Computational and Structural Biotechnology Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
The
strategic
objective
of
the
Safe
and
sustainable
by
design
next
generation
chemicals
materials
(SSbD4CheM)
project
is
to
develop
screening
testing
strategies
for
a
variety
substances
ensure
safer
more
products
in
line
with
Sustainable
Products
Initiative.
SSbD4CHeM
focusing
on
chemical
safety
using
new
approach
methods,
including
vitro
studies
without
animal
models
silico
tools.
Additionally,
it
integrates
environmental
sustainability
implementation
Design
(SSbD)
framework
risk
assessment
ex-ante
life
cycle
assessment.
New
methods
along
chemical,
material
product
cycles
will
be
developed,
validated,
applied
three
case
studies,
biobased
self-cleaning,
water
repellent,
antimicrobial
treatments
textiles,
nanocellulose
as
an
additive
cosmetics,
microcellulose
composites
automotive
industry.
By
employing
multidisciplinary
strategy,
addresses
key
challenges
innovation,
ensuring
regulatory
compliance
while
reducing
hazards
human
health.
accelerate
development
next-generation
materials,
promoting
industry
progress,
improved
consumer
safety.
Ultimately,
SSbD4CheM
aims
establish
benchmark
that
conform
goals.
Experimental and Therapeutic Medicine,
Год журнала:
2021,
Номер
22(5)
Опубликована: Сен. 17, 2021
Biocompatibility
is
one
of
the
mandatory
requirements
for
clinical
use
biomaterials
in
orthopedics.
It
refers
to
ability
a
biomaterial
perform
its
function
without
eliciting
toxic
or
injurious
effects
on
biological
systems
but
producing
an
appropriate
host
response
specific
case.
Today,
biocompatibility
concept
includes
not
only
bio‑inertia,
also
biofunctionality
and
biostability.
High
functional
properties
are
highly
desirable
new
biomaterials.
The
chemical,
mechanical,
structural
biomaterials,
their
interaction
with
environment
even
methodology
assessment
can
influence
biocompatibility.
evaluation
broad
spectrum
in
vitro
vivo
tests
related
cytocompatibility,
genotoxicity,
sensitization,
irritation,
acute
chronic
toxicity,
hemocompatibility,
reproductive
developmental
toxicitity,
carcinogenicity,
implantation
degradation
as
specified
different
international
standards.
A
brief
review
main
assays
used
testing
orthopedic
presented.
In
addition,
issues
overviewed.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Molecules,
Год журнала:
2021,
Номер
26(16), С. 4710 - 4710
Опубликована: Авг. 4, 2021
The
potential
of
nanomaterials
use
is
huge,
especially
in
fields
such
as
medicine
or
industry.
Due
to
widespread
nanomaterials,
their
cytotoxicity
and
involvement
cellular
pathways
ought
be
evaluated
detail.
Nanomaterials
can
induce
the
production
a
number
substances
cells,
including
reactive
oxygen
species
(ROS),
participating
physiological
pathological
processes.
These
highly
include:
superoxide,
singlet
oxygen,
hydroxyl
radical,
hydrogen
peroxide.
For
overall
assessment,
there
are
fluorescent
probes
particular
that
very
specific
selective
for
given
ROS.
In
addition,
due
ROS
signaling
pathways,
understanding
principle
induced
by
important.
defense,
cells
have
reparative
antioxidant
mechanisms.
One
most
potent
antioxidants
tripeptide
glutathione.
Thus,
glutathione
depletion
characteristic
manifestation
harmful
effects
caused
prooxidative-acting
cells.
these
reasons,
here
we
would
like
provide
review
on
current
knowledge
ROS-mediated
nanotoxicity
manifesting
depletion,
an
overview
approaches
detection
levels
Nanomaterials,
Год журнала:
2022,
Номер
12(8), С. 1346 - 1346
Опубликована: Апрель 14, 2022
The
growing
development
and
applications
of
nanomaterials
lead
to
an
increasing
release
these
materials
in
the
environment.
adverse
effects
they
may
elicit
on
ecosystems
or
human
health
are
not
always
fully
characterized.
Such
potential
toxicity
must
be
carefully
assessed
with
underlying
mechanisms
elucidated.
To
that
purpose,
different
approaches
can
used.
First,
experimental
toxicology
consisting
conducting
vitro
vivo
experiments
(including
clinical
studies)
used
evaluate
nanomaterial
hazard.
