Children,
Год журнала:
2025,
Номер
12(3), С. 343 - 343
Опубликована: Март 9, 2025
Objectives:
The
aim
was
to
simultaneously
investigate
inflammatory
biomarkers,
neopterin,
the
kynurenine/tryptophan
(Kyn/Trp)
pathway,
vitamin
D
(VitD),
binding
protein
(VDBP),
and
erythrocyte
folate,
in
cerebral
palsy
(CP).
Methods:
A
case–control
study
conducted
at
Mersin
University
Hospital.
Three-
ten-year-old
patients
with
spastic
CP
(n
=
50)
age-
gender-matched
healthy
controls
55)
were
included.
Serum
levels
of
Trp,
Kyn
25OHD,
plasma
VDBP,
folate
concentrations
measured.
Indoleamine-2,3-dioxygenase
1
(IDO-1)
enzyme
activity
evaluated
according
Kyn/Trp
ratio.
Comparison
correlation
analyses
performed.
Results:
lower
children
than
(p
0.037,
p
<
0.001,
0.003,
respectively).
IDO1
not
significantly
different
between
control
groups
0.214).
VitD
VDBP
higher
0.001
level
also
0.001).
No
significant
found
age
biomarkers
group.
Neopterin
correlated
Gross
Motor
Function
Classification
System
(GMFCS)
(r
0.292,
0.044),
while
there
no
other
GMFCS
Conclusions:
Inflammatory
neopterin
are
lower,
higher,
anti-inflammatory
is
compared
children.
More
knowledge
needed
demonstrate
status
CP.
Reviews in the Neurosciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 5, 2024
Major
depressive
disorder
(MDD)
is
a
prevalent
psychiatric
that
has
damage
to
people's
quality
of
life.
Tryptophan
the
precursor
serotonin,
critical
neurotransmitter
in
mood
modulation.
In
mammals,
most
free
tryptophan
degraded
by
kynurenine
pathway
(KP),
resulting
range
metabolites
involved
inflammation,
immune
response,
and
neurotransmission.
The
imbalance
between
quinolinic
acid
(QA),
toxic
metabolite,
kynurenic
(KynA),
protective
relevant
phenomenon
pathophysiology
MDD.
Proinflammatory
cytokines
increase
activity
enzyme
indoleamine
2,3-dioxygenase
(IDO),
leading
degradation
KP
an
release
QA.
IDO
activates
proinflammatory
genes,
potentiating
neuroinflammation
deregulating
other
physiological
mechanisms
related
chronic
stress
This
review
highlights
with
MDD,
which
are
underlying
discuss
potential
therapeutic
targets.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Май 5, 2023
Psychological
stress
can
induce
affective
disorders.
Gut
microbiota
plays
a
vital
role
in
emotional
function
regulation;
however,
the
association
between
gut
and
psychological
is
poorly
understood.
We
investigated
effects
of
on
microbiome
fecal
metabolites
assessed
relationship
disorder
behavior
altered
microbiota.A
model
was
established
C57BL/6J
mice
using
communication
box.
Sucrose
preference
test,
forced
swim
open
field
test
helped
assess
anxiety-
depression-like
behaviors.
Fecal
transplantation
(FMT)
conducted
samples
from
stressed
non-stressed
mice.
Moreover,
16S
rRNA
gene
sequencing
untargeted
metabolomics
were
performed.After
exposure
for
14
days,
significant
increase
behaviors
observed.
FMT
"affective
microbiota"
psychologically
increased
sensitivity
relative
to
"normal
revealed
decreased
abundance
Bacteroides,
Alistipes,
Lactobacillus
Parasutterella
Rikenellaceae_RC9_gut_group
mice;
furthermore,
showed
differential
metabolite
profiles.
KEGG
pathway
analysis
indicated
that
chiefly
involved
downregulated
pathways
α-linolenic
acid
metabolism,
taste
transduction,
galactose
metabolism.
Alistipes
Bacteroides
mainly
positively
correlated
negatively
with
diverse
metabolites.Our
findings
suggest
dysbiosis
contributes
development
response
stress.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 8, 2023
The
present
work
aimed
to
identify
probiotic
candidates
from
Lithuanian
homemade
fermented
food
samples.
A
total
of
23
lactic
acid
bacteria
were
isolated
different
Among
these,
only
12
showed
resistance
low
pH,
tolerance
pepsin,
bile
salts,
and
pancreatin.
strains
also
exhibited
antimicrobial
activity
against
Staphylococcus
aureus
ATCC
29213,
Salmonella
Typhimurium
14028,
Streptococcus
pyogenes
12384,
19615,
Klebsiella
pneumoniae
13883.
Cell-free
supernatants
isolate
3A
55w
the
strongest
antioxidant
26.37
μg/mL
26.06
μg/mL,
respectively.
Isolate
11w
auto-aggregation
ability
79.96%
as
well
adhesion
HCT116
colon
cells
(25.671
±
0.43%).
selected
tested
for
their
synbiotic
relation
in
presence
a
prebiotic.
high
proliferation
4%
compared
2%
galactooligosaccharides.
tryptophan
production
ability,
produced
highest
L-tryptophan
levels
16.63
2.25
μm,
exhibiting
psychobiotic
safety
these
was
studied
by
ascertaining
antibiotic
susceptibility,
mucin
degradation,
gelatin
hydrolysis,
hemolytic
activity.
In
all,
isolates
40C
demonstrated
most
desirable
potentials
identified
16S
RNA
later
confirmed
whole
genome
sequencing
Lacticaseibacillus
paracasei
11w,
Lactiplantibacillus
plantarum
40C:
following
with
harboring
plasmid
investigation.
