An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

Molecules, Год журнала: 2017, Номер 22(7), С. 1037 - 1037

Опубликована: Июнь 23, 2017

Marine secondary metabolites are a promising source of unexploited drugs that have wide structural diversity and shown variety biological activities. These compounds produced in response to the harsh competitive conditions occur marine environment. Invertebrates considered be among groups with richest biodiversity. To date, significant number natural products (MNPs) been established as antineoplastic drugs. This review gives an overview MNPs, both research or clinical stages, from diverse organisms were reported being active potentially cancer treatment past seventeen years (from January 2000 until April 2017) describes their putative mechanisms action. The MNPs is also highlighted compared small-molecule anticancer use. In addition, this examines use virtual screening for MNP-based drug discovery reveals classical approaches selection candidates based on ADMET (absorption, distribution, metabolism, excretion, toxicity) filtering may miss potential lead compounds. Finally, we introduce novel publically accessible chemical library purposes.

Язык: Английский

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Marine microorganisms as a promising and sustainable source of bioactive molecules

Marine Environmental Research, Год журнала: 2016, Номер 128, С. 58 - 69

Опубликована: Май 3, 2016

Язык: Английский

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The Essentials of Marine Biotechnology

Frontiers in Marine Science, Год журнала: 2021, Номер 8

Опубликована: Март 16, 2021

Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well tried to support new economic endeavors (ocean energy, desalination for water supply, seabed mining). Modern societies lifestyle resulted in an increased demand dietary diversity, better health well-being, biomedicines, natural cosmeceuticals, environmental conservation, sustainable energy sources. These societal needs stimulated interest of researchers diverse underexplored environments promising sources biomolecules biomass, they are addressed by emerging field (blue) biotechnology. Blue biotechnology provides opportunities a wide range initiatives commercial pharmaceutical, biomedical, cosmetic, nutraceutical, feed, agricultural, related industries. This article synthesizes essence, opportunities, responsibilities, challenges encountered outlines attainment valorization directly derived or bio-inspired products from organisms. First, concept bioeconomy is introduced. Then, diversity bioresources including overview most prominent organisms their potential biotechnological uses described. followed introducing methodologies exploration these main use case scenarios food agronomy, bioremediation climate change, materials, healthcare, well-being sectors. The key aspects fields legislation funding provided, with emphasis importance communication stakeholder engagement at all levels development. Finally, vital overarching concepts, such quadruple helix Responsible Research Innovation principle highlighted important follow within field. authors this review collaborating under European Commission-funded Cooperation Science Technology (COST) Action Ocean4Biotech – transdisciplinary networking platform focus study state affairs.

Язык: Английский

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Marine Sponge Natural Products with Anticancer Potential: An Updated Review

Marine Drugs, Год журнала: 2017, Номер 15(10), С. 310 - 310

Опубликована: Окт. 13, 2017

Despite the huge investment into research and significant effort advances made in search for new anticancer drugs recent decades, cancer cure treatment continue to be a formidable challenge. Many sources, including plants, animals, minerals, have been explored oncological field because of possibility identifying novel molecular therapeutics. Marine sponges are prolific source secondary metabolites, number which showed intriguing tumor chemopreventive chemotherapeutic properties. Recently, Food Drug Administration-approved derived from marine shown reduce metastatic breast cancer, malignant lymphoma, Hodgkin's disease. The potential activity sponge-derived compounds could explained by multiple cellular mechanisms, DNA protection, cell-cycle modulation, apoptosis, anti-inflammatory activities as well their ability chemosensitize cells traditional antiblastic chemotherapy. present article aims depict mechanisms involved therapeutic effects critically explore limitations challenges associated with development sponge-based strategy.

Язык: Английский

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Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics

Molecules, Год журнала: 2020, Номер 25(11), С. 2536 - 2536

Опубликована: Май 29, 2020

The cosmetic industry is among the fastest growing industries in last decade. As beauty concepts have been revolutionized, many terms coined to accompany innovation of this industry, since products are not just confined those that applied protect and enhance appearance human body. Consequently, such as cosmeceuticals nutricosmetics emerged give a notion health benefits create from inside outside. In past years, natural products-based gained huge amount attention only researchers but also public due general belief they harmless. Notably, recent demand for marine resources has exponentially on rise their unique chemical biological properties found terrestrial resources. Therefore, present review addresses importance marine-derived compounds, stressing new entities with cosmeceutical potential mechanisms action by which these compounds exert body functions well related benefits. Marine environments most important reservoir biodiversity provide biologically active substances whose still be discovered application pharmaceuticals, nutraceuticals, cosmeceuticals. organisms an renewable source valuable bulk used agar carrageenan, gelling thickening agents increase viscosity formulations, small molecules ectoine (to promote skin hydration), trichodin A prevent product alteration caused microbial contamination), mytiloxanthin (as coloring agent). Marine-derived can function ingredients, being main determine anti-tyrosinase (kojic acid), antiacne (sargafuran), whitening (chrysophanol), UV protection (scytonemin, mycosporine-like amino acids (MAAs)), antioxidants, anti-wrinkle (astaxanthin PUFAs).

