Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 2078 - 2078

Published: July 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Language: Английский

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Flavonoids and their role in oxidative stress, inflammation, and human diseases

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111489 - 111489

Published: March 1, 2025

Oxidative stress and chronic inflammation are important drivers in the pathogenesis progression of many diseases, such as cancers breast, kidney, lung, others, autoimmune diseases (rheumatoid arthritis), cardiovascular (hypertension, atherosclerosis, arrhythmia), neurodegenerative (Alzheimer's disease, Parkinson's Huntington's disease), mental disorders (depression, schizophrenia, bipolar disorder), gastrointestinal (inflammatory bowel colorectal cancer), other disorders. With increasing demand for less toxic more tolerable therapies, flavonoids have potential to effectively modulate responsiveness conventional therapy radiotherapy. Flavonoids polyphenolic compounds found fruits, vegetables, grains, plant-derived beverages. Six twelve structurally different flavonoid subgroups dietary significance include anthocyanidins (e.g. pelargonidin, cyanidin), flavan-3-ols epicatechin, epigallocatechin), flavonols quercetin, kaempferol), flavones luteolin, baicalein), flavanones hesperetin, naringenin), isoflavones (daidzein, genistein). The health benefits related their structural characteristics, number position hydroxyl groups presence C2=C3 double bonds, which predetermine ability chelate metal ions, terminate ROS radicals formed by Fenton reaction), interact with biological targets trigger a response. Based on these can exert both antioxidant or prooxidant properties, activity ROS-scavenging enzymes expression activation proinflammatory cytokines (e.g., interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α)), induce apoptosis autophagy, target key signaling pathways, nuclear factor erythroid 2-related 2 (Nrf2) Bcl-2 family proteins. This review aims briefly discuss mutually interconnected aspects oxidative inflammatory mechanisms, lipid peroxidation, protein oxidation, DNA damage, mechanism resolution inflammation. major part this article discusses role alleviating inflammation, two common components human diseases. results epidemiological studies also presented.

Language: Английский

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Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 231 - 231

Published: Feb. 8, 2025

Colorectal cancer (CRC) represents one of the most serious health issues and third commonly diagnosed worldwide. However, treatment options for CRC are associated with adverse reactions, in some cases, resistance can develop. Flavonoids have emerged as promising alternatives prevention therapy due to their multitude biological properties ability target distinct processes involved pathogenesis. Their innate disadvantageous (e.g., low solubility stability, reduced bioavailability, lack tumor specificity) delayed potential inclusion flavonoids regimens but hastened design nanopharmaceuticals comprising a flavonoid agent entrapped nanosized delivery platform that not only counteract these inconveniences also provide an augmented therapeutic effect elevated safety profile by conferring targeted action. Starting brief presentation pathological features overview classes, present study comprehensively reviews anti-CRC activity different from mechanistic perspective while portraying latest discoveries made area flavonoid-containing nanocarriers proved efficient management. This review concludes showcasing future perspectives advancement flavonoid-based research.

Language: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

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Potential Applications of the Anti-Inflammatory, Antithrombotic and Antioxidant Health-Promoting Properties of Curcumin: A Critical Review

Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(4), P. 562 - 595

Published: Oct. 11, 2024

The major constituent of turmeric, curcumin, is a bioactive phenolic compound that has been studied for its potential health benefits and therapeutic properties. Within this article, the anti-inflammatory, antioxidant antithrombotic properties mechanisms action curcumin are thoroughly reviewed main focus shifted to associated health-promoting effects against inflammation-related chronic disorders. An overview cardio-protective, anti-tumor, anti-diabetic, anti-obesity, anti-microbial neuro–protective reviewed, while relative outcomes obtained from clinical trials also presented. Emphasis given wound-healing as presented by several studies trials, which further promote application ingredient in functional products, including foods, nutraceuticals, cosmetics drugs. Limitations future perspectives such uses bio-functional discussed.

