Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 1127 - 1149

Опубликована: Дек. 26, 2022

Язык: Английский

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Composition of Human Breast Milk Microbiota and Its Role in Children’s Health

Pediatric Gastroenterology Hepatology & Nutrition, Год журнала: 2022, Номер 25(3), С. 194 - 194

Опубликована: Янв. 1, 2022

Human milk contains a number of nutritional and bioactive molecules including microorganisms that constitute the so-called "Human Milk Microbiota (HMM)".Recent studies have shown not only bacterial but also viral, fungal, archaeal components are present in HMM.Previous research has established, "core" microbiome, consisting Firmicutes (i.e., Streptococcus, Staphylococcus), Proteobacteria Serratia, Pseudomonas, Ralstonia, Sphingomonas, Bradyrhizobium), Actinobacteria Propionibacterium, Corynebacterium).This review aims to summarize main characteristics HMM role it plays shaping child's health.We reviewed most recent literature on topic (2019-2021), using PubMed database.The sources origin were identified as retrograde flow entero-mammary pathway.Several factors can influence its composition, such maternal body mass index diet, use antibiotics, time type delivery, mode breastfeeding.The COVID-19 pandemic, by altering mother-infant dyad modifying many our previous habits, emerged new risk factor for modification HMM.HMM is an important contributor gastrointestinal colonization children therefore, fundamental avoid any form perturbation alter microbial equilibrium, especially first 100 days life.Microbial dysbiosis be trigger point development necrotizing enterocolitis, preterm infants, onset chronic diseases, asthma obesity, later life.

Язык: Английский

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Antimicrobial Properties of Colostrum and Milk

Antibiotics, Год журнала: 2024, Номер 13(3), С. 251 - 251

Опубликована: Март 11, 2024

The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed cautious attitude towards chemical preservatives. Colostrum milk are excellent sources antibacterial components that help to strengthen immunity offspring accelerate maturation immune system. It possible study these important defenses colostrum, such as lactoferrin, lysozyme, immunoglobulins, oligosaccharides, etc., biotherapeutic agents for prevention treatment numerous infections caused by microbes. Each has different mechanisms interactions in various places. compound’s action determine where activity appears. activation colostrum compounds can start infant’s mouth during lactation continue gastrointestinal regions. These properties possess potential therapeutic uses. order discover new perspectives methods bacterial infections, additional investigations complexes required.

Язык: Английский

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25 Years of Research in Human Lactation: From Discovery to Translation

Nutrients, Год журнала: 2021, Номер 13(9), С. 3071 - 3071

Опубликована: Авг. 31, 2021

Researchers have recently called for human lactation research to be conceptualized as a biological framework where maternal and infant factors impacting milk, in terms of composition, volume energy content are studied along with relationships growth, development health. This approach allows the evidence-based interventions that more likely support breastfeeding pursuit global goals. Here we summarize seminal findings our programme using systems traversing breast anatomy, milk secretion, physiology removal respect expression, composition intake, gastric emptying, culminating exploration body has allowed translation education, clinical practice. It also sets foundation improved study design future investigations lactation.

Язык: Английский

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Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Май 12, 2022

Exposure to synthetic and natural chemicals is a major environmental risk factor in the etiology of many chronic diseases. Investigating complex co-exposures necessary for holistic assessment exposome-wide association studies. In this work, sensitive liquid chromatography-tandem mass spectrometry approach was developed validated. The assay enables analysis more than 80 highly-diverse xenobiotics urine, serum/plasma, breast milk; with detection limits generally pg-ng mL

Язык: Английский

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Lactobacillus reuteri improves the development and maturation of fecal microbiota in piglets through mother-to-infant microbe and metabolite vertical transmission

Microbiome, Год журнала: 2022, Номер 10(1)

Опубликована: Дек. 2, 2022

Abstract Background The immature neonatal fecal microbiota substantially impacts the development of gut health and greatly increases risk disease. Developing effective strategies to modulate has great significance. Herein, we investigated whether maternal dietary supplementation oral administration Lactobacillus reuteri could effectively promote maturation microbiome in piglets from birth weaning. Results Metagenomic analysis colostrum showed that L. influenced overall composition, decreased abundance phylum Proteobacteria increased species Bifidobacterium choerinum . KEGG pathway revealed enriched lysine biosynthesis glycolysis/gluconeogenesis pathways downregulated bacterial invasion epithelial cells colostrum. In addition, significantly altered metabolite features modules umbilical cord blood serum based on metabolomics. Further, a significant covariation was observed between these differential metabolites Maternal also composition meconium beneficial bacteria (such as Romboutsia , Blautia Butyricicoccus Ruminococcus ), some which were markedly associated with several two groups. Notably, both intake had strong microbial during early life, effects dependent growth stage. Oral promoted diarrhea resistance neonates, while enhanced abilities antioxidants inflammation. Moreover, via methods combination improved performances piglets. Conclusion Overall, our data demonstrated ability newborn by influencing community functional altering key serum. Also, life. Both optimized

