Cellular Signalling, Год журнала: 2023, Номер 106, С. 110650 - 110650
Опубликована: Март 17, 2023
Язык: Английский
Frontiers in Immunology, Год журнала: 2021, Номер 12
Опубликована: Ноя. 3, 2021
Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged behind these drugs cancers, due in part from concerns over the lack selectivity and associated toxicity profiles first generation drug candidates when used long term treatment immune mediated diseases. Second have made great strides limiting off-target activities distantly related kinases, though they had variable success at cross-reactivity within more closely TEC family kinases. We investigated specificity profiles, properties, disease signaling pathways, clinical indications, trial successes failures 13 inhibitor tested phase 2 or higher trials representing 7 inflammatory immune-mediated focused on rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) where majority nonclinical studies been reported, with additional information pemphigus vulgaris (PV), Sjogren’s (SJ), chronic spontaneous urticaria (CSU), graft versus host (GVHD), asthma included available. While improved kinases outside less profile distinction was evident family. Analysis genetic associations RA, MS, SLE biomarkers members revealed that may not be drivers disease. They are, however, mediators pathways pathophysiology particular B cell myeloid differentiation as well autoantibody implicated Successes clinic PV, ITP, GVHD, but SJ support concept plays an important role mediating pathogenic processes amenable to therapeutic intervention, depending Based data collected this study, we propose current compound characteristics achieved selectivity, safety, coverage requirements necessary deliver benefit.
Язык: Английский
Процитировано
93
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(2), С. 658 - 658
Опубликована: Янв. 11, 2021
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of exocrine glands including salivary and lachrymal responsible for classical dry eyes mouth symptoms (sicca syndrome). The spectrum manifestations stretches beyond sicca with systemic arthritis, interstitial lung involvement, neurological involvement. pathophysiology underlying SS not well deciphered, but several converging lines evidence have supported conjuncture different factors interplaying together to foster initiation perpetuation disease. innate adaptive immune system play cardinal role in this process. In review, we discuss inherent parts played both pathogenesis SS.
Язык: Английский
Процитировано
58
World Journal of Gastroenterology, Год журнала: 2022, Номер 28(23), С. 2527 - 2545
Опубликована: Июнь 16, 2022
Systemic rheumatic diseases (SRDs) are chronic, inflammatory, autoimmune disorders with the presence of autoantibodies that may affect any organ or system. Liver dysfunction in SRDs can be associated prescribed drugs, viral hepatitis, alternative hepatic comorbidities and coexisting liver (AILDs), requiring an exclusion secondary conditions before considering involvement. The patterns overlap depend predominantly on genetic determinants common susceptible loci widely distributing both disorders. In AILDs, it is important to identify overlapping at early stage since such a coexistence influence disease course prognosis. Commonly co-occurring AILDs Sjögren syndrome (SS), rheumatoid arthritis (RA) systemic lupus erythematosus (SLE) hepatitis (AIH), SS, RA sclerosis primary biliary cholangitis. Owing different complications therapies, imperative differentiate between SLE involvement SLE-AIH disease. Therapeutic options personalized control autoimmunity manifestations AILD-SRD diseases. collaboration hepatologists rheumatologists lead significant advances managing complex scenario. this review, we provide comprehensive overview therapeutic approach these
Язык: Английский
Процитировано
40
Autoimmunity Reviews, Год журнала: 2023, Номер 22(3), С. 103268 - 103268
Опубликована: Янв. 5, 2023
Язык: Английский
Процитировано
25
Arthritis Research & Therapy, Год журнала: 2024, Номер 26(1)
Опубликована: Фев. 8, 2024
Abstract Sjögren’s disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and need to identified managed in timely manner. Treatment should tailored the type severity of organ involvement, ideally based on multidisciplinary evaluation.