It
rely
variable
models
(more
less
complex),
allowing
investigation
biological
endpoints.
respective
advantages
limitations
discussed
as
well
some
issues
associated
nanotoxicology.
Perspectives
future
developments
field
also
proposed.
Second,
computational
nanotoxicology,
i.e.,
silico
approaches,
predict
toxicity.
In
this
context,
we
describe
general
principles,
advantages,
especially
quantitative
structure–activity
relationship
(QSAR)
grouping/read-across
approaches.
aim
review
is
provide
overview
based
examples
highlight
their
complementarity.
Archives of Toxicology,
Год журнала:
2022,
Номер
96(7), С. 1935 - 1950
Опубликована: Май 3, 2022
Abstract
Alternative
methods
to
animal
use
in
toxicology
are
evolving
with
new
advanced
tools
and
multilevel
approaches,
answer
from
one
side
3Rs
requirements,
on
the
other
offering
relevant
valid
tests
for
drugs
chemicals,
considering
also
their
combination
test
strategies,
a
proper
risk
assessment.
While
stand-alone
methods,
have
demonstrated
be
applicable
some
specific
toxicological
predictions
limitations,
strategy
application
of
New
Approach
Methods
(NAM),
solve
complex
endpoints
is
addressed
by
Integrated
Approaches
Testing
Assessment
(IATA),
aka
Strategies
(ITS)
or
Defined
(DA).
The
central
challenge
evidence
integration
shared
needs
assessment
systematic
reviews
an
evidence-based
Toxicology.
Increasingly,
machine
learning
(aka
Artificial
Intelligence,
AI)
lends
itself
integrate
diverse
streams.
In
this
article,
we
give
overview
state
art
alternative
IATA
regulatory
various
hazards,
outlining
future
orientation
perspectives.
We
call
leveraging
synergies
integrated
approaches
vivo,
vitro
silico
as
true
vivitrosi.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis,
Год журнала:
2022,
Номер
881, С. 503520 - 503520
Опубликована: Июнь 23, 2022
The
comet
assay
is
used
to
measure
DNA
damage
induced
by
chemical
and
physical
agents.
High
concentrations
of
test
agents
may
cause
cytotoxicity
or
cell
death,
which
give
rise
false
positive
results
in
the
assay.
Systematic
studies
on
genotoxins
cytotoxins
(i.e.
non-genotoxic
poisons)
have
attempted
establish
a
threshold
death
measured
could
be
regarded
as
result.
Thresholds
cytotoxicity/cell
range
from
20%
50%
various
publications.
Curiously,
survey
latest
literature
culture
suggests
that
one-third
publications
did
not
assess
death.
We
recommend
it
should
mandatory
include
at
least
one
type
cytotoxicity,
proliferation
results.
A
combination
(or
death)
colony
forming
efficiency
assay)
preferable
actively
proliferating
cells
because
covers
more
mechanisms
action.
Applying
general
all
types
applicable;
however,
25%
compared
concurrent
negative
control
seems
good
starting
value
avoid
Further
research
needed
distinguish
between
true
potentially
genotoxic
effects
detected
Nanomaterials,
Год журнала:
2023,
Номер
13(3), С. 472 - 472
Опубликована: Янв. 24, 2023
The
Safe-by-Design
(SbD)
concept
aims
to
facilitate
the
development
of
safer
materials/products,
production,
and
use
end-of-life
by
performing
timely
SbD
interventions
reduce
hazard,
exposure,
or
both.
Early
hazard
screening
is
a
crucial
first
step
in
this
process.
In
review,
for
time,
commonly
used
vitro
assays
are
evaluated
their
suitability
testing
nanomaterials
(NMs).
goal
identifying
warnings
early
stages
innovation.
For
purpose,
should
be
simple,
cost-effective,
predictive,
robust,
compatible.
several
toxicological
endpoints,
there
indications
that
able
predict
warnings.
addition
evaluation
assays,
review
provides
insights
into
effects
choice
cell
type,
exposure
dispersion
protocol,
(in)accurate
determination
dose
delivered
cells
on
predictivity.
Furthermore,
compatibility
with
challenging
advanced
materials
NMs
released
from
nano-enabled
products
(NEPs)
during
lifecycle
assessed,
as
these
aspects
testing.
To
conclude,
complex
joint
efforts
between
innovators,
scientists,
regulators
needed
further
improve
