Journal of Water Process Engineering, Год журнала: 2024, Номер 69, С. 106831 - 106831
Опубликована: Дек. 24, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1913 - 1913
Опубликована: Фев. 5, 2024
Natural products derived from medicinal plants offer convenience and therapeutic potential have inspired the development of antimicrobial agents. Thus, it is worth exploring combination nanotechnology natural products. In this study, silver nanoparticles (AgNPs) were synthesized leaf extract Ginkgo biloba (Gb), having abundant flavonoid compounds. The reaction conditions colloidal stability assessed using ultraviolet–visible spectroscopy. X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy (FTIR) used to characterize AgNPs. AgNPs exhibited a spherical morphology, uniform dispersion, diameter ranging ~8 9 nm. FTIR data indicated that phytoconstituents, such as polyphenols, flavonoids, terpenoids, could potentially serve reducing capping antibacterial activity was broth dilution agar well diffusion assays. results demonstrate effects against both Gram-positive Gram-negative strains at low AgNP concentrations. cytotoxicity examined in vitro CCK-8 method, which showed concentrations are noncytotoxic normal cells promote cell growth. conclusion, an environmentally friendly approach for synthesizing Gb leaves yielded with minimal toxicity, holding promise future applications field biomedicine.
Язык: Английский
Процитировано
11
Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(47), С. 57765 - 57777
Опубликована: Сен. 18, 2024
Synthesis of silver nanoparticles (Ag NPs) using microalgae is gaining recognition for its environmentally friendly and cost-effective nature while maintaining high activity NPs. In the present study, Ag NPs were synthesized a methanolic extract Chlorella vulgaris subjected to calcination. The X-ray diffraction (XRD) analysis showed crystalline products with
Язык: Английский
Процитировано
9
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(5), С. 4731 - 4741
Опубликована: Фев. 19, 2024
In the present scenario, resistance to antibiotics has become a threatening situation for public health. To find solution this, conjugation of cationic peptide with silver nanoparticles is emerging as promising route attain enhanced antibacterial activity. this direction, work reports synthesis lysine-based (BP100: NH2–KKLFKKILKYL–amide) functionalized (BP100@AgNPs). The interacts electrostatically in an aqueous medium. developed nanosystem followed green chemistry principles, owing use water and one-step strategy nanoparticles. Moreover, BP100@AgNPs were characterized by UV–vis spectroscopy, zeta potential analysis, FTIR, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD). addition order have deeper insight into interaction between BP100 nanoparticles, NMR (BP100) (BP100@AgNPs) was carried out. This further authenticated 1D (1H,13C) 2D (1H-COSY (correlation spectroscopy)), 13C-HSQC (heteronuclear single quantum coherence)). tested activity against Gram-negative (E. coli) Gram-positive (S. aureus) bacterial strains. displayed good inhibition MIC values 3.60 13.20 μg/mL E. coli S. aureus, respectively. destruction cellular membrane cells upon treatment observed via field emission scanning (FESEM) which confirmed efficient nanosystem. Hence, synthesized considerable be used excellent candidate applications.
Язык: Английский
Процитировано
8
BioNanoScience, Год журнала: 2025, Номер 15(2)
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Дек. 20, 2023
Abstract In this study, a novel core/shell nanocomposite structure ( h -BN@Gd 2 O 3 NCs) was created for the first time by combining hexagonal boron nitride -BN) with doped gadolinium oxide (Gd ) using different laser pulse numbers, i.e., 150, 338, and 772 pulses. We employed various analytical techniques, including mapping analysis, FE-SEM, EDS, HRTEM, SAED, XRD, zeta potential DLS, FTIR, Raman spectroscopy, PL measurements, to characterize synthesized -BN, c -Gd , NCs (338 pulses). XRD results indicated cubic crystal structures BN Gd respectively, while EDS confirmed their chemical composition elemental mapping. Chemical bonds between B–N–Gd, B–N–O, Gd–O bands at 412, 455, 474, 520 cm −1 were identified FTIR analysis. The antimicrobial anticancer activities of these agar well diffusion MTT assays. They exhibited potent antibacterial properties against both Gram-positive Gram-negative pathogens. Furthermore, have reduced proliferation cancerous cells, human colon adenocarcinoma cells (HT-29) breast cancer (MCF-7), not affecting normal cell line (MCF-10). efficacy validated AO/EtBr assay, which apoptotic death. Blood compatibility on erythrocytes also hemolytic in vitro toxicity assessments. compiled study proposed nanoparticles could be used as promising drug delivery system potentially healthcare applications.
