Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease DOI Creative Commons
Ali Azargoonjahromi

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 18, 2024

Abstract Research on serotonin reveals a lack of consensus regarding its role in brain volume, especially concerning biomarkers linked to neurogenesis and neuroplasticity, such as ciliary neurotrophic factor (CNTF), fibroblast growth 4 (FGF-4), bone morphogenetic protein 6 (BMP-6), matrix metalloproteinase-1 (MMP-1) Alzheimer’s disease (AD). This study aimed investigate the influence structure hippocampal volumes relation cognitive functions AD, well link with like CNTF, FGF-4, BMP-6, MMP-1. Data from 133 ADNI participants AD included assessments (CDR-SB), measurements (Biocrates AbsoluteIDQ p180 kit, UPLC-MS/MS), factors quantified via multiplex proteomics. Gray matter volume changes were analyzed using Voxel-Based Morphometry (VBM) MRI. Statistical analyses employed Pearson correlation, bootstrap methods, FDR-adjusted p-values (< 0.05 or < 0.01) Benjamini–Hochberg procedure, alongside nonparametric methods. The analysis found positive correlation between levels total (r = 0.229, p 0.023) (right: r 0.186, 0.032; left: 0.210, 0.023), even after FDR adjustment. Higher better function (negative CDR-SB, −0.230, 0.024). Notably, positively correlated BMP-6 0.173, 0.047), CNTF 0.216, 0.013), FGF-4 0.176, 0.043), MMP-1 0.202, 0.019), suggesting neuroplasticity. However, adjusting for multiple comparisons controlling confounding age, gender, education, APOE genotypes (APOE3 APOE4), none correlations remained statistically significant. In conclusion, increased are associated improved volume. associations not significant adjustments, highlighting complexity serotonin’s need further research. Graphical

Language: Английский

A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum DOI
Xinyue Tang, Zixuan Guo, Guanmao Chen

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102240 - 102240

Published: Feb. 22, 2024

Language: Английский

Citations

20
Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases DOI
Mitra Pirhaghi, Fatemeh Mamashli, Faezeh Moosavi-Movahedi

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(5), P. 2097 - 2117

Published: March 5, 2024

Currently, one of the most significant and rapidly growing unmet medical challenges is treatment neurodegenerative diseases such as Alzheimer's disease (AD) Parkinson's (PD). This challenge encompasses imperative development efficacious therapeutic agents overcoming intricacies blood–brain barrier for successful drug delivery. Here we focus on delivery aspect with particular emphasis cell-penetrating peptides (CPPs), widely used in basic translational research they enhance to challenging targets tissue cellular compartments thus increase efficacy. The combination CPPs nanomaterials nanoparticles (NPs) improves performance, accuracy, stability enables higher loads. Our review presents discusses that utilizes CPPs, either alone or conjugation NPs, mitigate pathogenic effects reference AD PD.

Language: Английский

Citations

15
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons DOI
Monika Sharma, Pankaj Pal, Sukesh Kumar Gupta

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1829, P. 148797 - 148797

Published: Feb. 10, 2024

Language: Английский

Citations

14
Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue DOI Creative Commons
Olalekan Bukunmi Ogunro,

Mojisola Esther Karigidi,

Gideon Ampoma Gyebi

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 4, 2025

Language: Английский

Citations

1
Agmatine as a novel intervention for Alzheimer's disease: Pathological insights and cognitive benefits DOI

Raj Katariya,

Shivkumar S. Sammeta, Mayur B. Kale

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102269 - 102269

Published: March 11, 2024

Language: Английский

Citations

7
Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework DOI

Shuang-Jian Qin,

Qing-Guo Zeng,

Hui-Xian Zeng

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174450 - 174450

Published: July 3, 2024

Language: Английский

Citations

6
Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease DOI Creative Commons
María F. Colavitta, Francisco J. Barrantes

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2052 - 2052

Published: July 31, 2023

Alzheimer disease (AD) is the most prevalent form of dementia among elderly people. Owing to its varied and multicausal etiopathology, intervention strategies have been highly diverse. Despite ongoing advances in field, efficient therapies mitigate AD symptoms or delay their progression are still limited scope. Neuroplasticity, broad terms ability brain modify structure response external stimulation damage, has received growing attention as a possible therapeutic target, since disruption plastic mechanisms appear correlate with various forms cognitive impairment present patients. Several pre-clinical clinical studies attempted enhance neuroplasticity via different mechanisms, for example, regulating glucose lipid metabolism, targeting activity neurotransmitter systems, addressing neuroinflammation. In this review, we first describe several structural functional aspects neuroplasticity. We then focus on current status pharmacological approaches stemming from trials neuroplastic This followed by an analysis analogous interventions animal models, according action.

Language: Английский

Citations

13
Monoamine alterations in Alzheimer’s disease and their implications in comorbid neuropsychiatric symptoms DOI Creative Commons
Shalini Saggu,

Ava Bai,

Mae Aida

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

Citations

5
Innovative Design, Synthesis, and In Silico Evaluation of Bis-Ureido Substituted Antipyrine Derivatives: Molecular Modeling and ADME Insights DOI
Süleyman Akocak

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Journal Year: 2025, Volume and Issue: 15(1), P. 264 - 278

Published: Feb. 19, 2025

Molecular docking is a computational modeling technique that predicts the interactions between molecules of interest and certain protein structures. This approach estimates binding affinities visualizes bond interactions, making it useful tool for drug discovery. helps to rationally design new therapeutic medicines by offering insight into potential connections molecular structures prior laboratory testing. ADME investigations supplement assessing pharmacokinetic features examined compounds, consequently determining their eligibility as possible candidates. In this study, we show creative design, synthesis, silico evaluation novel series bis-ureido substituted antipyrine derivatives, with focus on cholinesterase inhibitors. Using tools, combined group improve pharmacological properties these molecules. The newly synthesized compounds were comprehensively characterized spectroscopic approaches, including FT-IR, ¹H-NMR, ¹³C-NMR, followed experiments analyze acetylcholinesterase (AChE) butyrylcholinesterase (BChE). Additionally, assessments performed determine compounds' characteristics drug-likeness properties. Notably, compound 10 showed strong against AChE BChE, energies -14.47 -11.75 kcal/mol, respectively. data revealed high affinities, indicating significant inhibitory both BChE. study points out need combining in contemporary pharmaceutical development.

Language: Английский

Citations

0
From Inhalation to Neurodegeneration: Air Pollution as a Modifiable Risk Factor for Alzheimer’s Disease DOI Open Access
Jordi Olloquequi, Roberto Díaz‐Peña, Ester Verdaguer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6928 - 6928

Published: June 25, 2024

Air pollution, a growing concern for public health, has been linked to various respiratory and cardiovascular diseases. Emerging evidence also suggests link between exposure air pollutants neurodegenerative diseases, particularly Alzheimer's disease (AD). This review explores the composition sources of pollutants, including particulate matter, gases, persistent organic heavy metals. The pathophysiology AD is briefly discussed, highlighting role beta-amyloid plaques, neurofibrillary tangles, genetic factors. article examines how reach brain exert their detrimental effects, delving into neurotoxicity pollutants. molecular mechanisms linking pollution neurodegeneration are explored in detail, focusing on oxidative stress, neuroinflammation, protein aggregation. Preclinical studies, vitro experiments animal models, provide direct effects neuronal cells, glial blood-brain barrier. Epidemiological studies have reported associations an increased risk cognitive decline. body supporting as modifiable factor underscores importance considering environmental factors etiology progression face worsening global quality.

Language: Английский

Citations

4