Out
all
strains,
potential
properties.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2737 - 2737
Опубликована: Фев. 1, 2023
Addiction,
the
continuous
misuse
of
addictive
material,
causes
long-term
dysfunction
in
neurological
system.
It
substantially
affects
control
strength
reward,
memory,
and
motivation.
Addictive
substances
(alcohol,
marijuana,
caffeine,
heroin,
methamphetamine
(METH),
nicotine)
are
highly
active
central
nervous
stimulants.
Addiction
leads
to
severe
health
issues,
including
cardiovascular
diseases,
serious
infections,
pulmonary/dental
diseases.
Drug
dependence
may
result
unfavorable
cognitive
impairments
that
can
continue
during
abstinence
negatively
influence
recovery
performance.
Although
addiction
is
a
critical
global
challenge
with
numerous
consequences
complications,
currently,
there
no
efficient
options
for
treating
drug
addiction,
particularly
METH.
Currently,
novel
treatment
approaches
such
as
psychological
contingency
management,
behavioral
therapy,
motivational
enhancement
strategies
great
interest.
Herein,
we
evaluate
devastating
impacts
different
substances/drugs
on
users'
mental
role
tryptophan
alleviating
side
effects.
The
metabolites
mammalian
brain
their
potential
treat
compulsive
abuse
investigated
by
assessing
functional
effects
tryptophan.
Future
perspectives
developing
promising
modalities
its
alleviate
dependency
discussed.
Pharmaceutics,
Год журнала:
2024,
Номер
16(1), С. 84 - 84
Опубликована: Янв. 8, 2024
Addiction,
particularly
in
relation
to
psychostimulants
and
opioids,
persists
as
a
global
health
crisis
with
profound
social
economic
ramifications.
Traditional
interventions,
including
medications
behavioral
therapies,
often
encounter
limited
success
due
the
chronic
relapsing
nature
of
addictive
disorders.
Consequently,
there
is
significant
interest
development
innovative
therapeutics
counteract
effects
abused
substances.
In
recent
years,
vaccines
have
emerged
novel
promising
strategy
tackle
addiction.
Anti-drug
are
designed
stimulate
immune
system
produce
antibodies
that
bind
compounds,
such
nicotine,
cocaine,
morphine,
methamphetamine,
heroin.
These
effectively
neutralize
target
molecules,
preventing
them
from
reaching
brain
eliciting
their
rewarding
effects.
By
obstructing
sensations
associated
substance
use,
aim
reduce
cravings
motivation
engage
drug
use.
Although
anti-drug
hold
potential,
challenges
remain
implementation.
The
reversibility
vaccination
potential
for
combining
other
addiction
treatments
offer
promise
improving
outcomes.
This
review
provides
an
overview
vaccines,
mechanisms
action,
impact
on
treatment
use
Furthermore,
this
summarizes
advancements
vaccine
each
specific
drug,
offering
insights
more
effective
personalized
capable
addressing
distinct
posed
by
various
OBM Neurobiology,
Год журнала:
2024,
Номер
08(01), С. 1 - 22
Опубликована: Янв. 11, 2024
In
the
last
decade,
development
in
nanotechnology
has
been
used
intensively.
By
studying
and
nanomaterials,
we
can
generate
excellent
responses
healthcare
related
to
neurological
disorders.
It
also
includes
easy
diagnosis
of
diseases
their
early
stages,
delivery
genes,
many
more.
Neurological
disorders
are
one
most
sensitive
topics.
Therefore,
nanomaterials
promise
treat
as
they
highly
efficient.
Nanomaterials
will
significantly
expand
our
knowledge
how
disease
originates
nervous
system
so
that
diagnose
its
stages.
This
review
describe
an
overview
paper
present
utilization
with
help
recent
data
current
research.
focus
on
significant
importance
toxicology
neurology.
deal
different
applications
studies
impact
developing
new
types
treatment
for
Lastly,
this
discuss
all
challenges
face
promises
future
vast
field.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 976 - 976
Опубликована: Янв. 24, 2025
The
cuprizone
(CPZ)
model
of
multiple
sclerosis
(MS)
is
excellent
for
studying
the
molecular
differences
behind
damage
caused
by
poisoning.
Metabolic
in
kynurenine
pathway
(KP)
tryptophan
(TRP)
degradation
are
observed
both
MS
and
a
CPZ
mouse
model.
Our
goal
was
to
analyze
kynurenine,
serotonin,
indole
pathways
TRP
on
periphery,
neurodegenerative
processes
inflammation.
In
our
study,
mice
were
fed
with
0.2%
toxin
5
weeks.
We
examined
metabolites
three
breakdown
urine,
plasma,
relevant
visceral
organs
bioanalytical
measurements.
analyses,
we
found
significant
increase
plasma
TRP,
5-hydroxytryptophan
(5-HTP),
indole-3-acetic
acid
(IAA)
levels,
while
decrease
concentrations
3-hydroxy-L-kynurenine
(3-HK),
xanthurenic
(XA),
kynurenic
(KYNA),
quinaldic
toxin-treated
group
found.
A
marked
levels
3-HK,
XA,
KYNA,
acid,
indole-3-lactic
also
end
Furthermore,
noticed
urinary
XA
metabolites,
an
serotonin
5-hydroxyindoleacetic
noticed.
treatment
resulted
elevated
tryptamine
indoxyl
sulfate
reduced
IAA
concentration.
Moreover,
para-cresyl
concentration
increased
treated
group.
present
showed
main
metabolic
confirmed
relationship
correlation
between
content
tissues
organs.
emphasized
suppression
KP
activity
particular
regard
involvement
microbiome
pathway.
Consequently,
this
first
study
detail
distribution
periphery.