Язык: Английский
Процитировано
10
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Sjögren's syndrome‐related dry eye (SSDE) is a severe subtype characterized by significant immune cell attacks on the lacrimal gland. However, delivering immunosuppressive drugs to glands for SSDE therapy safely and sustainably poses challenges in clinical practice. Herein, ROS‐responsive microneedle patch with detachable functionality (CE‐MN) developed enable straightforward minimally invasive administration gland area penetrating periocular skin. CE‐MN loaded cyclosporin A anti‐inflammatory drug epigallocatechin gallate, latter also serving as cross‐linker matrix. Poly(N‐isopropylacrylamide‐co‐butylacrylate), temperature‐sensitive polymer utilized fabricate separable layers that allow controlled detachment of base from needle, reducing patient discomfort. capable modulating release responding ROS, facilitating on‐demand release, accumulation Compared traditional drops, facilitated long‐acting delivery more than 48 h, demonstrating potent effects an mouse model scavenging ROS inhibiting proliferation Th1, Th17 cells, macrophages. Overall, this potentially offers novel approach treating other ocular chronic diseases.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 11179 - 11179
Опубликована: Июль 6, 2023
Sjögren's syndrome (SS) is an autoimmune disease characterized by the involvement of exocrine glands such as salivary and lacrimal glands. The minor glands, from which tissue samples may be obtained, are important for diagnosis, evaluation therapeutic efficacy, genetic analyses SS. In onset SS, autoantigens derived recognized antigen-presenting dendritic cells, leading to activation T B cytokine production, autoantibody production plasma formation ectopic germinal centers, destruction gland epithelial cells. A recent approach with immune checkpoint inhibitors malignant tumors enhances anti-tumor activity cytotoxic effector but also induces SS-like adverse event. treatment xerostomia, muscarinic agonists duct cleansing procedure, well sialendoscopy, expected ameliorate symptoms. Clinical trials on biological therapy attenuate hyperresponsiveness cells in SS patients systemic organ have progressed. efficacy mesenchymal stem chimeric antigen receptor has been investigated. this review, we will provide overview pathogenesis lesions trends approaches
Язык: Английский
Процитировано
16
Viruses, Год журнала: 2024, Номер 16(1), С. 133 - 133
Опубликована: Янв. 17, 2024
Alzheimer’s disease and Parkinson’s represent the most common forms of cognitive impairment. Multiple sclerosis is a chronic inflammatory central nervous system responsible for severe disability. An aberrant immune response cause myelin destruction that covers axons in brain, spinal cord, optic nerves. Systemic lupus erythematosus an autoimmune characterized by alteration B cell activation, while Sjögren’s syndrome heterogeneous altered responses. The etiology all these diseases very complex, including interrelationship between genetic factors, principally associated genes, environmental factors such as infectious agents. However, neurodegenerative share proinflammatory signatures perturbation adaptive immunity might be influenced herpesviruses. Therefore, they play critical role pathogenesis. aim this review was to summarize principal findings link herpesviruses both diseases; moreover, briefly underlining potential therapeutic approach virus vaccination antivirals.
Язык: Английский
Процитировано
6
Rheumatology and Therapy, Год журнала: 2021, Номер 8(3), С. 1051 - 1059
Опубликована: Июль 5, 2021
Sjögren's syndrome (SS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This leads to dryness main mucosal surfaces such as mouth, eyes, nose, larynx, pharynx, and vagina. Although there little morbidity data at initial diagnosis, SS may be serious with extra mortality caused hematological cancer. The cause unknown, but factors postulated play role include genetic environmental factors, hormonal abnormality, viral infection. Under influence these immune system becomes abnormal tissue damaged. In this study, we summarize recent developments in our understanding relationship between infections, including Epstein–Barr virus (EBV), hepatitis C (HCV), human T cell lymphotropic type 1 (HTLV-1), cytomegalovirus (CMV), immunodeficiency (HIV).
Язык: Английский
Процитировано
34
Journal of Biomedical Science, Год журнала: 2022, Номер 29(1)
Опубликована: Июнь 6, 2022
Abstract Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer Sjögren’s syndrome. Multiple SG engineering strategies have been considered regeneration, repair, or whole organ replacement. An in-depth understanding development differentiation epithelial stem progenitor cells niche during branching morphogenesis signaling pathways involved in cell–cell communication constitute a prerequisite to suitable bioengineering solutions. This review summarizes essential features be fabricate an engineered functional model using various cell types, biomaterials, active agents, matrix fabrication methods. Furthermore, recent innovative promising approaches models are described. Finally, this discusses different challenges future perspectives bioengineering.
Язык: Английский
Процитировано
26