Язык: Английский
Процитировано
18
Sustainability, Год журнала: 2024, Номер 16(20), С. 8758 - 8758
Опубликована: Окт. 10, 2024
The development of efficient photocatalysts is crucial in addressing water pollution concerns, specifically the removal organic dyes from wastewater. In this context, use silver nanoparticles (Ag NPs) might represent a method to achieve high dye degradation efficiencies. On other hand, classical Ag NP production process involves several reactants and operating conditions, which make it poorly sustainable. present work, NPs were synthesized according new sustainable involving natural extracts Spirulina platensis milder conditions. material was also calcined determine influence content on properties NPs. X-ray diffraction (XRD) analysis displayed AgCl phases with crystalline size 11.79 nm before calcination. After calcination, only phase an increased 24.60 nm. Fourier Transform Infrared Spectroscopy (FTIR) confirmed capping role metabolites extract. Scanning Electron Microscopy (SEM) Transmission (TEM) revealed spherical or quasi-spherical morphologies agglomeration due Energy-dispersive spectroscopy (EDX) Thermogravimetric (TGA) analyses further involvement synthesis optical changes products observed UV-Vis analysis. tested for their photocatalytic activity against laboratory brilliant blue r visible light various highest efficiency 81.9%, kapp value 0.00595 min−1, alkaline medium after 90 min irradiation.
Язык: Английский
Процитировано
7
Chemical Communications, Год журнала: 2024, Номер 60(29), С. 3874 - 3890
Опубликована: Янв. 1, 2024
The simple biofabrication of microalgae-assisted nanomaterials offers a versatile option with far-reaching implications, effectively addressing sustainability challenges, environmental pollution, biomedical and dynamic needs the society.
Язык: Английский
Процитировано
6
Marine Drugs, Год журнала: 2024, Номер 22(12), С. 549 - 549
Опубликована: Дек. 4, 2024
The green synthesis of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs), as well Ag/Ag2O/ZnO nanocomposites (NCs), using polar apolar extracts Chlorella vulgaris, offers a sustainable method for producing nanomaterials with tunable properties. impact the environment nanomaterials’ characteristics on cytotoxicity was evaluated by examining reactive species production their effects mitochondrial bioenergetic functions. Cytotoxicity assays PC12 cells, cell line originated from rat pheochromocytoma, an adrenal medulla tumor, demonstrated that Ag/Ag2O NPs synthesized (Ag/Ag2O A) P) exhibited significant cytotoxic effects, primarily driven Ag+ ion release disruption function. However, it is more likely organic content, rather than size, influenced anticancer activity, commercial Ag NPs, despite smaller crystallite sizes, exhibit less effective activity. ZnO P showed increased oxygen (ROS) generation, correlated higher cytotoxicity, while A produced lower ROS levels, resulting in diminished effects. comparative analysis revealed differences LD50 values toxicity profiles. Differentiated cells resistance to ZnO, AgNPs Ag/Ag2O-based materials had similar both types. This study emphasizes crucial role bioactive compounds C. vulgaris modulating nanoparticle surface chemistry, cytotoxicity. results provide valuable insights designing safer biomedical applications, especially targeting tumor-like exploring relationships between polarity, capping agents, nanocomposite structures.
Язык: Английский
Процитировано
6
ACS Applied Nano Materials, Год журнала: 2023, Номер 6(19), С. 17581 - 17592
Опубликована: Сен. 20, 2023
The development of efficient drug formulations for Parkinson's disease (PD) treatment is challenged by achieving pharmacokinetic profiles, reduced side effects, and better permeability through the blood–brain barrier (BBB). As nanoparticles may facilitate delivery drugs in brain due to their high-loading capacity ability cross biological barriers, we designed two different types selenium (SeNPs) that increase transport across BBB act as antioxidants at site action. SeNPs were functionalized with polyvinylpyrrolidone (PVP) polysorbate 20 (Tween) characterized terms size, size distribution, shape, surface charge, colloidal stability relevant media. Their drug-loading was tested using dopamine l-DOPA therapeutically active agents PD. Thermodynamic analysis revealed binding processes occurred spontaneously hydrogen bond/van der Waals interactions or electrostatic interactions. strongest interaction observed between PVP-SeNPs dopamine, which a constant several orders magnitude higher than Tween-SeNPs. However, addition human transferrin model plasma protein significantly this difference, indicates crucial role corona formation design nanodelivery systems. In vitro evaluation cell-free cellular transwell models showed internalization SeNP-loaded l-DOPA/dopamine endothelial cells, while facilitated l-DOPA, achieved PVP-SeNPs. Overall, high potential drug-delivery vehicles PD demonstrated.
Язык: Английский
Процитировано
13