Lactoferrin-mediated targeting of oncogenic pathways for cancer chemoprevention and adjunct treatment: From mechanistic insights to clinical trials DOI Creative Commons

Iqra Mobeen,

Uteuliyev Yerzhan Sabitaliyevich,

Aizat Moldagassimova

et al.

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(4), P. 509 - 522

Published: Jan. 1, 2024

Genetic, genomic and proteomic analyses of cells, tissues body fluids have generated a wealth precious information about the intricate mechanisms which underlie carcinogenesis metastasis. Lactoferrin, multifunctional cationic glycoprotein, has attracted widespread appreciation because its characteristically novel properties for cancer chemoprevention. Tumor microenvironment is highly complicated sophisticated ecosystem, significantly reshaped by wide variety treatment regimes. Therefore, lactoferrin-mediated immunostimulatory role reshapes tumor inhibits progression. There sufficient experimental evidence related to ability lactoferrin in microenvironment. Different clinical trials been conducted evaluation efficacy different patients. It necessary carefully interpret identify major gaps our understanding selection group patients likely benefit most from combinatorial regime comprised chemotherapeutic drugs. Moreover, lack should be analyzed team interdisciplinary researchers broader comprehensive underlying failure.

Language: Английский

Nrf-2 as a novel target in radiation induced lung injury DOI Creative Commons
Yuanyuan Chen, Meng Wang,

Chenyang Zuo

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29492 - e29492

Published: April 1, 2024

Radiation-induced lung injury (RILI) is a common and fatal complication of chest radiotherapy. The underlying mechanisms include radiation-induced oxidative stress caused by damage to the deoxyribonucleic acid (DNA) production reactive oxygen species (ROS), resulting in apoptosis endothelial cells recruitment inflammatory myofibroblasts expressing NADPH oxidase site injury, which turn contribute cytokine production. Nuclear factor erythroid 2-related 2 (Nrf-2) vital transcription that regulates inhibits inflammation. Studies have shown Nrf-2 protects against inflammation fibrosis. This review discusses protective role RILI its possible mechanisms.

Language: Английский

Citations

4
Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment DOI Creative Commons
Qi Wan, Qing Ren,

Shuangying Qiao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 22, 2024

Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive poor prognosis, low survival within 5 years, as disease typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates PC intervention. Their mechanisms action include regulation autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, well enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, potentially boosting immunomodulatory responses. The demonstrated benefits natural compounds management spurred extensive academic interest. Beyond role anti-cancer agents, flavonoids may provide both preventive advantages PC, resonating core principles medicine prevention holistic

Language: Английский

Citations

3
Exosomes and exosomal miRNAs: A new avenue for the future treatment of rheumatoid arthritis DOI Creative Commons
Yuan Liu, Ping Jiang,

Yuan Qu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e28127 - e28127

Published: March 1, 2024

Rheumatoid arthritis is a chronic systemic autoimmune disease that involves mainly synovitis and joint injury one of the main causes disability. The pathogenesis rheumatoid complicated, treatment cycle long. traditional methods inhibiting inflammation immunosuppression are no longer sufficient for disease, so there an urgent need to seek new treatments. exocrine microenvironment kind microvesicle with lipid bilayer membrane structure can be secreted by most cells in body. This contains cell-specific proteins, lipids nucleic acids transmit this information from cell another. To achieve cell-to-cell communication. Exocrine microRNAs contained selectively transferred target receptor via signaling, thus regulating physiological function cells. article focuses on pathological changes occur during development biological regulation joints. Research roles inflammatory response, proliferation/apoptosis, autophagy, effects fibroblast-like synoviocytes immune was reviewed. In addition, challenges faced discussed.

Language: Английский

Citations

1
Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy DOI Creative Commons
Rükset Attar, Muhammad Zahid Qureshi, Uteuliyev Yerzhan Sabitaliyevich

et al.

Cellular and Molecular Biology, Journal Year: 2024, Volume and Issue: 70(4), P. 260 - 267

Published: April 28, 2024

Language: Английский

Citations

0
Lactoferrin-mediated targeting of oncogenic pathways for cancer chemoprevention and adjunct treatment: From mechanistic insights to clinical trials DOI Creative Commons

Iqra Mobeen,

Uteuliyev Yerzhan Sabitaliyevich,

Aizat Moldagassimova

et al.

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(4), P. 509 - 522

Published: Jan. 1, 2024

Genetic, genomic and proteomic analyses of cells, tissues body fluids have generated a wealth precious information about the intricate mechanisms which underlie carcinogenesis metastasis. Lactoferrin, multifunctional cationic glycoprotein, has attracted widespread appreciation because its characteristically novel properties for cancer chemoprevention. Tumor microenvironment is highly complicated sophisticated ecosystem, significantly reshaped by wide variety treatment regimes. Therefore, lactoferrin-mediated immunostimulatory role reshapes tumor inhibits progression. There sufficient experimental evidence related to ability lactoferrin in microenvironment. Different clinical trials been conducted evaluation efficacy different patients. It necessary carefully interpret identify major gaps our understanding selection group patients likely benefit most from combinatorial regime comprised chemotherapeutic drugs. Moreover, lack should be analyzed team interdisciplinary researchers broader comprehensive underlying failure.

Language: Английский

Citations

0