Meditsinskiy sovet = Medical Council,
Год журнала:
2023,
Номер
17(9), С. 40 - 46
Опубликована: Июнь 24, 2023
In
the
prescriptions
of
an
endocrinologist
to
patients
with
diabetes
mellitus,
glucagon-like
peptide
agonists,
belonging
group
that
affects
incretin
system
body,
have
recently
been
increasingly
appearing.
addition
pronounced
hypoglycemic
effect
and
high
safety,
these
drugs
also
many
pleiotropic
properties
due
presence
receptors
in
vascular
endothelium,
kidneys,
heart
nervous
tissue.
The
purpose
this
work
is
describe
most
studied
neuroprotective
effects
class
drugs.
As
materials
course
work,
studies
domestic
foreign
colleagues
published
period
from
2008
2022
were
used.
Our
has
shown
GLP-1
associated
activation
corresponding
receptor
systems
central
system,
which
leads
increased
cellular
survival
ischemic
conditions
by
reducing
reactive
oxygen
species,
stimulating
beta-oxidation
mitochondria,
pro-inflammatory
cytokines.
addition,
analysis
literature
established
positive
role
neurodegenerative
diseases
–
reduce
amount
unnormal
proteins
(alphasynuclein,
microtubular
T-peptide,
etc.),
activity
non-enzymatic
glycation
hyperglycemia,
as
well
insulin
resistance.
described
above
analyzed
during
preclinical
trials
GLP-1,
demonstrated
their
validity
human
models
some
clinical
trials.
However,
data
obtained
not
yet
sufficient
form
clear
indications
for
neurology,
so
topic
requires
further
study
large
Heliyon,
Год журнала:
2024,
Номер
10(1), С. e24050 - e24050
Опубликована: Янв. 1, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
fatal
neurodegenerative
disease
that
causes
significant
neurodegeneration.
Methylmercury
(MeHg)
neurotoxin
induces
axonal
neurodegeneration
and
motor
nerve
degeneration
by
destroying
oligodendrocytes,
degenerating
white
matter,
inducing
apoptosis,
excitotoxicity,
reducing
myelin
basic
protein
(MBP).
This
study
examines
the
inhibition
of
SIRT-1
(silence
information
regulator
1),
Nrf-2
(nuclear
factor
E2-related
2),
HO-1
(heme
oxygenase
TDP-43
(TAR-DNA-binding
43)
accumulation
in
context
ALS,
as
well
modulation
these
proteins
icariin
(15
30
mg/kg,
orally),
glycoside
flavonoid
with
neuroprotective
properties.
Neuroprotective
activates
SIRT-1,
Nrf-2,
HO-1,
mitigating
inflammation
neuronal
injury
disorders.
In-vivo
in-silico
testing
experimental
ALS
models
confirmed
efficacy
modulating
cellular
targets.
The
addition
sirtinol
10
an
inhibitor
helps
determine
effectiveness
icariin.
In
this
study,
we
also
examined
neurobehavioral,
neurochemical,
histopathological,
LFB
(Luxol
fast
blue)
markers
various
biological
samples,
including
Cerebrospinal
fluid
(CSF),
blood
plasma,
brain
homogenates
(Cerebral
Cortex,
Hippocampus,
Striatum,
mid-brain,
Cerebellum).
These
results
demonstrate
administration
ameliorates
mechanism
underlying
benefits
likely
related
to
regulating
signaling
pathways.
Genes,
Год журнала:
2022,
Номер
13(8), С. 1324 - 1324
Опубликована: Июль 25, 2022
Multiple
sclerosis
(MS)
is
a
severe
immune-mediated
neurological
disease
characterized
by
neuroinflammation,
demyelination,
and
axonal
degeneration
in
the
central
nervous
system
(CNS).
This
frequently
linked
to
motor
abnormalities
cognitive
impairments.
The
pathophysiological
hallmarks
of
MS
include
inflammatory
injury,
white
matter
degeneration,
development
CNS
lesions
that
result
neuronal
degeneration.
Several
studies
suggested
downregulation
nuclear
factor
erythroid-2-related
factor-2
(Nrf2)/Heme
oxygenase-1
(HO-1)
signaling
causative
for
pathogenesis.
Acetyl-11-keto-β-boswellic
acid
(AKBA)
an
active
pentacyclictriterpenoid
obtained
from
Boswellia
serrata,
possessing
antioxidant
anti-inflammatory
properties.
present
study
explores
protective
potential
AKBA
on
behavioral,
molecular,
neurochemical,
gross
pathological
abnormalitiesandhistopathological
alterations
H&E
LFB
staining
techniques
experimental
model
multiple
sclerosis,
emphasizing
increase
inNrf2/HO-1
levels
brain.
Moreover,
we
also
examine
effect
intensity
myelin
basic
protein
(MBP)
CSF
rat
brain
homogenate.
Specific
apoptotic
markers
(Bcl-2,
Bax,
andcaspase-3)
were
estimated
Neuro
behavioralabnormalities
rats
examined
using
actophotometer,
rotarod
test,
beam
crossing
task
(BCT),and
Morris
water
maze
(MWM).
