Innate Immunity in Cardiovascular Diseases—Identification of Novel Molecular Players and Targets DOI Open Access
Wolfgang Poller, Bettina Heidecker, Enrico Ammirati

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(1), P. 335 - 335

Published: Jan. 1, 2023

During the past few years, unexpected developments have driven studies in field of clinical immunology. One driver immense impact was outbreak a pandemic caused by novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects immunological re-search into cardiovascular diseases. Here, we specifically focus on selected taking advantage advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics chemogenetics. First, discuss emerging relevance diagnostics for diseases, including those associated with COVID-19—with role inflammation cardiomyopathies arrhythmias. Second, consider newly identified interactions at organ system levels which affect pathogenesis. Thus, immune influences arising intestinal are moving towards therapeutic exploitation. Further, powerful new research tools enabled insight brain–immune unprecedented resolution. This latter line investigation emphasizes strength influence emotional stress—acting through defined brain regions—upon viral disorders. Several challenges need be overcome before full these far-reaching findings will hit arena.

Language: Английский

Higher vulnerability to poor circadian light hygiene in individuals with a history of COVID-19 DOI
Denis Gubin,

Yu. V. Boldyreva,

Oliver Stefani

et al.

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 6, 2025

Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) the same city of Tyumen, Russia. Groups with different COVID-19 status (present, COVID-19(+),

Language: Английский

Citations

2
The kynurenine pathway of tryptophan metabolism: a neglected therapeutic target of COVID-19 pathophysiology and immunotherapy DOI Open Access
Abdulla A.‐B. Badawy

Bioscience Reports, Journal Year: 2023, Volume and Issue: 43(8)

Published: July 24, 2023

Abstract SARS-CoV-2 (COVID-19) exerts profound changes in the kynurenine (Kyn) pathway (KP) of tryptophan (Trp) metabolism that may underpin its pathophysiology. The KP is main source vital cellular effector NAD+ and intermediate metabolites modulate immune neuronal functions. Trp top influenced by COVID-19. Sixteen studies established virus-induced activation mediated mainly induction indoleamine 2,3-dioxygenase (IDO1) most affected tissues IDO2 lung increased release proinflammatory cytokines but could additionally involve flux plasma free (TDO) cortisol. major Kyn metabolite targeted COVID-19 kynurenic acid (KA), with greatest affinity for aryl hydrocarbon receptor (AhR), which also activated AhR initiates two important series events: a vicious circle involving IDO1 induction, KA accumulation further activation, poly (ADP-ribose) polymerase (PARP) leading to depletion cell death. virus deprives host inhibiting biosynthetic from quinolinic acid, while simultaneously acquiring promoting synthesis nicotinamide salvage pathway. Additionally, protective effects sirtuin 1 are minimised PARP activation. dysfunction mood neurological disorders acutely during ‘long COVID’. More potential vaccination therapy on required exploration therapeutic strategies modulation proposed.

Language: Английский

Citations

19
Pituitary and SARS CoV-2: An unremitting conundrum DOI Open Access
Cristina Căpățînă, Cătălina Poiană, Maria Fleseriu

et al.

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101752 - 101752

Published: Feb. 27, 2023

Language: Английский

Citations

17
The Growing Understanding of the Pituitary Implication in the Pathogenesis of Long COVID-19 Syndrome: A Narrative Review DOI Creative Commons
Taïeb Ach,

Ben Haj Slama Nassim,

Gorchane Asma

et al.

Advances in respiratory medicine, Journal Year: 2024, Volume and Issue: 92(1), P. 96 - 109

Published: Feb. 14, 2024

Long COVID-19, also known as post-acute sequelae of SARS-CoV-2 infection, is a condition where individuals who have recovered from the acute phase COVID-19 continue to experience range symptoms for weeks or even months afterward. While it was initially thought primarily affect respiratory system, has become clear that can involve various organs and systems, including endocrine which includes pituitary gland. In context there growing understanding potential implications The virus directly gland, leading abnormalities in hormone production regulation. This result such fatigue, changes appetite, mood disturbances. persistent often debilitating following may be explained by deficiencies ACTH Growth Corticotropin insufficiency dysregulation body’s stress response lead prolonged feelings stress, disturbances patients. Simultaneously, somatotropin growth, muscle function, energy metabolism, potentially causing weakness, exercise intolerance, body composition. Recently, some authors suggested involvement gland Post Syndrome. exact mechanisms viral action on infected cells remain under discussion, but inflammatory autoimmune are implicated. aim our study will review main complications infection. Moreover, we explain possible persistence

