A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak

Viruses, Год журнала: 2022, Номер 14(9), С. 1870 - 1870

Опубликована: Авг. 25, 2022

Monkeypox disease (MPX) is currently considered a global threat after COVID-19. European Medicines Agency (EMA) approved Tecovirimat in capsule dosage form (200 mg) as the first treatment for MPX January 2022. This article highlights Tecovirimat’s development and patent literature review believed to benefit scientists working on developing treatments. The was gathered from website of SIGA Technologies (developer Tecovirimat), regulatory agencies (EMA, United States Food Drug Administration (USFDA), Health Canada), PubMed, freely accessible clinical/patent databases. recognized an anti-orthopoxvirus molecule 2002 developed by Technologies. USFDA Canada have also recently treat smallpox 2018 2021, respectively. efficacy verified infected non-human primates (monkeys) rabbits under USFDA’s Animal Rule. Most clinical studies been done safety pharmacokinetic parameters. has revealed inventions related capsule, injection, suspension, crystalline forms, amorphous form, drug combinations (Tecovirimat + cidofovir) process preparing Tecovirimat. authors foresee off-label use USA other orthopoxvirus infections. trust that there immense scope new Tecovirimat-based treatments (new with antivirals) viral diseases. interaction resistance are recommended. handle current outbreak hope biosecurity against or orthopoxvirus-related bioterrorism attack.

Язык: Английский

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Role of dietary supplements in the continuous battle against COVID‐19

Phytotherapy Research, Год журнала: 2024, Номер 38(2), С. 1071 - 1088

Опубликована: Янв. 2, 2024

Abstract A sudden outbreak of the COVID‐19 pandemic was a big blow to world community on every level. Created by novel coronavirus, SARS‐CoV‐2, which previously unknown human immune system. The expert opinion almost immediately united fact that most effective way fighting would be building immunity artificially via mass immunization program. However, it took about year for approval first vaccine against COVID‐19. In meantime, part general population started adapting nutritious diet plans and dietary supplements boost natural as potential prophylactic strategy SARS‐CoV‐2 infection. Whether they originate from mainstream medicine, such synthetic supplements, or traditional herbal remedies in form single poly‐herbs, these may comprise various components exhibit immunomodulatory, anti‐inflammatory, antioxidant, antimicrobial characteristics. There is substantial body predictions opinions suggesting enhancing one's with containing additional nutrients bioactive compounds like vitamins, minerals, amino acids, fatty phytochemicals, probiotics can enhance system's ability develop resistance COVID‐19, although none them have any conclusive evidence nor officially recommended World Health Organization (WHO). current review critically acclaims gap between public perception‐based preference real evidence‐based study weigh actual benefit relation prevention management.

Язык: Английский

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Impact of selenium nanoparticles in the regulation of inflammation

Archives of Biochemistry and Biophysics, Год журнала: 2022, Номер 732, С. 109466 - 109466

Опубликована: Ноя. 17, 2022

Язык: Английский

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Selenium and COVID-19: A spotlight on the clinical trials, inventive compositions, and patent literature

Journal of Infection and Public Health, Год журнала: 2022, Номер 15(11), С. 1225 - 1233

Опубликована: Окт. 4, 2022

Selenium is an indispensable trace element for all living organisms. It essential structural component of several selenium-dependent enzymes, which support the human body's defense mechanism. Recently, significance selenium in preventing/treating COVID-19 has been documented literature. This review highlights clinical studies, compositions, and patent literature on to prevent/treat COVID-19. exerts its anti-COVID-19 action by reducing oxidative stress, declining expression ACE-2 receptor, lowering discharge pro-inflammatory substances, inhibiting 3CL

Язык: Английский

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Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature

Microorganisms, Год журнала: 2024, Номер 12(2), С. 332 - 332

Опубликована: Фев. 4, 2024

Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive thrombus formation. However, recent shown naringenin naringin palliative on various COVID-19 sequelae. Flavonoids naringenin, commonly in fruits vegetables, positive effects, including reducing inflammation, preventing viral providing antioxidants. This article discusses the molecular mechanisms clinical treating above diseases. It proposes them potential drugs for treatment COVID, it inferred exhibit extended medications, future likely serving nutraceuticals or supplements comprehensive alleviation manifestations complications.

Язык: Английский

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Effect of organic amendments on sustainable production, quality and soil fertility in nigella (Nigella sativa L.)

Discover Agriculture, Год журнала: 2025, Номер 3(1)

Опубликована: Март 26, 2025

Abstract The over use of chemical fertilizers and other synthetic inorganic agri-inputs has led to air pollution, groundwater contamination, soil organic matter loss, a decline in crop quality. Environmental sustainability declined as result agri-food production systems' over-reliance on agrochemicals. Nigella is one the important seed spices got place among top-ranked evidence-based herbal medicines. Many food pharmaceutical firms prefer products that are cultivated organically. Hence, an attempt been made towards sustainable nigella by amendments for nutrition. experiment comprised 14 treatments including control supply recommended dose nitrogen through amendments. holistic assessment results confirmed 100% (40 kg ha −1 ) alone application farmyard manure (8 t could be ideal amendment nutrition view optimum yield (923 ), harvest index (20.05%), (0.77) carbon (0.242%) tested arid semi-arid regions India. Practicing this, development goals achieved some extent. Besides, combined manure, vermi-compost neem-cake 33.3% each was found promising interest oil yield.

