Polymers,
Journal Year:
2025,
Volume and Issue:
17(4), P. 506 - 506
Published: Feb. 15, 2025
The
prevalence
of
bacterial
infections
in
wounds
is
a
significant
challenge
to
successful
wound
healing.
This
study
investigates
the
antibacterial
effect
hyaluronic
acid
and
alginate
aerogel
loaded
with
zinc
oxide
nanoparticles
as
potential
dressing
for
composite
was
synthesized
via
supercritical
gel
drying
characterized
by
scanning
electron
microscope,
Fourier
transform
infrared
spectroscopy,
nitrogen
porosimetry.
absorptivity
prepared
evaluated,
well
activity,
which
evaluated
against
common
pathogens,
including
Staphylococcus
aureus
Escherichia
coli,
using
agar
diffusion
method.
results
show
effective
properties
hydrogel
aerogel.
Furthermore,
water
absorption
ability
5791
1585%
unloaded
aerogels,
respectively.
ZnO
released
from
exhibited
rapid
release
followed
slow
sustained
release.
These
findings
highlight
aerogels
based
on
an
innovative
material,
expected
improve
healing
reduce
risk
infections.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Discover Materials,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 9, 2025
Achieving
the
ideal
replacement
for
robust
biological
tissues
requires
biocompatible
materials
with
a
nuanced
blend
of
characteristics,
including
organ
specific
toughness,
durability,
self-repairing
capability,
and
well-defined
structure.
Hydrogels,
structured
high
water
containing
3D-crosslinked
polymeric
networks,
present
promising
avenue
in
biomedical
applications
due
to
their
close
resemblance
natural
tissues.
However,
mechanical
performance
often
falls
short,
limiting
clinical
applications.
Recent
research
has
been
focused
on
developing
hydrogel
therapeutic
advancements
have
spurred
researchers
develop
hydrogels
having
acceptable
toughness.
While
it
is
now
possible
tailor
properties
synthetic
gels
mimic
those
tissues,
critical
aspects
such
as
biocompatibility
crosslinking
strategies
are
frequently
neglected.
This
review
scrutinizes
structural
techniques
designed
improve
toughness
hydrogels,
focusing
especially
innovative
efforts
integrate
these
enhancements
into
natural-based
hydrogels.
By
thoroughly
examining
methodologies,
sheds
light
complexities
strengthening
will
propose
valuable
insights
development
next-generation
tissue
substitutes.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 764 - 764
Published: Jan. 17, 2025
Marine
polysaccharide
hydrogels
have
emerged
as
an
innovative
platform
for
regulating
the
in
vivo
release
of
natural
bioactive
compounds
medical
purposes.
These
hydrogels,
which
exceptional
biocompatibility,
biodegradability,
and
high
water
absorption
capacity,
create
effective
matrices
encapsulating
different
molecules.
In
addition,
by
modifying
physical
chemical
properties
marine
including
cross-linking
density,
swelling
behavior,
response
to
external
stimuli
like
pH,
temperature,
or
ionic
strength,
profile
encapsulated
is
strictly
regulated,
thus
maximizing
therapeutic
efficacy
minimizing
side
effects.
Finally,
using
naturally
sourced
polysaccharides
hydrogel
formulations,
sustainability
promoted
reducing
dependence
on
synthetic
polymers,
meeting
growing
demand
eco-friendly
materials.
This
review
analyzes
interaction
between
offers
examples
how
molecules
can
be
encapsulated,
released,
stabilized.
Journal of Composites Science,
Journal Year:
2025,
Volume and Issue:
9(3), P. 133 - 133
Published: March 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Therapeutic Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: Jan. 27, 2025
Natural
hydrogels
have
garnered
increasing
attention
due
to
their
natural
origins
and
beneficial
roles
in
wound
healing.
Hydrogel
water-retaining
capacity
excellent
biocompatibility
create
an
ideal
moist
environment
for
healing,
thereby
enhancing
cell
proliferation
tissue
regeneration.
For
this
reason,
naturally
derived
formulated
from
biomaterials
such
as
chitosan,
alginate,
gelatin,
fibroin
are
highly
promising
biodegradability
low
immunogenic
responses.
Recent
integrated
approaches
utilizing
new
technologies
with
bioactive
agents
significantly
improved
the
mechanical
properties
of
controlled
release
delivery
active
compounds,
efficiency
treatment
processes.
Herein,
review
highlights
advantages
challenges
focusing
on
strength,
degradation
rates,
safety
validation,
potential
incorporating
advanced
engineering
gene
therapy
utilization
personalized
medicine.
Environmental Research,
Journal Year:
2023,
Volume and Issue:
243, P. 117889 - 117889
Published: Dec. 10, 2023
In
the
last
decade,
both
cellulose
and
alginate
polysaccharides
have
been
extensively
utilized
for
synthesis
of
biocompatible
hydrogels
because
their
alluring
characteristics
like
low
cost,
biodegradability,
hydrophilicity,
ease
availability
non-toxicity.