Language: Английский

Citations

8
Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging DOI

Sergio Giunta,

Chiara Giordani, María De Luca

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 218, P. 111915 - 111915

Published: Feb. 13, 2024

Language: Английский

Citations

6
Glucocorticoids and COVID-19 DOI Open Access
Stefano Bruscoli, Pier Giorgio Puzzovio,

Maria Zaimi

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 185, P. 106511 - 106511

Published: Oct. 13, 2022

Language: Английский

Citations

28
Autoimmunity and Immunodeficiency in Severe SARS-CoV-2 Infection and Prolonged COVID-19 DOI Creative Commons
Jenny Valentina Garmendia, Alexis García, Claudia Valentina De Sanctis

et al.

Current Issues in Molecular Biology, Journal Year: 2022, Volume and Issue: 45(1), P. 33 - 50

Published: Dec. 21, 2022

SARS-CoV-2 causes the complex and heterogeneous illness known as COVID-19. The disease primarily affects respiratory system but can quickly become systemic, harming multiple organs leading to long-lasting sequelae in some patients. Most infected individuals are asymptomatic or present mild symptoms. Antibodies, complement, immune cells efficiently eliminate virus. However, 20% of develop severe organ failure. Virus replication has been described several patients who died from COVID-19, suggesting a compromised response. Immunodeficiency autoimmunity responsible for this impairment facilitate viral escape. Mutations IFN signal transduction T cell activation inadequate response young individuals. Autoantibodies accountable secondary immunodeficiency with infection prolonged Antibodies against cytokines (interferons α, γ ω, IL1β, IL6, IL10, IL-17, IL21), chemokines, nuclear proteins DNA, anticardiolipin, extracellular have reported. type titer autoantibodies depend on age gender. Organ-specific Their role is under study. Autoimmunity should be screened risk factors

Language: Английский

Citations

26
SARS-CoV-2 infection and its effects on the endocrine system DOI Open Access
Charlotte Steenblock, Nicole Toepfner, Felix Beuschlein

et al.

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101761 - 101761

Published: March 5, 2023

Language: Английский

Citations

16
Role of the microbiota-gut-brain axis in postacute COVID syndrome DOI
Mélanie G. Gareau, Kim E. Barrett

AJP Gastrointestinal and Liver Physiology, Journal Year: 2023, Volume and Issue: 324(4), P. G322 - G328

Published: March 7, 2023

The COVID-19 pandemic has resulted in the infection of hundreds millions individuals over past 3 years, coupled with deaths. Along these more acute impacts infection, a large subset patients developed symptoms that collectively comprise "postacute sequelae COVID-19" (PASC, also known as long COVID), which can persist for months and maybe even years. In this review, we outline current knowledge on role impaired microbiota-gut-brain (MGB) axis signaling development PASC potential mechanisms involved, may lead to better understanding disease progression treatment options future.

Language: Английский

Citations

13
Improving Neuropsychological Rehabilitation for COVID-19 Patients DOI Creative Commons
Catherine Widmann, Juliana Kolano, Martin Peper

et al.

Zeitschrift für Neuropsychologie, Journal Year: 2023, Volume and Issue: 34(2), P. 57 - 70

Published: May 24, 2023

Abstract: Cognitive sequelae after recovery from an initial COVID-19 disease are present in a subset of affected individuals, coalescing around several important issues such as effects age, severity, comorbidities, and other factors. Some neuropsychological symptoms appear more common among certain patient populations. Comorbidities may complicate assessment well. Hence, we need guideline-based evaluation to guide rehabilitation. Drawing the recent revision German National Guideline for Long- Post-COVID Syndrome current advances international guidance on assessment, this article provides practical scientifically informed recommendations individuals recovering coronavirus-related diseases.

Language: Английский

Citations

13