International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140902 - 140902
Опубликована: Фев. 1, 2025
Язык: Английский
Bioactive Materials, Год журнала: 2024, Номер 38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.
Язык: Английский
Процитировано
28
Discover Materials, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 9, 2025
Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.
Язык: Английский
Процитировано
12
Journal of Composites Science, Год журнала: 2025, Номер 9(3), С. 133 - 133
Опубликована: Март 13, 2025
Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 764 - 764
Опубликована: Янв. 17, 2025
Marine polysaccharide hydrogels have emerged as an innovative platform for regulating the in vivo release of natural bioactive compounds medical purposes. These hydrogels, which exceptional biocompatibility, biodegradability, and high water absorption capacity, create effective matrices encapsulating different molecules. In addition, by modifying physical chemical properties marine including cross-linking density, swelling behavior, response to external stimuli like pH, temperature, or ionic strength, profile encapsulated is strictly regulated, thus maximizing therapeutic efficacy minimizing side effects. Finally, using naturally sourced polysaccharides hydrogel formulations, sustainability promoted reducing dependence on synthetic polymers, meeting growing demand eco-friendly materials. This review analyzes interaction between offers examples how molecules can be encapsulated, released, stabilized.
Язык: Английский
Процитировано
3
Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 15
Опубликована: Янв. 27, 2025
Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity excellent biocompatibility create an ideal moist environment for healing, thereby enhancing cell proliferation tissue regeneration. For this reason, naturally derived formulated from biomaterials such as chitosan, alginate, gelatin, fibroin are highly promising biodegradability low immunogenic responses. Recent integrated approaches utilizing new technologies with bioactive agents significantly improved the mechanical properties of controlled release delivery active compounds, efficiency treatment processes. Herein, review highlights advantages challenges focusing on strength, degradation rates, safety validation, potential incorporating advanced engineering gene therapy utilization personalized medicine.
Язык: Английский
Процитировано
3
Environmental Research, Год журнала: 2023, Номер 243, С. 117889 - 117889
Опубликована: Дек. 10, 2023
In the last decade, both cellulose and alginate polysaccharides have been extensively utilized for synthesis of biocompatible hydrogels because their alluring characteristics like low cost, biodegradability, hydrophilicity, ease availability non-toxicity. The presence abundant hydrophilic functional groups (like carboxyl hydroxyl) on surface or derivatives makes these materials promising candidates preparation with appealing structures characteristics, leading to growing research in water treatment biomedical fields. These two are typically blended together improve hydrogels' desired qualities (mechanical strength, adsorption properties, cellulose/alginate yield). So, keeping view extensive applicability, present review article, recent advances development cellulose/nanocellulose-alginate-based relevance (adsorption dyes, heavy metals, etc.) field (wound healing, tissue engineering, drug delivery) has reviewed. Further, impact other inorganic/organic additives properties contaminants adsorption, delivery, etc., also studied. Moreover, current difficulties future prospects nanocellulose-alginate-based regarding purification applications discussed at end.
Язык: Английский
Процитировано
31
Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(10), С. 497 - 497
Опубликована: Окт. 8, 2023
Within the human body, intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen maintaining homeostasis. Bioprinting is an innovative technology with potential to revolutionize this field by constructing complex multicellular structures. This technique offers advantage depositing individual cells, growth factors, biochemical signals, thereby facilitating functional vessels. Despite challenges fabricating vascularized constructs, bioprinting has emerged as advance organ engineering. The continuous evolution biomaterial knowledge provides avenue overcome hurdles associated tissue fabrication. article overview biofabrication process used create vascular constructs. It delves into various techniques engineering, including extrusion-, droplet-, laser-based methods. Integrating these prospect crafting artificial remarkable precision functionality. Therefore, impact engineering significant. With technological advances, it holds promise revolutionizing transplantation, regenerative medicine. By mimicking natural complexity vessels, brings us one step closer organs vasculature, ushering new era medical advancement.
Язык: Английский
Процитировано
27
Infection and Drug Resistance, Год журнала: 2024, Номер Volume 17, С. 791 - 805
Опубликована: Март 1, 2024
Abstract: Untreated topical infections can become chronic, posing serious health issues. Optimal skin adherence is crucial in addressing such infections. In this context, chitosan and alginate emerge as promising candidates for use a foundation the development of hydrogels. The aim review to examine literature on hydrogel formulations that foundations, specifically context antibacterial agents. research methodology involves by examining articles published databases PubMed, Scopus, ScienceDirect, Google Scholar. keywords employed during were "Alginate", "Chitosan", "Hydrogel", "Antibacterial". Chitosan serve bases hydrogels deliver various active ingredients, particularly agents, indicated search results. Both have demonstrated significant effectiveness, evidenced reduction bacterial colony counts an increase inhibition zones. This strongly supports idea could be used together make kill bacteria work well. conclusion, alginate-based show great potential treating surface. incorporation into aids retaining allowing their gradual release over optimal period. Therefore, formulated with solution address challenges treatment Keywords: Alginate, chitosan, hydrogel, topical, agent
Язык: Английский
Процитировано
15
Опубликована: Фев. 27, 2024
The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to production is crucial. This review focuses on seaweed as a sustainable resource for greening processes. Seaweed offers advantages such renewability, abundance, and positive footprint. begins by providing an overview practices the challenges faced achieving sustainability. It then discusses resource, including cultivation techniques benefits. has various applications manufacturing, extracting purifying bioactive compounds with potential therapeutic properties. Seaweed’s role developing green technologies, seaweed-based excipients, biodegradable packaging materials, source energy processes, highlighted. economic implications incorporating solutions are discussed, emphasizing reduced carbon footprint cost-effectiveness. Regulatory industrial perspectives addressed, examining challenges, opportunities implementing manufacturing. Collaboration between academia, industry, regulatory bodies crucial successful integration. presents future directions opportunities, emerging trends innovations areas further research, policy development, industry engagement recommendations. Incorporating into facilitates reduction impact, promotes efficiency, contributes showcases means foster greener addressing concerns, promoting
Язык: Английский
Процитировано
14
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135152 - 135152
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
10