Metabolites,
Год журнала:
2022,
Номер
13(1), С. 40 - 40
Опубликована: Дек. 26, 2022
Periodontitis
is
a
microbially
driven,
host-mediated
disease
that
leads
to
loss
of
periodontal
attachment
and
resorption
bone.
It
associated
with
the
elevation
systemic
inflammatory
markers
presence
comorbidities.
Coronavirus
2019
(COVID-19)
contagious
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
Although
majority
patients
have
mild
symptoms,
others
experience
important
complications
can
lead
death.
After
spread
COVID-19
pandemic,
several
investigations
demonstrating
possible
relationship
between
periodontitis
been
reported.
In
addition,
both
seem
provoke
and/or
impair
cardiometabolic
such
as
cardiovascular
disease,
type
diabetes,
metabolic
syndrome,
dyslipidemia,
insulin
resistance,
obesity,
non-alcoholic
fatty
liver
neurological
neuropsychiatric
complications.
Therefore,
due
increasing
number
focusing
on
periodontitis-COVID-19
considering
an
association
might
cause,
this
review
aims
summarize
all
existing
emerging
evidence
regarding
link
axis
consequent
impairments.
Chronobiology International,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Янв. 6, 2025
Seven-day
actigraphy
was
performed
within
1
month
in
122
community-dwelling
adults
(mean
age
24.40
y,
31
(25.4%)
men)
the
same
city
of
Tyumen,
Russia.
Groups
with
different
COVID-19
status
(present,
COVID-19(+),
Bioscience Reports,
Год журнала:
2023,
Номер
43(8)
Опубликована: Июль 24, 2023
Abstract
SARS-CoV-2
(COVID-19)
exerts
profound
changes
in
the
kynurenine
(Kyn)
pathway
(KP)
of
tryptophan
(Trp)
metabolism
that
may
underpin
its
pathophysiology.
The
KP
is
main
source
vital
cellular
effector
NAD+
and
intermediate
metabolites
modulate
immune
neuronal
functions.
Trp
top
influenced
by
COVID-19.
Sixteen
studies
established
virus-induced
activation
mediated
mainly
induction
indoleamine
2,3-dioxygenase
(IDO1)
most
affected
tissues
IDO2
lung
increased
release
proinflammatory
cytokines
but
could
additionally
involve
flux
plasma
free
(TDO)
cortisol.
major
Kyn
metabolite
targeted
COVID-19
kynurenic
acid
(KA),
with
greatest
affinity
for
aryl
hydrocarbon
receptor
(AhR),
which
also
activated
AhR
initiates
two
important
series
events:
a
vicious
circle
involving
IDO1
induction,
KA
accumulation
further
activation,
poly
(ADP-ribose)
polymerase
(PARP)
leading
to
depletion
cell
death.
virus
deprives
host
inhibiting
biosynthetic
from
quinolinic
acid,
while
simultaneously
acquiring
promoting
synthesis
nicotinamide
salvage
pathway.
Additionally,
protective
effects
sirtuin
1
are
minimised
PARP
activation.
dysfunction
mood
neurological
disorders
acutely
during
‘long
COVID’.
More
potential
vaccination
therapy
on
required
exploration
therapeutic
strategies
modulation
proposed.
Advances in respiratory medicine,
Год журнала:
2024,
Номер
92(1), С. 96 - 109
Опубликована: Фев. 14, 2024
Long
COVID-19,
also
known
as
post-acute
sequelae
of
SARS-CoV-2
infection,
is
a
condition
where
individuals
who
have
recovered
from
the
acute
phase
COVID-19
continue
to
experience
range
symptoms
for
weeks
or
even
months
afterward.
While
it
was
initially
thought
primarily
affect
respiratory
system,
has
become
clear
that
can
involve
various
organs
and
systems,
including
endocrine
which
includes
pituitary
gland.
In
context
there
growing
understanding
potential
implications
The
virus
directly
gland,
leading
abnormalities
in
hormone
production
regulation.
