Food Bioscience, Год журнала: 2023, Номер 57, С. 103493 - 103493
Опубликована: Дек. 20, 2023
Язык: Английский
Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)
Опубликована: Янв. 16, 2024
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration worsening symptoms. Adenosine deaminase (ADA), enzyme in purine metabolism, influences adenosine levels inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases hypoxic inflammatory conditions. Lymphocytes with play a role RA. lymphocytic activity has immune-regulatory effect. Synovial fluid of are closely associated the disease’s systemic activity, making it useful parameter for evaluating Flavonoids, such as quercetin (QUE), natural substances that can inhibit activity. QUE demonstrates effects restores T-cell homeostasis, promising candidate therapy. In this review, we will explore suppressing reducing produced inflammation RA, including preclinical investigations clinical trials. Graphical
Язык: Английский
Процитировано
5
Foods, Год журнала: 2024, Номер 13(6), С. 830 - 830
Опубликована: Март 8, 2024
The aim of this work is to describe the effect convective drying (CD), vacuum (VD), infrared (IRD), low-temperature (LTVD) and freeze (FD) on bio-compound retention red cabbage its beneficial health properties. total phenolics content (TPC), flavonoids (TFC), anthocyanin (TAC) glucosinolates (TGC) were determined by spectrophotometry. profiles phenolic acids, amino acids fatty HPLC-UV-DAD, LC-DAD GC-FID, respectively. Antioxidant potential was verified DPPH ORAC assays. antiproliferative activity measured in human gastric cell line (AGS). Anti-inflammatory evaluated phorbol 12-myristate 13-acetate arachidonic acid models. VD showed high values TPC = 11.89 ± 0.28 mg GAE/g d.m.; TFC 11.30 0.9 QE/g TAC 0.265 0.01 Cya3glu/g TGC 51.15 3.31 µmol SE/g d.m. Caffeic acid, ferulic sinapic identified. predominant glutamic γ–linolenic antioxidant dependent methods for both Dried extracts clear anti-inflammatory activity. dehydration process an alternative bio-compounds health-promoting properties cabbage.
Язык: Английский
Процитировано
4
Life, Год журнала: 2024, Номер 14(5), С. 606 - 606
Опубликована: Май 9, 2024
Colorectal cancer (CRC) is a heterogenous pathology with high incidence and mortality rates globally, but it also preventable so finding the most promising candidates (natural compounds or repurposed drugs) to be chemopreventive alternatives has become topic of interest in recent years. The present work aims elucidate potential effects combination between genistein (GEN), an isoflavone natural origin, aspirin (ASA) CRC prevention/treatment by performing vitro evaluation human colorectal cells (HCT-116) ovo analysis using chick embryo chorioallantoic membrane (CAM) model. Cell viability was verified MTT (migratory scratch) assay, expressions MMP-2 MMP-9 were analyzed RT-qPCR. Our results indicated dose-dependent cytotoxic effect ASA (2.5 mM) + GEN (10–75 µM) characterized reduced cell morphological changes (actin skeleton reorganization nuclei deterioration), inhibition HCT-116 cells’ migratory down-regulating mRNA expressions, antiangiogenic modifying vascular network. These raise possibility future in-depth investigations regarding chemopreventive/therapeutical ASA+GEN combination.