Язык: Английский

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Impacts of Consumption of Ultra-Processed Foods on the Maternal-Child Health: A Systematic Review

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Май 13, 2022

Changes in eating patterns have been leading to an increase the consumption of ultra-processed foods (UPF), negatively impacting quality diet and generating risk harm health adult population, however, there is no systematized evidence impact UPF maternal-child health. Thus, this study we aimed evaluated association between outcomes population.Systematic review registered on International Prospective Register Systematic Reviews (PROSPERO) (CRD42021236633), conducted according PRISMA diagram following databases: PubMed, Medline, Scopus, Web Science, Scielo, CAPES thesis dissertation directory. We included original cross-sectional, case-control cohort studies any language. Eligibility criteria were (a) food assessment by NOVA classification, (b) outcome (nutritional or diseases), (c) population (pregnant, lactating women infants/children). All data analyzed extracted a spreadsheet structured two independent reviewers. methodological using Newcastle-Otawa Scale RoB 2.Searches retrieved 7,801 15 contemplated eligibility criteria. Most (n = 8, 53%), had children as their 9, 60%) only one infants women. Panoramically, observed that higher participation children's has associated with different outcomes, such weight gain, adiposity measures, overweight, early weaning, lower quality, metabolic alterations, diseases, plastic originated from packaging. Only did not present high quality.Despite limited literature highest impacted nutrition disease development indicators pregnant, children. Considering expressive these diet, other should be further investigate indicators, especially lactation phase for was most important knowledge gap.[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021236633], identifier [CRD42021236633].

Язык: Английский

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Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2471 - 2471

Опубликована: Янв. 27, 2023

Necrotizing enterocolitis (NEC) is a life-threatening disease that predominantly affects very low birth weight preterm infants. Development of NEC in infants accompanied by high mortality. Surgical treatment can be complicated short bowel syndrome, intestinal failure, parenteral nutrition-associated liver disease, and neurodevelopmental delay. Issues surrounding pathogenesis, prevention, remain unclear. This review summarizes data on prenatal risk factors for NEC, the role pre-eclampsia, intrauterine growth retardation pathogenesis NEC. The hypoxia discussed. Recent microbiome development features metabolome serve as potential biomarkers, are presented. Pseudomonadota phylum known to associated with neonates, other bacteria their metabolites also most promising approaches preventing treating summarized.

Язык: Английский

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Ginger: a representative material of herb-derived exosome-like nanoparticles

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июль 13, 2023

Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactive components, are considered the primary source of natural medicines within plant kingdom. Recently, a number herbaceous sources have been investigated isolation functionality (ELNs). However, they commonly referred as PELNs, distinct pharmacological properties overlooked. In this review, these herb-derived ELNs designated HELNs, novel herbal product that may also exhibit superior activity compared other types PELNs. Among documented ginger-derived (GELNs) most extensively studied. This review employs GELNs an exemplar delineate process extraction purification, together physical biochemical characteristics therapeutic potential. The aim is promote development application future research encouraged uncover additional properties, extending beyond those GELNs.

Язык: Английский

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Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Foods, Год журнала: 2024, Номер 13(6), С. 907 - 907

Опубликована: Март 16, 2024

A strong correlation between the occurrence of various pathological conditions and intestinal dysbiosis is supported by a range evidence. Vice versa, many pathologies have been shown, in turn, to be responsible for alterations gut microbiota, condition that can worsen illness outcomes response therapies. For these reasons, great efforts made, studies are still ongoing, elucidate mechanisms underlying microbiota search pharmacologic or other strategies effectively restore microbiota. In this narrative review, we examined most significant literature on role some milk bioactive compounds, such as oligosaccharides whey proteins, modulating composition action, with aim investigating impact changes mediated molecules human health, their potential use therapeutics treat adjuvate treatment associated pathologies.

Язык: Английский

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