Recent advances in drug delivery systems for osteosarcoma therapy and bone regeneration

Communications Materials, Год журнала: 2024, Номер 5(1)

Опубликована: Авг. 27, 2024

Osteosarcoma, the predominant bone malignancy, poses significant challenges due to its high metastatic potential and recurrence rates. Accounting for a substantial percentage of malignant tumors, osteosarcoma particularly affects children adolescents. Despite standard treatment combining surgery multi-drug chemotherapy, systemic drug administration presents limitations, leading compromised patient quality life severe side effects. New strategies are needed address these enhance efficacy while minimizing toxicity. Here, we explore delivery platforms in context treatment. We delve into both local approaches, highlighting recent advances controlled release triggered by various stimuli, modifications targeted delivery, co-delivery chemotherapeutics using nano-platforms. Additionally, discuss innovations methods, including implantable nanoparticles, injectable hydrogels, scaffolds. advancements, limitations persist, emphasizing need continued research. conclude offering perspectives on multifunctional scaffolds revolutionizing thereby paving way improved survival enhanced life. Drug combatting osteosarcoma, which accounts large proportion tumors. This Review highlights progress nanoparticle-based such as scaffolds, addressing ongoing future research needs.

Язык: Английский

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Nano-scale drug delivery systems for carboplatin: A comprehensive review

OpenNano, Год журнала: 2023, Номер 13, С. 100175 - 100175

Опубликована: Июль 25, 2023

Язык: Английский

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Green Synthesis of pH-Sensitive Carboxymethyl Cellulose/Agarose/Carbon Quantum Dots Nanocarriers for Quercetin Delivery to A549 Lung Cancer Using an Emulsification Method

BioNanoScience, Год журнала: 2024, Номер unknown

Опубликована: Июнь 8, 2024

Язык: Английский

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Enhanced anticancer activity of silver doped zinc oxide magnetic nanocarrier loaded with sorafenib for hepatocellular carcinoma treatment

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 5, 2024

Drug delivery is the process or method of delivering a pharmacological product to have therapeutic effects on humans animals. The use nanoparticles deliver medications cells driving present surge in interest improving human health. Green nanodrug methods are based chemical processes that acceptable for environment natural biomaterials such as plant extracts and microorganisms. In this study, zinc oxide-superparamagnetic iron oxide-silver nanocomposite was synthesized via green synthesis using Fusarium oxysporum fungi mycelia then loaded with sorafenib drug. nanocomposites were characterized by UV-visibile spectroscopy, FTIR, TEM SEM techniques. Sorafenib cancer treatment also known its brand name, Nexavar. only systemic medication available world treat hepatocellular carcinoma. Sorafenib, like many other chemotherapeutics, has side restrict effectiveness, including toxicity, nausea, mucositis, hypertension, alopecia, hand-foot skin reaction. our 40 male albino rats given single dose diethyl nitrosamine (DEN) 60 mg/kg b.wt., followed carbon tetrachloride 2 ml/kg b.wt. twice week one month. aim study nanocarrier enhancement anticancer effect.

Язык: Английский

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Advancements in Stimulus-Responsive Co-Delivery Nanocarriers for Enhanced Cancer Immunotherapy

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 3387 - 3404

Опубликована: Апрель 1, 2024

Abstract: Cancer immunotherapy has emerged as a novel therapeutic approach against tumors, with immune checkpoint inhibitors (ICIs) making significant clinical practice. The traditional ICIs, PD-1 and PD-L1, augment the cytotoxic function of T cells through inhibition tumor evasion pathways, ultimately leading to initiation an antitumor response. However, implementation ICIs encounters obstacles stemming from existence immunosuppressive microenvironment inadequate infiltration CD8 + cells. Considerable attention been directed towards advancing immunogenic cell death (ICD) potential solution counteract microenvironment. This holds promise in transforming "cold" tumors into "hot" that exhibit responsiveness antitumor. By combining ICD synergistic response can be achieved. combination inducers PD-1/PD-L1 is hindered by issues such poor targeting uncontrolled drug release. An advantageous presented stimulus-responsive nanocarrier integrating physicochemical properties inhibitors, facilitating precise delivery specific tissues for optimal therapy. Moreover, these nanocarriers leverage distinct features accomplish controlled release regulate kinetics delivery. article aims investigate advancement co-delivery utilizing inhibitors. Special focus dedicated exploring advantages recent advancements this system enabling inducers. molecular mechanisms are concisely summarized. In conclusion, we examine research prospects challenges could greatly enhance immunotherapeutic approaches cancer treatment. Keywords: therapy, death, co-delivery, immune-checkpoint