The
presence
abundant
hydrophilic
functional
groups
(like
carboxyl
hydroxyl)
on
surface
or
derivatives
makes
these
materials
promising
candidates
preparation
with
appealing
structures
characteristics,
leading
to
growing
research
in
water
treatment
biomedical
fields.
These
two
are
typically
blended
together
improve
hydrogels'
desired
qualities
(mechanical
strength,
adsorption
properties,
cellulose/alginate
yield).
So,
keeping
view
extensive
applicability,
present
review
article,
recent
advances
development
cellulose/nanocellulose-alginate-based
relevance
(adsorption
dyes,
heavy
metals,
etc.)
field
(wound
healing,
tissue
engineering,
drug
delivery)
has
reviewed.
Further,
impact
other
inorganic/organic
additives
properties
contaminants
adsorption,
delivery,
etc.,
also
studied.
Moreover,
current
difficulties
future
prospects
nanocellulose-alginate-based
regarding
purification
applications
discussed
at
end.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(10), P. 497 - 497
Published: Oct. 8, 2023
Within
the
human
body,
intricate
network
of
blood
vessels
plays
a
pivotal
role
in
transporting
nutrients
and
oxygen
maintaining
homeostasis.
Bioprinting
is
an
innovative
technology
with
potential
to
revolutionize
this
field
by
constructing
complex
multicellular
structures.
This
technique
offers
advantage
depositing
individual
cells,
growth
factors,
biochemical
signals,
thereby
facilitating
functional
vessels.
Despite
challenges
fabricating
vascularized
constructs,
bioprinting
has
emerged
as
advance
organ
engineering.
The
continuous
evolution
biomaterial
knowledge
provides
avenue
overcome
hurdles
associated
tissue
fabrication.
article
overview
biofabrication
process
used
create
vascular
constructs.
It
delves
into
various
techniques
engineering,
including
extrusion-,
droplet-,
laser-based
methods.
Integrating
these
prospect
crafting
artificial
remarkable
precision
functionality.
Therefore,
impact
engineering
significant.
With
technological
advances,
it
holds
promise
revolutionizing
transplantation,
regenerative
medicine.
By
mimicking
natural
complexity
vessels,
brings
us
one
step
closer
organs
vasculature,
ushering
new
era
medical
advancement.
The
environmental
impact
of
drug
manufacturing
raises
concerns
about
sustainability
in
healthcare.
To
address
this,
exploring
alternative
approaches
to
production
is
crucial.
This
review
focuses
on
seaweed
as
a
sustainable
resource
for
greening
processes.
Seaweed
offers
advantages
such
renewability,
abundance,
and
positive
footprint.
begins
by
providing
an
overview
practices
the
challenges
faced
achieving
sustainability.
It
then
discusses
resource,
including
cultivation
techniques
benefits.
has
various
applications
manufacturing,
extracting
purifying
bioactive
compounds
with
potential
therapeutic
properties.
Seaweed’s
role
developing
green
technologies,
seaweed-based
excipients,
biodegradable
packaging
materials,
source
energy
processes,
highlighted.
economic
implications
incorporating
solutions
are
discussed,
emphasizing
reduced
carbon
footprint
cost-effectiveness.
Regulatory
industrial
perspectives
addressed,
examining
challenges,
opportunities
implementing
manufacturing.
Collaboration
between
academia,
industry,
regulatory
bodies
crucial
successful
integration.
presents
future
directions
opportunities,
emerging
trends
innovations
areas
further
research,
policy
development,
industry
engagement
recommendations.
Incorporating
into
facilitates
reduction
impact,
promotes
efficiency,
contributes
showcases
means
foster
greener
addressing
concerns,
promoting
Infection and Drug Resistance,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 791 - 805
Published: March 1, 2024
Abstract:
Untreated
topical
infections
can
become
chronic,
posing
serious
health
issues.
Optimal
skin
adherence
is
crucial
in
addressing
such
infections.
In
this
context,
chitosan
and
alginate
emerge
as
promising
candidates
for
use
a
foundation
the
development
of
hydrogels.
The
aim
review
to
examine
literature
on
hydrogel
formulations
that
foundations,
specifically
context
antibacterial
agents.
research
methodology
involves
by
examining
articles
published
databases
PubMed,
Scopus,
ScienceDirect,
Google
Scholar.
keywords
employed
during
were
"Alginate",
"Chitosan",
"Hydrogel",
"Antibacterial".
Chitosan
serve
bases
hydrogels
deliver
various
active
ingredients,
particularly
agents,
indicated
search
results.
Both
have
demonstrated
significant
effectiveness,
evidenced
reduction
bacterial
colony
counts
an
increase
inhibition
zones.
This
strongly
supports
idea
could
be
used
together
make
kill
bacteria
work
well.
conclusion,
alginate-based
show
great
potential
treating
surface.
incorporation
into
aids
retaining
allowing
their
gradual
release
over
optimal
period.
Therefore,
formulated
with
solution
address
challenges
treatment
Keywords:
Alginate,
chitosan,
hydrogel,
topical,
agent