This
result
such
fatigue,
changes
appetite,
mood
disturbances.
persistent
often
debilitating
following
may
be
explained
by
deficiencies
ACTH
Growth
Corticotropin
insufficiency
dysregulation
body’s
stress
response
lead
prolonged
feelings
stress,
disturbances
patients.
Simultaneously,
somatotropin
growth,
muscle
function,
energy
metabolism,
potentially
causing
weakness,
exercise
intolerance,
body
composition.
Recently,
some
authors
suggested
involvement
gland
Post
Syndrome.
exact
mechanisms
viral
action
on
infected
cells
remain
under
discussion,
but
inflammatory
autoimmune
are
implicated.
aim
our
study
will
review
main
complications
infection.
Moreover,
we
explain
possible
persistence
Current Issues in Molecular Biology,
Год журнала:
2022,
Номер
45(1), С. 33 - 50
Опубликована: Дек. 21, 2022
SARS-CoV-2
causes
the
complex
and
heterogeneous
illness
known
as
COVID-19.
The
disease
primarily
affects
respiratory
system
but
can
quickly
become
systemic,
harming
multiple
organs
leading
to
long-lasting
sequelae
in
some
patients.
Most
infected
individuals
are
asymptomatic
or
present
mild
symptoms.
Antibodies,
complement,
immune
cells
efficiently
eliminate
virus.
However,
20%
of
develop
severe
organ
failure.
Virus
replication
has
been
described
several
patients
who
died
from
COVID-19,
suggesting
a
compromised
response.
Immunodeficiency
autoimmunity
responsible
for
this
impairment
facilitate
viral
escape.
Mutations
IFN
signal
transduction
T
cell
activation
inadequate
response
young
individuals.
Autoantibodies
accountable
secondary
immunodeficiency
with
infection
prolonged
Antibodies
against
cytokines
(interferons
α,
γ
ω,
IL1β,
IL6,
IL10,
IL-17,
IL21),
chemokines,
nuclear
proteins
DNA,
anticardiolipin,
extracellular
have
reported.
type
titer
autoantibodies
depend
on
age
gender.
Organ-specific
Their
role
is
under
study.
Autoimmunity
should
be
screened
risk
factors
Zeitschrift für Neuropsychologie,
Год журнала:
2023,
Номер
34(2), С. 57 - 70
Опубликована: Май 24, 2023
Abstract:
Cognitive
sequelae
after
recovery
from
an
initial
COVID-19
disease
are
present
in
a
subset
of
affected
individuals,
coalescing
around
several
important
issues
such
as
effects
age,
severity,
comorbidities,
and
other
factors.
Some
neuropsychological
symptoms
appear
more
common
among
certain
patient
populations.
Comorbidities
may
complicate
assessment
well.
Hence,
we
need
guideline-based
evaluation
to
guide
rehabilitation.
Drawing
the
recent
revision
German
National
Guideline
for
Long-
Post-COVID
Syndrome
current
advances
international
guidance
on
assessment,
this
article
provides
practical
scientifically
informed
recommendations
individuals
recovering
coronavirus-related
diseases.
AJP Gastrointestinal and Liver Physiology,
Год журнала:
2023,
Номер
324(4), С. G322 - G328
Опубликована: Март 7, 2023
The
COVID-19
pandemic
has
resulted
in
the
infection
of
hundreds
millions
individuals
over
past
3
years,
coupled
with
deaths.
Along
these
more
acute
impacts
infection,
a
large
subset
patients
developed
symptoms
that
collectively
comprise
"postacute
sequelae
COVID-19"
(PASC,
also
known
as
long
COVID),
which
can
persist
for
months
and
maybe
even
years.
In
this
review,
we
outline
current
knowledge
on
role
impaired
microbiota-gut-brain
(MGB)
axis
signaling
development
PASC
potential
mechanisms
involved,
may
lead
to
better
understanding
disease
progression
treatment
options
future.