Language: Английский

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Microencapsulation of green tea polyphenols: Utilizing oat oil and starch-based double emulsions for improved delivery

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133295 - 133295

Published: June 22, 2024

The stability and bioavailability of green tea polyphenols, crucial for their health benefits, are compromised by environmental sensitivity, limiting use in functional foods supplements. This study introduces a novel water-in-oil-in-water double emulsion technique with microwave-assisted extraction, significantly enhancing the these compounds. primary objective this was to assess effectiveness several encapsulating agents, such as gum Arabic control native modified starches, improving encapsulated substances' release control. Native starches were chosen outstanding film-forming properties, encapsulation efficiency protecting bioactive compounds from oxidative degradation. combination maltodextrin tapioca starch improved phenolic content retention, giving 46.25 ± 2.63 mg/g microcapsules (GTTA) 41.73 3.24 arabic (GTGA). Besides control, also had most potent antioxidant activity, 45 % inhibition (inh%) DPPH analysis. Oat oil utilized its superior viscosity nutritional profile, boosting providing integrity indicated microcapsules' narrow span index (1.30 0.002). thermal behavior structural confirmed using advanced methods Differential Scanning Calorimetry (DSC) Fourier-Transform Infrared Spectroscopy (FT-IR). highlights critical role choosing appropriate wall materials extraction techniques. It sets new standard microencapsulation applications food industry, paving way future innovations.

Language: Английский

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Green synthesis of silver and gold nanoparticles using quercetin extracted from Arctium lappa by HPLC, Characterization and Estimation of antioxidant activity

Results in Chemistry, Journal Year: 2025, Volume and Issue: 13, P. 102028 - 102028

Published: Jan. 1, 2025

Language: Английский

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Identification of Natural Phytochemicals as AKT2 Inhibitors Using Molecular Docking and Dynamics Simulations as Potential Cancer Therapeutics

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41897 - e41897

Published: Jan. 1, 2025

The PI3K/AKT/mTOR pathway is central in regulating key cellular processes such as proliferation, survival, metabolism, and angiogenesis. Dysregulation of this pathway, particularly the AKT2 isoform, commonly observed cancers breast, ovarian, pancreatic cancers, leading to enhanced tumor progression, metastasis, therapeutic resistance. Therefore, targeting for inhibition a promising strategy cancer therapy. This study utilized molecular docking dynamics simulations identify natural phytochemicals that inhibit AKT2. Molecular results revealed millettone (CID 442810) exhibited highest binding affinity AKT2, with score -9.5 kcal/mol, followed by uzarigenin 92760), dihydrobiochanin A 439784), abyssinone I 442152) scores -9.0 -8.9 -8.7 kcal/mol respectively, outperforming control inhibitor, ipatasertib 24788740) -7.56 kcal/mol. indicated millettone, uzarigenin, demonstrated strong affinities stable interactions suggesting their potential agents involve hyperactivation. Notably, uzarigenin's superior stability, evidenced its lower root mean square deviation (RMSD), which measures structural solvent-accessible surface area (SASA), indicates compactness, highlights promise potent inhibitor Future vitro vivo studies will be crucial confirm efficacy these inhibitors reducing progression applications. Given also plays role neuronal survival plasticity, compounds may have applications neurodegenerative diseases Alzheimer's, warranting further investigation into dual relevance.

Language: Английский

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Cirsiliol suppresses the proliferation of human oral cancer cells by targeting topoisomerase I

3 Biotech, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 21, 2025

Language: Английский

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Anticancer Potential of Flavonoids: Their Role in Cancer Prevention and Health Benefits

Foods, Journal Year: 2024, Volume and Issue: 13(14), P. 2253 - 2253

Published: July 17, 2024

The term "flavonoid" encompasses a group of plant compounds, predominantly flavonoids, present in fruits, vegetables, and other plant-based foods. These compounds deliver significant health benefits, including potent antioxidant properties that protect cells from free radicals, thereby mitigating aging disease. We assessed study quality bias using the Cochrane Risk Bias tool Newcastle-Ottawa Scale. Inclusion criteria specified studies must examine natural flavonoid involve animal or human trials, be original studies, English articles on flavonoid's cancer-prevention effects, excluding conference abstracts single-case studies. conducted comprehensive search major databases PubMed, Web Science, Embase, SCOPUS, Google Scholar, reviewing six clinical trials with total sample sizes over 50 to 1500 participants. results indicate consuming flavonoid-rich fruits can aid cancer prevention by targeting angiogenic cancer-protective pathways. specifically selected tomatoes, mulberries, Amazon grapes, apples, citrus due their well-documented high levels flavonoids robust evidence supporting physiological effects. In particular, contain additional beneficial phytochemicals complement action enhancing overall anti-cancer mechanisms are not well-defined scientific literature, suggesting gap this aims address. Our provides novel contributions demonstrating how supplementation induces effects through angiogenesis, anti-inflammatory actions, antioxidant-induced apoptosis, modulation pathways like PI3K/Akt MAPK. were particularly notable progression breast, colon, liver, lung cancers, statistical significance (

Language: Английский

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