Russian Journal of Bioorganic Chemistry, Год журнала: 2024, Номер 50(6), С. 2240 - 2251
Опубликована: Дек. 1, 2024
Язык: Английский
Food Chemistry Advances, Год журнала: 2023, Номер 2, С. 100239 - 100239
Опубликована: Март 13, 2023
Язык: Английский
Процитировано
50
Phytomedicine Plus, Год журнала: 2023, Номер 3(4), С. 100501 - 100501
Опубликована: Ноя. 1, 2023
: Resveratrol (RVL) is a polyphenol-containing natural product found in variety of plants, including peanuts, grapes, and berry fruits. The use RVL linked great deal research to number therapeutic properties. In an attempt improve these properties, five RVL-based coumarins, abbreviated YF1-YF5, were synthesized structurally constructed pathway. molecular architecture our coumarins was confirmed by analyzing their FTIR NMR spectra. biomedical effects the investigated compared with precursor. first dual 5-LOX/COX inhibitory effect, which tested versus three related enzymes. second free-radical neutralizing estimated against two radical phenotypes. third apoptotic-inducing evaluated four tumorous cell lines. fourth high blood-glucose regulatory effect assessed corresponding Finally, bacterial growth-suppressing pathogenic strains. pharmacokinetic identifiers compounds also silico matched analyze chemical functionalization. findings indicated that exhibited enhanced building moiety. best reported for YF3, lowest attributed YF5. This improvement coupled advancements identifiers. According outcomes, authors concluded provide intriguing modification improving its effects.
Язык: Английский
Процитировано
38
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116294 - 116294
Опубликована: Фев. 23, 2024
Lung cancer, a leading global cause of mortality, poses significant public health challenge primarily linked to tobacco use. While contributes over 90% cases, factors like dietary choices and radiation exposure also play role. Despite potential benefits from early detection, cancer patients face hurdles, including drug resistance, chemotherapy side effects, high treatment costs, limited healthcare access. Traditional medicinal plant knowledge has recently unveiled diverse chemopreventive agents terrestrial marine sources. These phytochemicals regulate intricate molecular processes, influencing the immune system, apoptosis, cell cycle, proliferation, carcinogen elimination, antioxidant levels. In pursuing cutting-edge strategies combat forms technological advancements have spurred innovative approaches. Researchers focused on green synthesis metallic nanoparticles using metabolites. This method offers distinct advantages conventional physical chemical techniques, such as cost-effectiveness, biocompatibility, energy efficiency. Metallic nanoparticles, through various pathways generation reactive oxygen species, modulation enzyme activity, DNA fragmentation, disruption signaling pathways, perturbation membranes, interference with mitochondrial function resulting in damage, cycle arrest, exhibit for preventive applications. Thus, amalgamation phytocompounds holds promise novel approach lung therapy. However, further refinements are necessary enhance environmentally friendly process nanoparticle synthesis.
Язык: Английский
Процитировано
11
Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 598 - 598
Опубликована: Май 8, 2024
In the current work, synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of preclinical research findings. The prognosis for lung cancer patients poor, with a 5-year survival rate 18.1%. use combination has gained significant attention as potential novel approach treatment cancer. present work highlights importance finding more effective therapies to increase rates. Chemotherapy primary option but it limitations such reduced effectiveness because cells become resistant. Natural isolated from medicinal plants have shown promising anticancer or chemopreventive properties their synergistic effect been observed when combined therapies. an anti-cancer drug compound exhibits effects, enhancing overall therapeutic actions against cells. conclusion, this provides overview latest on plant-derived alternative complementary options chemotherapy discusses treating minimal side effects.
Язык: Английский
Процитировано
11
Plants, Год журнала: 2024, Номер 13(16), С. 2295 - 2295
Опубликована: Авг. 18, 2024
In recent years, the supercritical CO
Язык: Английский
Процитировано
11
Advances in Redox Research, Год журнала: 2024, Номер 13, С. 100113 - 100113
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
9
Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 100991 - 100991
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7863 - 7863
Опубликована: Апрель 26, 2023
Phytochemicals are chemical compounds that exist in plants and serve various functions such as protecting against pests, UV radiation, diseases [...].
Язык: Английский
Процитировано
20
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 22, 2024
Cancer refers to the proliferation and multiplication of aberrant cells inside human body, characterized by their capacity proliferate infiltrate various anatomical regions. Numerous biochemical pathways signaling molecules have an impact on cancer auto biogenesis process. The regulation crucial cellular processes necessary for cell survival proliferation, which are triggered phytochemicals, is significantly influenced pathways. These or components regulated phytochemicals. Medicinal plants a significant reservoir diverse anticancer medications employed in chemotherapy. effects phytochemicals mediated several methods, including induction apoptosis, cessation cycle, inhibition kinases, prevention carcinogenic substances. This paper analyzes phytochemistry seven prominent plant constituents, namely, alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, saponins, focusing involvement MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, actin dynamics. Hence, this review has examined range encompassing structural characteristics potential mechanisms. It underscored significance plant-derived bioactive compounds cancer, utilizing molecular In addition, endeavor also seeks incentivize scientists carry out clinical trials derived from plants.
Язык: Английский
Процитировано
7
Pharmacognosy Journal, Год журнала: 2024, Номер 15(6), С. 1105 - 1111
Опубликована: Янв. 1, 2024
Cancer is regarded as a nightmare for humanity and challenging task medical professionals. Twelve hydrides (2a-2l), made of trifunctionalized coumarin various substituted indoles, were created in an effort to realize the hope cancer cure. The 4,5-dimethoxysalicylaldehyde ethyl acetoacetate combined Knoevenagel reaction create component. construction indole component involved converting aminoindoles through diazotization Sandmeyer reactions twelve indoles (1a-1l). These two components Michael addition desired hybrids. Investigating their spectra released from spectroscopical instruments allowed researchers determine 2D molecular frameworks these Studying survival nine tumor cell types after treatment with synthesized hybrids enabled estimate there vitro impact cytotoxic candidates. By checking viability using MTT marker, it was possible see that this effect antiproliferative. cytotoxicity measurements, IC50 scores, revealed number intriguing facts. To start, synthetic displayed relatively similar pattern against cancerous lines under investigation. Second, compared chloride, hydroxyl, or methoxy substituents, fluorinated are more toxic cells. Finally, at position-6 (2i-2l) have highest among those functionalized position-4 (2a-2d) position-5 (2e-2h). From facts, authors concluded can represent potential candidates antiproliferative applicants. Moreover, hybrid 2i may serve valuable model creating potent anti-breast therapies.
Язык: Английский
Процитировано
6