50
mg/kg
100
given
orally
day
8
35
alleviate
symptoms
EB-injected
rats.
Furthermore,
cellular,
neurotransmitter,
neuroinflammatory
cytokine,
oxidative
stress
whole
homogenate,
blood
plasma,
cerebral
spinal
fluid
investigated.
shows
upregulates
level
proteins
such
as
Nrf2
HO-1
restores
altered
neurochemical
levels,
potentially
preventing
during
progression.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 7, 2022
Central
nervous
system
(CNS)
disorders
and
diseases
are
expected
to
rise
sharply
in
the
coming
years,
partly
because
of
world’s
aging
population.
Medicines
for
treatment
CNS
have
not
been
successfully
made.
Inadequate
knowledge
about
brain,
pharmacokinetic
dynamic
errors
preclinical
studies,
challenges
with
clinical
trial
design,
complexity
variety
human
brain
illnesses,
variations
species
some
potential
scenarios.
Neurodegenerative
(NDDs)
multifaceted
lack
identifiable
etiological
components,
drugs
developed
treat
them
did
meet
requirements
those
who
anticipated
treatments.
Therefore,
there
is
a
great
demand
safe
effective
natural
therapeutic
adjuvants.
For
NDDs
other
memory-related
problems,
many
herbal
items
used
Ayurvedic
medical
system.
Anxiety,
depression,
Parkinson’s,
Alzheimer’s
(AD),
as
well
plethora
neuropsychiatric
disorders,
may
benefit
from
use
plant
food-derived
chemicals
that
antidepressant
or
antiepileptic
properties.
We
summarized
present
level
products
based
on
topological
evidence,
bioinformatics
analysis,
translational
research
this
review.
also
highlighted
investigation
will
help
us
select
neurological
conditions.
In
review,
we
explored
efficacy
phytoconstituents
against
diseases.
Various
evidence-based
studies
extensive
recent
investigations
included,
which
pharmacologists
reduce
progression
neuronal
disease.
Biomedicines,
Год журнала:
2022,
Номер
10(11), С. 2866 - 2866
Опубликована: Ноя. 9, 2022
Huntington's
disease
(HD)
is
distinguished
by
a
triple
repeat
of
CAG
in
exon
1,
an
increase
poly
Q
the
Htt
gene,
and
loss
GABAergic
medium
spiny
neurons
(MSN)
striatum
white
matter
cortex.
Mitochondrial
ETC-complex
dysfunctions
are
involved
pathogenesis
HD,
including
neuronal
energy
loss,
synaptic
neurotrophic
decline,
inflammation,
apoptosis,
grey
destruction.
A
previous
study
has
demonstrated
that
beta
Boswellic
acid
(β-BA),
naturally
occurring
phytochemical,
several
neuroprotective
properties
can
reduce
pathogenic
factors
associated
with
various
neurological
disorders.
The
current
investigation
aimed
to
investigate
potential
β-BA
at
oral
doses
5,
10,
15
mg/kg
alone,
as
well
conjunction
potent
antioxidant
vitamin
E
(8
mg/kg,
orally)
3-NP-induced
experimental
HD
rats.
Adult
Wistar
rats
were
separated
into
seven
groups,
3-NP,
dose
10
was
orally
administered
each
group
adult
beginning
on
day
1
continuing
through
14.
neurotoxin
3-NP
induces
neurodegenerative,
g,
neurochemical,
pathological
alterations
animals.
Continuous
injection
according
our
results,
aggravated
symptoms
suppressing
ETC-complex-II,
succinate
dehydrogenase
activity,
neurochemical
alterations.
β-BA,
when
taken
E,
improved
behavioural
such
neuromuscular
motor
impairments,
memory
cognitive
abnormalities.
Pharmacological
treatments
restored
ETC
complexes
enzymes
I,
II,
V
levels
brain
homogenates.
treatment
also
neurotransmitter
while
lowering
inflammatory
cytokines
oxidative
stress
biomarkers.
β-BA's
reducing
death
supported
histopathological
findings
As
result,
this
research
contributed
better
understanding
role
natural
phytochemicals
preventing
illnesses
HD.
Molecules,
Год журнала:
2022,
Номер
27(22), С. 7951 - 7951
Опубликована: Ноя. 17, 2022
Parkinson's
disease
(PD)
is
characterised
by
dopaminergic
neuronal
loss
in
the
brain
area.
PD
a
complex
that
deteriorates
patients'
motor
and
non-motor
functions.
In
experimental
animals,
neurotoxin
6-OHDA
induces
neuropathological,
behavioural,
neurochemical
mitochondrial
abnormalities
formation
of
free
radicals,
which
related
to
Parkinson-like
symptoms
after
inter-striatal
injection.
Pathological
manifestations
disrupt
cAMP/ATP-mediated
activity
transcription
factor
CREB,
resulting
Parkinson's-like
symptoms.
Forskolin
(FSK)
direct
AC/cAMP/CREB
activator
isolated
from
