Gut Microbiota Interacts with Dietary Habits in Screenings for Early Detection of Colorectal Cancer DOI Open Access

Ana Vega‐Rojas,

Carmen Haro, Helena Molina‐Abril

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 84 - 84

Published: Dec. 28, 2024

Background/Objectives: Gut microbiota interacts with nutrients, which may be relevant to assigning a microbial signature colorectal cancer (CRC). We aim evaluate the potential of gut combined dietary habits in early detection pathological findings related CRC course screening program. Methodology: The colonoscopy performed on 152 subjects positive for fecal occult blood test showed that 6 had adenocarcinoma, 123 polyps, and 23 no findings. was analyzed by 16S metagenomic. Caret package used build classification models R. Results: Random forest (RF) classifier were alone or as biomarker discern between individuals CRC-related lesions (polyps adenocarcinoma) versus without RF yielded an area under curve 0.790 using data, 0.710 0.804 model including data. abundance Suterella, Oscillospirales, Proteobacteria, Burkholderiales highly discriminant groups, together consumption fruit vegetables carbonated and/or sweetened beverages. Conclusions: Our results suggest interaction is when marker CRC. Moreover, information about seem important improving programs

Language: Английский

Healthy Eating Index (HEI-2020) score and colorectal cancer risk DOI Creative Commons
Arianna Natale, Dariush Khaleghi Hashemian, Jerry Polesel

et al.

Cancer Epidemiology, Journal Year: 2025, Volume and Issue: 95, P. 102771 - 102771

Published: Feb. 15, 2025

The aim of this study is to evaluate if the alignment with 2020-2025 Dietary Guidelines for Americans (DGA), measured by Healthy Eating Index 2020 (HEI-2020), associated colorectal cancer (CRC) risk in an Italian population. A multicentric case-control was carried out Italy between 1992 and 1996. Cases were 1953 patients (males 58 %, median age = 62 years) admitted major hospitals incident, histologically confirmed CRC. Controls 4154 50 same acute non-neoplastic conditions. Participants' usual diet before enrolment collected using a validated food frequency questionnaire, DGA assessed HEI-2020 score, ranging 0 (no alignment) 100 (complete alignment). Odds ratios (ORs) corresponding 95 % confidence intervals (CIs) estimated multiple logistic regression models including terms selected socioeconomic, lifestyle factors, potential confounders. score ranged from 29.4 97.0. Subjects highest tertile scores had lower CRC compared those lowest (OR: 0.69, CI 0.60-0.80). Similar estimates found colon 0.70, 0.59 - 0.83) rectal 0.56-0.85). findings also consistent across strata different covariates. Alignment inversely

Language: Английский

Citations

1
Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review DOI Creative Commons

Amira Atta,

Maha M. Salem, Karim Samy El-Said

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Jan. 16, 2024

Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration worsening symptoms. Adenosine deaminase (ADA), enzyme in purine metabolism, influences adenosine levels inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases hypoxic inflammatory conditions. Lymphocytes with play a role RA. lymphocytic activity has immune-regulatory effect. Synovial fluid of are closely associated the disease’s systemic activity, making it useful parameter for evaluating Flavonoids, such as quercetin (QUE), natural substances that can inhibit activity. QUE demonstrates effects restores T-cell homeostasis, promising candidate therapy. In this review, we will explore suppressing reducing produced inflammation RA, including preclinical investigations clinical trials. Graphical

Language: Английский

Citations

7
Health-Promoting Properties of Processed Red Cabbage (Brassica oleracea var. capitata f. rubra): Effects of Drying Methods on Bio-Compound Retention DOI Creative Commons

Nicol Mejías,

Antonio Vega‐Gálvez, Luis S. Gómez‐Pérez

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 830 - 830

Published: March 8, 2024

The aim of this work is to describe the effect convective drying (CD), vacuum (VD), infrared (IRD), low-temperature (LTVD) and freeze (FD) on bio-compound retention red cabbage its beneficial health properties. total phenolics content (TPC), flavonoids (TFC), anthocyanin (TAC) glucosinolates (TGC) were determined by spectrophotometry. profiles phenolic acids, amino acids fatty HPLC-UV-DAD, LC-DAD GC-FID, respectively. Antioxidant potential was verified DPPH ORAC assays. antiproliferative activity measured in human gastric cell line (AGS). Anti-inflammatory evaluated phorbol 12-myristate 13-acetate arachidonic acid models. VD showed high values TPC = 11.89 ± 0.28 mg GAE/g d.m.; TFC 11.30 0.9 QE/g TAC 0.265 0.01 Cya3glu/g TGC 51.15 3.31 µmol SE/g d.m. Caffeic acid, ferulic sinapic identified. predominant glutamic γ–linolenic antioxidant dependent methods for both Dried extracts clear anti-inflammatory activity. dehydration process an alternative bio-compounds health-promoting properties cabbage.

Language: Английский

Citations

5
Genistein–Aspirin Combination Exerts Cytotoxic and Anti-Migratory Effects in Human Colorectal Cancer Cells DOI Creative Commons

Claudia Iftode,

Stela Iurciuc, Iasmina Marcovici

et al.

