Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 11, 2025
Polygonatum
is
a
traditional
medicinal
and
edible
plant
often
prepared
by
steaming
it
with
ingredients
like
yellow
rice
wine
black
beans.
However,
the
metabolic
changes
in
kingianum
(PK)
during
method
beans
have
not
been
previously
reported.
This
study
aims
to
explore
how
addition
of
degree
affect
quality
PK.
quantified
polysaccharides,
reducing
sugars,
saponins,
flavonoids
PK
subjected
varied
cycles,
while
also
integrating
color
measurement,
sensory
evaluation,
non-targeted
metabolomics
analysis.
rich
lipids,
amino
acids,
flavonoids,
organic
acids.
Notably,
we
observed
production
significant
accumulation
daidzein
daidzin
(two
primary
active
compounds
derived
from
beans)
as
well
triterpenoid
saponins
(including
Sandosaponin
A,
Soyasaponin
II-III,
V,
Pisumsaponin
I-II)
steamed
(p
<
0.05).
After
three
multiple
bioactive
levels
peaked
or
stabilized,
which
was
consistent
(score:
94/100).
Compared
raw
PK,
P3
stage
exhibited
increases
total
21.29,
35.02,
49.13,
44.76%,
respectively
0.05),
sugars
showed
remarkable
increase
160.94-fold
0.01),
polysaccharides
decreased
significantly
43.33%
0.01).
provides
first
evidence
that
can
synergistically
diversity
isoflavones
optimal
achieved
after
rounds
steaming.
These
findings
validate
scientific
efficacy
processing
method.
Our
results
advocate
for
continued
use
bean
enhance
nutritional
health-promoting
value
providing
template
innovation
herbal
techniques
based
on
auxiliary
ingredients.
Future Foods,
Год журнала:
2024,
Номер
9, С. 100313 - 100313
Опубликована: Фев. 9, 2024
Natural
substances
present
in
plants
called
phytochemicals
are
essential
for
fostering
favourable
human
health
outcomes.
These
bioactive
compounds
support
general
via
a
variety
of
processes.
Phytochemicals
have
strong
antioxidant
qualities
that
aid
scavenging
dangerous
free
radicals
from
the
body.
This
activity
can
promote
cellular
by
lowering
oxidative
stress,
major
contributor
to
ageing
and
onset
chronic
diseases.
exhibit
dosage-dependent
effect,
which
either
beneficial
or
detrimental
outcome.
Several
vivo
vitro
studies
been
conducted
strongly
supports
health-promoting
properties
diets.
A
diet
is
rich
derived
fruits,
vegetables,
nuts,
legumes,
whole
grains
has
linked
lower
incidence
lipid
peroxidation,
cardiovascular
disorders,
cancer,
other
illnesses.
Compounds
such
as
β-glucans
echinacea
stimulate
immune
responses,
enhancing
body's
ability
defend
against
infections
The
study
expanded
understanding
biochemical
diversity
their
potential
applications
various
fields
life,
including
food
nutrition,
pharmaceuticals,
cosmetics,
agriculture.
review
deals
with
significance
varieties
used
enhance
nutrition
overall
health.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(4), С. 2007 - 2022
Опубликована: Фев. 19, 2024
Abstract
This
review
highlights
the
increasing
interest
in
one
of
natural
compounds
called
saponins,
for
their
potential
therapeutic
applications
addressing
inflammation
which
is
a
key
factor
various
chronic
diseases.
It
delves
into
molecular
mechanisms
responsible
anti‐inflammatory
effects
these
amphiphilic
compounds,
prevalent
plant‐based
foods
and
marine
organisms.
Their
structures
vary
with
soap‐like
properties
influencing
historical
uses
traditional
medicine
sparking
renewed
scientific
interest.
Recent
research
focuses
on
inflammatory
diseases,
unveiling
actions
such
as
NF‐κB
MAPK
pathway
regulation
COX/LOX
enzyme
inhibition.
Saponin‐containing
sources
like
Panax
ginseng
soybeans
suggest
novel
therapies.
The
explores
emerging
role
shaping
gut
microbiome,
composition
activity,
contributing
to
effects.
Specific
examples,
notoginseng
Gynostemma
pentaphyllum
,
illustrate
intricate
relationship
between
collective
impact
immune
metabolic
health.
Despite
promising
findings,
emphasizes
need
further
comprehend
behind
interactions
underscoring
crucial
balanced
microbiome
optimal
health
positioning
saponins
dietary
interventions
managing
conditions.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 7, 2024
Recent
research
on
traditional
Chinese
medicine
(TCM)
saponin
pharmacokinetics
has
revealed
transformative
breakthroughs
and
challenges.
The
multicomponent
nature
of
TCM
makes
it
difficult
to
select
representative
indicators
for
pharmacokinetic
studies.
clinical
application
saponins
is
limited
by
their
low
bioavailability
short
half-life,
resulting
in
fluctuating
plasma
concentrations.