Язык: Английский

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Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 1917 - 1932

Опубликована: Май 1, 2024

Abstract: The oral cavity is an excellent place for various microorganisms to grow. Spectrococcus mutans and sanguinis are Gram-negative bacteria found in the as pioneer biofilm formers on tooth surface that cause caries. Caries treatment has been done with antibiotics therapeutics, but resistance level of S. necessitates exploration new drug compounds. Black cumin ( Nigella sativa Linn.) known contain secondary metabolites have antioxidant, antibacterial, anti-biofilm, anti-inflammatory antifungal activities. purpose this review article present data potential Linn seeds anti-biofilm. This will discuss biofilm-forming bacteria, mechanism antibiotics, bioactivity N. extracts seed isolates together Structure Activity Relationship (SAR) compound isolates. We collected from reliable references illustrate anti-biofilm drug. Keywords: Linn, dental caries, ,

Язык: Английский

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The effect of Nigella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients: A randomized controlled clinical trial

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 8, 2022

Background: The coronavirus disease 2019 (COVID-19) is a novel that causes severe infection in the respiratory system. Since immune status plays an essential role combating COVID-19, herbal medicines, which have immunomodulatory effect, may help prevent and even treat COVID-19. Nigella sativa one of medicines with antiviral activities, its therapeutic effectiveness makes it promising add-on therapy for In addition, vitamin D3 has role, but effect supplementation SARS-CoV-2 still not well-known. Objective: This study aims to investigate effects as single supplemental therapies combination on viral clearance indicated by negative polymerase chain reaction alleviation symptoms during follow-up duration 14 days. Patients Methods: design was open-label randomized controlled clinical trial conducted at Respiratory Hospital Kobry El Qobba Armed Forces Medical Complex. total, 120 COVID-19 patients mild moderate were randomly assigned four groups, thirty each, follows: Group 1 received oral dose 900 mg through 450 soft gelatin capsules twice daily two weeks; 2 2,000 IU 1000-IU tablets given tablets, once daily; 3 same manner dosing previous groups; 4 control group. All groups standard infections management COVID-19’s symptoms. Results: –vitamin addition significantly contributed most symptoms: 50% free cough after 7 days, 70% showed absence fatigue 80% had no headache 5 90% rhinorrhea 86.7% dyspnea Moreover, studied reduced median temperature days treatment. Negative results (PCR) test recorded 7th 14th day superior arm compared those other arms where value odds ratio (OR) 0.13 95% CI: 0.03–0.45 0.09 0.02–0.3. Conclusion: this benefit administration Additionally, remarkable short time interval reduction severity progression recommended use patients. Clinical Trial Registration: ClinicalTrials.gov , Identifier: NCT04981743.

Язык: Английский

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EXPLORING THE POTENTIAL OF HERBAL THERAPY IN COVID-19

International Journal of Current Pharmaceutical Research, Год журнала: 2023, Номер unknown, С. 50 - 60

Опубликована: Ноя. 15, 2023

The world has been facing the deadly coronavirus for a stretch of period now and with innovation latest research, development vaccines possible. initial duration wherein were under trials most opted choice was use modern drug like Remdesivir along other existing daily supplements. This review article describes various pathogenic mechanism action by which virus attacks replicates inside body. It briefly gives role allopathy drugs, traditional Ayurvedic medicines herbs act discrete mechanism. also focuses on acting as drugs supplements could be prophylactic hence used management mild to moderate COVID conditions. Herbal agents Ocimum sanctum, Curcuma longa, Withaniasomnifera, Glycyrrhiza glabra, Andrographis paniculata, Zingiber officinale etc. can have different antiviral actions during COVID-19 outbreak shown good margin efficacy. Phytoconstituents quercetin, fenugreek, liquorice activities anti-viral, anti-inflammatory, immunomodulatory action, is studied further in silico modelling molecular docking. significant these phytoconstituents contributed preventive described.

Язык: Английский

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Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice

Biology, Год журнала: 2024, Номер 13(12), С. 1035 - 1035

Опубликована: Дек. 11, 2024

Colitis, an inflammatory condition of the colon that encompasses ulcerative colitis (UC) and Crohn's disease, presents significant challenges due to limitations side effects current treatments. This study investigates potential natural products, specifically AH NSO, as organic therapeutic agents for colitis. Molecular docking studies were conducted identify binding affinities interaction mechanisms between bioactive compounds in NSO proteins implicated colitis, such those involved inflammation oxidative stress pathways. An vivo experiment was performed using albino mouse model with clinical symptoms, histopathological assessments, biochemical analyses evaluate both individually combination. Results from molecular revealed promising interactions fructose Prostaglandin G/H synthase 2 (Ptgs2) cellular tumor antigen p53, energy measured at -6.0 kcal/mol -5.1 kcal/mol, respectively. Meanwhile, presence glucose molecule glucokinase chain A (-6.3 kcal/mol) B (-5.8 indicated efficacy modulating Experimental data demonstrated treatment significantly reduced inflammation, improved gut health, ameliorated symptoms. Histopathological evaluations confirmed mucosal damage immune cell infiltration, while showed normalization markers levels. provides compelling evidence natural, complementary treatments suggesting their future role integrative strategies. However, further research into long-term safety, optimal dosing, action is warranted translate these findings applications.

Язык: Английский

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