascular
disease.
Genetic
environmental
factors
regulate
NAFLD
incidence
progression,
making
it
a
complex
The
contribution
various
risk
factors,
type
2
diabetes,
obesity,
hyperlipidemia,
diet,
sedentary
lifestyle,
exacerbation
injury
highly
understood.
Nevertheless,
underlying
mechanisms
genetic
variations
in
occurrence
or
its
deterioration
still
need
be
clarified.
Hence,
understanding
susceptibility
essential
for
controlling
course
current
review
discusses
genetics’
role
pathological
pathways
lipid
glucose
metabolism,
insulin
resistance,
cellular
stresses,
immune
responses.
Additionally,
explains
components
induction
progression
lean
individuals.
Finally,
highlights
utility
knowledge
precision
medicine
early
diagnosis
treatment
patients.