Язык: Английский

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Mainstreaming marine biodiversity into the SDGs: The role of other effective area-based conservation measures (SDG 14.5)

Marine Policy, Год журнала: 2017, Номер 93, С. 251 - 261

Опубликована: Сен. 5, 2017

This article explores the concept of "other effective area-based conservation measures" (OECMs) in context UN Convention on Biological Diversity (CBD) Aichi Biodiversity Target 11 marine protected areas and OECMs its linkages to Sustainable Development Goals (SDGs). It argues that mainstreaming biodiversity through CBD Targets' implementation into SDGs can contribute a more systemic comprehensive SDG 14.5 at least 10% coastal areas. complement MPAs ecologically representative effectively managed systems integrated broader governance such as spatial planning. Selected global local sectoral measures are therefore highlighted this analysis potential forms OECMs. At level, case study or biologically significant locally (LMMAs) Mozambique is discussed. how multiple-use LMMAs, which respond short-term fisher's needs targeted conservation, could achievement specific food security, poverty elimination resilient ecosystems if properly supported by long-term investments, strong institutions oceans management.

Язык: Английский

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Marine Organisms with Anti-Diabetes Properties

Marine Drugs, Год журнала: 2016, Номер 14(12), С. 220 - 220

Опубликована: Дек. 1, 2016

Diabetes is a chronic degenerative metabolic disease with high morbidity and mortality rates caused by its complications. In recent years, there has been growing interest in looking for new bioactive compounds to treat this disease, including metabolites of marine origin. Several aquatic organisms have screened evaluate their possible anti-diabetes activities, such as bacteria, microalgae, macroalgae, seagrasses, sponges, corals, sea anemones, fish, salmon skin, shark fusion protein well fish shellfish wastes. Both vitro vivo screenings used test anti-hyperglycemic anti-diabetic activities organisms. This review summarizes discoveries properties several wastes, existing patents future research directions field.

Язык: Английский

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Marine bacteria as source of antimicrobial compounds

Critical Reviews in Biotechnology, Год журнала: 2020, Номер 40(3), С. 306 - 319

Опубликована: Янв. 28, 2020

The marine environment encompasses a huge biological diversity and can be considered as an underexplored location for prospecting bioactive molecules. In this review, the current state of art about antimicrobial molecules from bacteria has been summarized considering main phylum sources evolved in environment. Considering last two decades, we have found most studied group producers substances with activity is Firmicutes phylum, particular strains Bacillus genus. reason that attributed to difficult cultivation typical Actinobacteria sediment, whose members are major land environments. However, reversed trend observed recent years increasing number reports settling on Actinobacteria. Great chemical structures identified, such fijimicyns lynamicyns Actinomycetes macrolactins produced by Bacillus.

Язык: Английский

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An Overview on Marine Sponge-Symbiotic Bacteria as Unexhausted Sources for Natural Product Discovery

Diversity, Год журнала: 2017, Номер 9(4), С. 40 - 40

Опубликована: Сен. 21, 2017

Microbial symbiotic communities of marine macro-organisms carry functional metabolic profiles different to the ones found terrestrially and within surrounding environments. These bacteria have increasingly been a focus microbiologists working in environments due wide array reported bioactive compounds therapeutic importance resulting various patent registrations. Revelations symbiont-directed host specific functions true nature host-symbiont interactions, combined with metagenomic advances detecting gene clusters, will inevitably open new avenues for identification discovery novel biotechnological value from resources. This review article provides an overview on organisms emphasis placed sponge-associated invites international scientific community contribute towards establishment in-depth information environmental parameters defining selection acquisition symbionts by organisms.

Язык: Английский

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Collagen from the Marine Sponges Axinella cannabina and Suberites carnosus: Isolation and Morphological, Biochemical, and Biophysical Characterization

Marine Drugs, Год журнала: 2017, Номер 15(6), С. 152 - 152

Опубликована: Май 29, 2017

In search of alternative and safer sources collagen for biomedical applications, the marine demosponges Axinella cannabina Suberites carnosus, collected from Aegean Ionian Seas, respectively, were comparatively studied their insoluble collagen, intercellular spongin-like content. The isolated collagenous materials morphologically, physicochemically, biophysically characterized. Using scanning electron microscopy transmission fibrous morphology collagens was confirmed, whereas amino acid analysis, in conjunction with infrared spectroscopy studies, verified characteristic profile its secondary structure. Furthermore, isoelectric point thermal behavior determined by titration differential calorimetry, combination circular dichroism spectroscopic respectively.

Язык: Английский

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