Future
directions
should
focus
novel
compounds
utilizing
colon-specific
delivery
osmotic
pump
systems
enhance
oral
bioavailability.
Optimizing
drug
combinations,
such
as
ginsenosides
with
aspirin,
shows
therapeutic
potential.
Rigorous
validation
essential
practical
applications.
This
review
emphasizes
a
era
research,
highlighting
the
need
validation.
pharmacokinetics,
guided
principles,
are
development,
multidisciplinary
approaches
comprehensive
understanding.
provides
theoretical
basis
new
drugs
supports
rational
medication.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(4)
Опубликована: Фев. 15, 2024
Yerba
mate
(Ilex
paraguariensis)
is
a
forest
species
consumed
in
the
form
of
non-alcoholic
beverages
South
America,
with
applications
foods,
cosmetics,
and
pharmaceutical
industries.
The
leaves
are
globally
recognized
for
their
important
bioactive
compounds,
including,
saponins.
We
adjusted
vanillin-acid
sulfuric
method
determining
spectrophotometrically
total
saponin
yerba
leaves.
Seeking
to
maximize
extraction
saponins
from
leaves,
Doehlert
design
combined
Response
Surface
Methodology
(RSM)
was
used,
considering
ethanol:water
ratios
ultrasound
times.
In
addition,
same
methodology
used
analysis
times
temperatures
vanillin-sulfuric
acid
reaction
heating.
contents
mature
were
compared
four
clones.
maximized
using
40
%
ethanol:60
water
60
minutes
assisted
(UAE)
without
For
conditions,
70
°C
10
heating
recommended,
UV/Vis
reading
460
680
nm.
Using
optimized
methodology,
ranged
28.43
53.09
mg
g
Foods,
Год журнала:
2024,
Номер
13(15), С. 2408 - 2408
Опубликована: Июль 29, 2024
Antinutrients,
also
known
as
anti-nutritional
factors
(ANFs),
are
compounds
found
in
many
plant-based
foods
that
can
limit
the
bioavailability
of
nutrients
or
act
precursors
to
toxic
substances.
ANFs
have
controversial
effects
on
human
health,
depending
mainly
their
concentration.
While
positive
these
well
documented,
dangers
they
pose
and
approaches
avoid
them
not
been
discussed
same
extent.
There
is
no
dispute
negatively
alter
absorption
vitamins,
minerals,
proteins
addition
inhibiting
some
enzyme
activities,
thus
affecting
body.
This
review
discusses
chemical
properties,
plant
bioavailability,
deleterious
anti-minerals
(phytates
oxalates),
glycosides
(cyanogenic
saponins),
polyphenols
(tannins),
proteinaceous
(enzyme
inhibitors
lectins).
The
focus
this
study
possibility
controlling
amount
ANF
food
through
fermentation.
An
overview
most
common
biochemical
pathways
for
microbial
reduction
provided,
showing
genetic
basis
phenomena,
including
active
enzymes,
optimal
conditions
action,
data
regulation
synthesis.
Scientific African,
Год журнала:
2024,
Номер
24, С. e02212 - e02212
Опубликована: Апрель 6, 2024
The
curative
effects
of
Solanum
elaeagnifolium
have
aroused
the
interest
botanical
medicine
researchers.
However,
no
research
has
been
carried
out
into
its
potential
toxicity.
aim
this
study
was
firstly
to
screen
secondary
metabolites
contained
in
leaves
and
fruits
S.
their
mineralogical
composition,
secondly
assess
acute
oral
toxicity
Swiss
albino
mice.
amount
minerals
plant
powder
assessed
by
inductively
coupled
plasma
atomic
emission
spectrometry,
phytochemical
screening
performed.
hydroethanolic
extracts
were
prepared
using
maceration
method.
Acute
according
OECD
guideline
423.
Mice
given
leaf
(SEFE)
fruit
(SEFR)
once
at
doses
500
mg/kg,
1000
mg/kg
2000
an
study.
animals
then
monitored
for
14
days.
To
rule
any
toxicity,
general
behavior
animals,
clinical
symptoms
poisoning,
body
weight,
biochemical
hematological
markers,
liver,
kidney,
spleen
histology
examined.
two
different
comprised
very
important
elements
such
as
Mg,
Zn,
k,
well
polyphenols
flavonoids,
these
chemical
shown
biological
activities.
An
administration
a
extract
dose
resulted
death
We
found
significant
difference
weight
For
less
than
markers
kidneys,
hematology
did
not
differ
significantly
from
those
control
group.
Furthermore,
there
changes
markers.
architecture
spleen,
kidney
normal
histopathological
analysis
reveal
adverse
effects.
These
findings
indicate
that
harbors
array
minerals.
exhibited
signs
induced
histological,
hematological,
alterations
weight.
comprehensive
studies
will
help
improve
our
understanding
elaeagnifolium's
safety
utility,
laying
groundwork
safe
use
variety
settings.