Язык: Английский

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Magnetically Active Bicontinuous Polymer Structures for Multiple Controlled Drug Delivery

Macromolecular Bioscience, Год журнала: 2024, Номер unknown

Опубликована: Май 11, 2024

Abstract The targeted delivery of drugs using wireless navigable magnetic robots allows the drug molecules to be controlled non only in time but also space, improving medical outcomes. main disadvantages behind their use lies low amount that can transported and single nature loaded (hydrophilic or hydrophobic). These considerations limit co‐delivery systems, now recognized very promising for many different pathologies. A bijel‐like structure is developed load release types In this work, ε‐caprolactone explored, which polymerize, forming hydrophobic domains (oil phase). After mixing with iron oxide nanoparticles (NPs), water dispersion creates a biphasic porous without phase separation. resulting device shows good performance both actuation as system.

Язык: Английский

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Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 741 - 770

Опубликована: Янв. 1, 2025

Different types of cancers affect the gastrointestinal tract (GIT), starting from oral cavity and extending to colon. In general, most current research focuses on systemic delivery therapeutic agents, which leads undesired side effects a limited enhancement in outcomes. As result, localized within (GI) is favorable overcoming these limitations. However, via administration faces many challenges related complex structure GIT (varied pH levels transit times) as well harsh environment tumor cells (hypoxia, efflux pumps, acidity). To overcome obstacles, nano-drug systems (NDDs) have been designed proved their potential by exploiting favor offering specific desired target. The review begins with an overview different GI impact globally. Then, it discusses treatment approaches corresponding Additionally, associated drug for are summarized. Finally, detail recent diagnostic applications NDDs that conducted oral, esophageal, gastric, colon, liver cancers, aiming offer valuable insights into future state utilizing local cancers.

Язык: Английский

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Role of liposomes in chemoimmunotherapy of Breast cancer

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 43

Опубликована: Фев. 19, 2025

In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.

Язык: Английский

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An innovative approach to development of new pyrazolylquinolin-2-one hybrids as dual EGFR and BRAFV600E inhibitors

Molecular Diversity, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Novel quinoline-based derivatives 2a-e and 4a-j have been designed synthesized as potential antiproliferative agents. The compounds were screened for their activity against sixty cell lines according to NCI protocol. promising hybrids 4d-g are by MTT assays on three cancer lines: leukemia (MOLT-4), lung (HOP-92), breast (T47D), with IC50 values ranging from 4.982 ± 0.2 36.52 1.46 µM compared Staurosporine, compound 4e being the most effective. Derivatives evaluated inhibitory EGFR BRAFV600E. Compound exhibited highest activities, of 0.055 0.002 μM 0.068 0.003 BRAFV600E, reference drugs erlotinib (IC50 0.06 μM) vemurafenib 0.035 0.001 μM), respectively. Cell cycle analysis HOP-92 manifested that pre-G1 apoptosis signaling took place after treatment. Docking simulations employed analyze modes scores respect results revealed strong affinity both BRAFV600E - 3.226 3.474 kcal/mol,

Язык: Английский

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A novel approach for the co-delivery of 5-fluorouracil and everolimus for breast cancer combination therapy: stimuli-responsive chitosan hydrogel embedded with mesoporous silica nanoparticles

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 31, 2025

Abstract Background Breast cancer remains one of the leading causes death among women globally, with traditional therapies often limited by challenges such as drug resistance and significant side effects. Combination therapies, coupled nanotechnology-based co-delivery systems, offer enhanced efficacy targeting multiple pathways in progression. In this study, we developed an injectable, stimuli-responsive nanosystem using a chitosan hydrogel embedded mesoporous silica nanoparticles for co-administration 5-fluorouracil everolimus. This approach aims to optimize controlled release, enhance synergistic anticancer effect, overcome associated co-loading different therapeutic agents. Methods Various techniques were employed characterize hydrogel. Cell uptake, apoptosis, proliferation 4T1 breast cells evaluated flow cytometry Resazurin assay, respectively. The Balb/C mice model cancer, which received therapeutical nanoplatforms subcutaneously near tumoral region was used examine tumor size lung metastases. Results results revealed that had suitable loading capacity high cellular uptake. release pH-sensitive synergistic. By incorporating into hydrogel, cell rate apoptosis increased significantly, due effects co-delivered drugs. Additionally, combination treatment groups showed reduction metastasis compared monotherapy control groups. Conclusions These findings underscore potential nanocomposite develop novel system outcomes, reduce effects, provide promising new strategy future treatments.

Язык: Английский

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