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 606 - 606

Published: May 9, 2024

Colorectal cancer (CRC) is a heterogenous pathology with high incidence and mortality rates globally, but it also preventable so finding the most promising candidates (natural compounds or repurposed drugs) to be chemopreventive alternatives has become topic of interest in recent years. The present work aims elucidate potential effects combination between genistein (GEN), an isoflavone natural origin, aspirin (ASA) CRC prevention/treatment by performing vitro evaluation human colorectal cells (HCT-116) ovo analysis using chick embryo chorioallantoic membrane (CAM) model. Cell viability was verified MTT (migratory scratch) assay, expressions MMP-2 MMP-9 were analyzed RT-qPCR. Our results indicated dose-dependent cytotoxic effect ASA (2.5 mM) + GEN (10–75 µM) characterized reduced cell morphological changes (actin skeleton reorganization nuclei deterioration), inhibition HCT-116 cells’ migratory down-regulating mRNA expressions, antiangiogenic modifying vascular network. These raise possibility future in-depth investigations regarding chemopreventive/therapeutical ASA+GEN combination.

Language: Английский

Citations

5
Metabolic Alteration Bridging the Prediabetic State and Colorectal Cancer DOI Creative Commons
Antonino Colloca,

Isabella Donisi,

Camilla Anastasio

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 663 - 663

Published: April 9, 2024

Prediabetes and colorectal cancer (CRC) represent compelling health burdens responsible for high mortality morbidity rates, sharing several modifiable risk factors. It has been hypothesized that metabolic abnormalities linking prediabetes CRC are hyperglycemia, hyperinsulinemia, adipokines imbalance. The chronic stimulation related to these signatures can favor onset development, as well negatively influence prognosis. To date, the growing burden of generated a global interest in defining their epidemiological molecular relationships. Therefore, deeper knowledge impairment determinants is identify pathological mechanisms promoting CRC. In this scenario, review aims provide comprehensive overview on alterations an recent preventive therapeutic approaches both diseases, focusing role state pivotal contributor consider development future strategies.

Language: Английский

Citations

4
Exploring the diverse biological activities of Garcinia cowa: Implications for future cancer chemotherapy and beyond DOI
Asad Ur Rahman, Pharkphoom Panichayupakaranant

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104525 - 104525

Published: June 6, 2024

Language: Английский

Citations

4
EAT-Lancet Diet Pattern, genetic risk, and risk of colorectal cancer: a prospective study from the UK Biobank DOI
Fulan Hu, Jia‐Cheng Liu, Li D

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Knowledge, attitudes, and practices toward colorectal cancer lifestyle risk factors among adults in Saudi Arabia DOI Creative Commons

Areej Alkhaldy

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

Despite an apparent increase in early-onset colorectal cancer (CRC) Saudi Arabia, with the majority of patients being diagnosed at advanced disease stage, no previous assessment knowledge, attitudes, and practices (KAP) toward its dietary lifestyle-related risk factors has been reported. The aim this study was to investigate KAP levels respect these for CRC examine possible associations between studied variables among population. This cross-sectional involved 1,040 participants aged 18 years or older. Data were collected by convenience sampling via a self-administered online questionnaire Arabia June December 2023. A (77.8%) displayed low knowledge about CRC, while only 22.2% possessed high knowledge. Similarly, 78.6% exhibited negative attitudes factors, just 21.4% having positive attitudes. Furthermore, 75.0% reported engaging poor practices, leaving 25.0% demonstrating good related factors. findings indicate insufficient highlighting urgent need nationwide initiatives programs promote improved reduce effect contributing CRC.

Language: Английский

Citations

0
Limitations and Challenges of Antioxidant Therapy DOI
Haitham Al‐Madhagi,

Anwar Masoud

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

ABSTRACT Our bodies are constantly exposed to or producing free radicals nearly on a daily basis. These highly reactive molecules generated through variety of internal and external processes pathways within the body. If these not neutralized by antioxidants, they can lead state oxidative stress, which has been linked wide range severe debilitating disorders affecting various systems in human This involves neurodegenerative diseases, diabetes, atherosclerosis, fatty liver, inflammation, aging. Thankfully, body is armed with repertoire powerful antioxidants different natures modes action. The recent decades witnessed publication enormous papers proving antioxidant activity novel synthesized compound, plant extract, purified drug vitro, vivo, even beings. However, efficacy therapies clinical trials, including selenium, vitamin C, E, A, notably inconsistent. inconsistency be primarily ascribed factors related nature radical generation, purpose specific type therapy employed, intricate stress connected network, among others. Collectively, will explored this review article decipher observed shortcomings application settings.

Language: Английский

Citations

2
Fermentative Characteristics and Metabolic Profiles of Japanese Apricot Juice Fermented with Lactobacillus acidophilus and Torulaspora delbrueckii DOI Creative Commons

Benjawan Papun,

Pairote Wongputtisin, Apinun Kanpiengjai

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3455 - 3455

Published: Oct. 29, 2024

Functional fermented fruit juices produced using a combination of non-Saccharomyces yeast and lactic acid bacteria (LAB) are relatively unexplored. The effects three inoculation protocols, single with Lactobacillus acidophilus (La), Torulaspora delbrueckii (Td), co-culture both La + Td, on the physicochemical, microbiological, sensory properties, metabolic profile JA after 24 h at 30 °C were investigated. Uninoculated (UI) Japanese apricot (JA) juice was used as control. results show significant increases in color intensity fermented-JA juices, whereas an enhancement total phenolic contents is observed JA-juices acquired through use for inoculations. colony counts LAB inoculated increased by approximately 2.0 1.7 log CFU/mL h, respectively. antibacterial activity against four pathogenic detected. All exhibited antimicrobial tested strains, strong properties La-fermented being recorded Bacillus cereus lowest MIC 124 µL/mL. Additionally, Td-fermented UI-JA demonstrated comparable anticancer HT-29 cells IC50 values 823.37 754.87 µg/mL, Furthermore, 995 compounds identified differential fermentation metabolites non-targeted metabolome analysis across different groups. These findings illustrate potential Td to develop functional juices.

Language: Английский

Citations

2