Sex dimorphism and metabolic profiles in management of metabolic-associated fatty liver disease DOI Open Access
María Martín-Grau, Daniel Monleón

World Journal of Clinical Cases, Journal Year: 2023, Volume and Issue: 11(6), P. 1236 - 1244

Published: Feb. 21, 2023

Metabolic-associated fatty liver disease (MAFLD) refers to the build-up of fat in associated with metabolic dysfunction and has been estimated affect a quarter population worldwide. Although metabolism is highly influenced by effects sex hormones, studies differences incidence progression MAFLD are scarce. Metabolomics represents powerful approach studying these identifying potential biomarkers putative mechanisms. First, metabolomics makes it possible obtain molecular phenotype individual at given time. Second, may be helpful tool for classifying patients according severity obtaining diagnostic biomarkers. Some demonstrate associations between circulating metabolites early established MAFLD, but little known about how relate encompass risk management. In this review, we will discuss epidemiological metabolomic development role profiles understanding mechanisms sex-dependent biomarkers, evidence help future management disease.

Language: Английский

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments DOI Creative Commons
Jun Guo, Xiuqing Huang, Lin Dou

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Language: Английский

Citations

700
Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy DOI Creative Commons

Youwei Zheng,

Shiting Wang,

Jialiang Wu

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 28, 2023

Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic globally, and its associated complications including insulin resistance diabetes have become threatening conditions for human health. Previous studies on non-alcoholic (NAFLD) were focused liver's lipid metabolism. However, growing evidence suggests that mitochondrial metabolism involved in pathogenesis of NAFLD to varying degrees several ways, instance cellular division, oxidative stress, autophagy, quality control. Ultimately, function gradually declines as a result dysfunction. The unable transfer excess droplets outside liver. Therefore, how regulate hepatic treat has focus current research. This review provides details about intrinsic link with mechanisms by which dysfunctions contribute progression. Given crucial role progression, application potential multiple improvement modalities (including physical exercise, diabetic medications, small molecule agonists targeting Sirt3, mitochondria-specific antioxidants) treatment was evaluated hoping provide new insights into treatment.

Language: Английский

Citations

52
Investigating the Link between Ketogenic Diet, NAFLD, Mitochondria, and Oxidative Stress: A Narrative Review DOI Creative Commons
Antonio Paoli, Giuseppe Cerullo

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1065 - 1065

Published: May 8, 2023

Together with the global rise in obesity and metabolic syndrome, prevalence of individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically. NAFLD is currently most common chronic includes a continuum disorders initial fat accumulation to steatohepatitis (NASH), considered more severe forms, which can evolve in, cirrhosis, hepatocellular carcinoma. Common features altered lipid metabolism mainly linked mitochondrial dysfunction, which, as vicious cycle, aggravates oxidative stress promotes inflammation and, consequence, progressive death hepatocytes form NAFLD. A ketogenic diet (KD), i.e., very low carbohydrates (<30 g/die) that induces “physiological ketosis”, been demonstrated alleviate restore function. Based on this, aim present review analyze body evidence regarding potential therapeutic role KD NAFLD, focusing interplay between mitochondria liver, effects ketosis pathways, impact

Language: Английский

Citations

41
A near-infrared fluorescent probe for monitoring abnormal mitochondrial viscosity in cancer and fatty-liver mice model DOI

Jing‐Jing Chao,

Hui Zhang, Zhiqiang Wang

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1242, P. 340813 - 340813

Published: Jan. 7, 2023

Language: Английский

Citations

36
Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis DOI
Sachin Sharma, Dounia Le Guillou, Jennifer Y. Chen

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(10), P. 662 - 678

Published: Sept. 7, 2023

Language: Английский

Citations

35
Liver endothelial cells in NAFLD and transition to NASH and HCC DOI
Rallia-Iliana Velliou, Aigli‐Ioanna Legaki, Polyxeni Nikolakopoulou

et al.

Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(11)

Published: Oct. 5, 2023

Language: Английский

Citations

25
MAFLD as part of systemic metabolic dysregulation DOI
Jing Zhao, Lu Liu,

Yingying Cao

et al.

Hepatology International, Journal Year: 2024, Volume and Issue: 18(S2), P. 834 - 847

Published: April 9, 2024

Language: Английский

Citations

15
Gut microbial metabolites in MASLD: Implications of mitochondrial dysfunction in the pathogenesis and treatment DOI Creative Commons
Ruhan Zhang, Zhaobo Yan, Huan Zhong

et al.

Hepatology Communications, Journal Year: 2024, Volume and Issue: 8(7)

Published: July 1, 2024

With an increasing prevalence, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major global health problem. MASLD is well-known as multifactorial disease. Mitochondrial dysfunction and alterations in the gut bacteria are 2 vital events MASLD. Recent studies have highlighted cross-talk between microbiota mitochondria, mitochondria recognized pivotal targets of to modulate host's physiological state. plays role associated with multiple pathological changes, including hepatocyte steatosis, oxidative stress, inflammation, fibrosis. Metabolites crucial mediators that influence extraintestinal organs. Additionally, regulation composition may serve promising therapeutic strategy for This study reviewed potential roles several common metabolites MASLD, emphasizing their impact on mitochondrial function. Finally, we discuss current treatments probiotics, prebiotics, antibiotics, fecal transplantation. These methods concentrate restoring promote host health.

Language: Английский

Citations

15
Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies DOI Creative Commons
Xin Ding, Xu He,

Bulang Tang

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 3, 2024

Abstract Traditional Chinese medicine (TCM) has been widely used for several centuries metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD become the most prevalent form of chronic worldwide and can progress to steatohepatitis (NASH), cirrhosis, even hepatocellular carcinoma. However, there is still a lack effective treatment strategies in Western medicine. The development driven by multiple mechanisms, genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, adipose tissue dysfunction. Currently, certain drugs, sensitizers, statins, vitamin E, ursodeoxycholic acid betaine, are proven be beneficial clinical NAFLD. Due its complex pathogenesis, personalized that integrates various mechanisms may provide better benefits patients with holistic view syndrome differentiation TCM have advantages treating NAFLD, which similar principles In TCM, primarily classified into five types based on experience. It located closely related spleen kidney functions. due multi-component characteristics traditional medicine, application considerably limited. this review, we summarize advances pathogenesis drawn from both perspectives. We highlight complementary should receive increased attention prevention

Language: Английский

Citations

12
Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches DOI Creative Commons
Seyedeh Kosar Mahmoudi,

Shadi Tarzemani,

Taha Aghajanzadeh

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 20, 2024

Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes chronic diseases, affecting more than one-quarter people worldwide. Hepatic steatosis can progress to severe forms NAFLD, including NASH and cirrhosis. It also may develop secondary diseases such as diabetes cardiovascular disease. Genetic environmental factors regulate NAFLD incidence progression, making it a complex The contribution various risk factors, type 2 diabetes, obesity, hyperlipidemia, diet, sedentary lifestyle, exacerbation injury highly understood. Nevertheless, underlying mechanisms genetic variations in occurrence or its deterioration still need be clarified. Hence, understanding susceptibility essential for controlling course current review discusses genetics’ role pathological pathways lipid glucose metabolism, insulin resistance, cellular stresses, immune responses. Additionally, explains components induction progression lean individuals. Finally, highlights utility knowledge precision medicine early diagnosis treatment patients.

Language: Английский

Citations

11