Язык: Английский
Процитировано
4
Food Bioscience, Год журнала: 2024, Номер 61, С. 104525 - 104525
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
4
Cancer Epidemiology, Год журнала: 2025, Номер 95, С. 102771 - 102771
Опубликована: Фев. 15, 2025
The aim of this study is to evaluate if the alignment with 2020-2025 Dietary Guidelines for Americans (DGA), measured by Healthy Eating Index 2020 (HEI-2020), associated colorectal cancer (CRC) risk in an Italian population. A multicentric case-control was carried out Italy between 1992 and 1996. Cases were 1953 patients (males 58 %, median age = 62 years) admitted major hospitals incident, histologically confirmed CRC. Controls 4154 50 same acute non-neoplastic conditions. Participants' usual diet before enrolment collected using a validated food frequency questionnaire, DGA assessed HEI-2020 score, ranging 0 (no alignment) 100 (complete alignment). Odds ratios (ORs) corresponding 95 % confidence intervals (CIs) estimated multiple logistic regression models including terms selected socioeconomic, lifestyle factors, potential confounders. score ranged from 29.4 97.0. Subjects highest tertile scores had lower CRC compared those lowest (OR: 0.69, CI 0.60-0.80). Similar estimates found colon 0.70, 0.59 - 0.83) rectal 0.56-0.85). findings also consistent across strata different covariates. Alignment inversely
Язык: Английский
Процитировано
0
American Journal of Clinical Nutrition, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Апрель 8, 2025
Despite an apparent increase in early-onset colorectal cancer (CRC) Saudi Arabia, with the majority of patients being diagnosed at advanced disease stage, no previous assessment knowledge, attitudes, and practices (KAP) toward its dietary lifestyle-related risk factors has been reported. The aim this study was to investigate KAP levels respect these for CRC examine possible associations between studied variables among population. This cross-sectional involved 1,040 participants aged 18 years or older. Data were collected by convenience sampling via a self-administered online questionnaire Arabia June December 2023. A (77.8%) displayed low knowledge about CRC, while only 22.2% possessed high knowledge. Similarly, 78.6% exhibited negative attitudes factors, just 21.4% having positive attitudes. Furthermore, 75.0% reported engaging poor practices, leaving 25.0% demonstrating good related factors. findings indicate insufficient highlighting urgent need nationwide initiatives programs promote improved reduce effect contributing CRC.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2024, Номер 13(8), С. 663 - 663
Опубликована: Апрель 9, 2024
Prediabetes and colorectal cancer (CRC) represent compelling health burdens responsible for high mortality morbidity rates, sharing several modifiable risk factors. It has been hypothesized that metabolic abnormalities linking prediabetes CRC are hyperglycemia, hyperinsulinemia, adipokines imbalance. The chronic stimulation related to these signatures can favor onset development, as well negatively influence prognosis. To date, the growing burden of generated a global interest in defining their epidemiological molecular relationships. Therefore, deeper knowledge impairment determinants is identify pathological mechanisms promoting CRC. In this scenario, review aims provide comprehensive overview on alterations an recent preventive therapeutic approaches both diseases, focusing role state pivotal contributor consider development future strategies.
Язык: Английский
Процитировано
3
Phytotherapy Research, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
ABSTRACT Our bodies are constantly exposed to or producing free radicals nearly on a daily basis. These highly reactive molecules generated through variety of internal and external processes pathways within the body. If these not neutralized by antioxidants, they can lead state oxidative stress, which has been linked wide range severe debilitating disorders affecting various systems in human This involves neurodegenerative diseases, diabetes, atherosclerosis, fatty liver, inflammation, aging. Thankfully, body is armed with repertoire powerful antioxidants different natures modes action. The recent decades witnessed publication enormous papers proving antioxidant activity novel synthesized compound, plant extract, purified drug vitro, vivo, even beings. However, efficacy therapies clinical trials, including selenium, vitamin C, E, A, notably inconsistent. inconsistency be primarily ascribed factors related nature radical generation, purpose specific type therapy employed, intricate stress connected network, among others. Collectively, will explored this review article decipher observed shortcomings application settings.
Язык: Английский
Процитировано
2
Foods, Год журнала: 2023, Номер 12(20), С. 3866 - 3866
Опубликована: Окт. 22, 2023
Influenza is an acute respiratory illness caused by the influenza virus, in response to which vaccines and antiviral drugs are administered. In recent years, effects of plants foods have garnered attention. This review first summarize therapeutic properties wild watermelon (Citrullus lanatus var. citroides) against from a phytochemical viewpoint. Wild plant with significant potential as candidate strategies, when focused on its multiple anti-influenza functionalities. juice inhibits viral growth, entry, replication. Hence, we highlight possibility utilizing for prevention treatment stronger activity. Phytochemicals phytoestrogen (polyphenol, flavonoids, prenylated compounds) contribute this activity inhibit various stages replication, depending molecular structure. closely related original species contain many natural compounds such phytochemicals, exhibit growth inhibitory effects. These products provide useful information future strategies.
Язык: Английский
Процитировано
4