Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Endocrine Reviews, Год журнала: 2021, Номер 43(2), С. 405 - 436

Опубликована: Сен. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Язык: Английский

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Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women

Nutrients, Год журнала: 2025, Номер 17(1), С. 169 - 169

Опубликована: Янв. 2, 2025

Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women. Methods: Random allocation sixty-one participants into four groups: early plus (ETRE-PA, n = 15, 31.8 ± 10.76 years, 89.68 13.40 kg, 33.5 5.53 kg/m2), late (LTRE-PA, 30.60 7.94 94.45 15.36 34.37 7.09 only (LTRE, 27.93 9.79 88.32 10.36 32.71 5.15 kg/m2) control group (CG, 36.25 11.52 89.01 11.68 33.66 6.18 kg/m2). The intervention lasted for 12 weeks all groups. Both ETRE-PA LTRE-PA groups engaged rigorous aerobic resistance-training program. Results: Significant reductions body weight mass index were observed compared to CG LTRE post-intervention (p < 0.0005). Only exhibited significant decrease fat 0.02), low-density lipoprotein cholesterol 0.01), aspartate aminotransferase 0.002). alanine levels 0.004) 0.02) These two latter achieved higher performances 6-min walking test, bench press, 30-s squat, crunch vertical jump 0.0005 both), leg extension 0.02 both) when Conclusion: integration TRE PA leads greater improvements composition, lipid profile, performance, no differences between approaches. This strategy offers promising solution

Язык: Английский

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Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials

Nutrients, Год журнала: 2022, Номер 14(22), С. 4778 - 4778

Опубликована: Ноя. 11, 2022

Time-restricted feeding (TRF) and Ramadan fasting (RF) have been recently associated with several health outcomes. However, it is not yet clear if they are superior to existing treatments in terms of glucose metabolism, insulin action, weight loss. This review aims summarize the current data on effects these regimes body weight, composition, glycemia. An electronic search was conducted PUBMED SCOPUS databases up August 2022. Twenty-four records met inclusion criteria underwent a risk-of-bias assessment. The main outcomes were: (a) TRF may result moderate loss individuals overweight/obesity; when combined caloric restriction, >5% initial (b) 14 h be as effective 16 loss, (c) lead improved sensitivity glycemic responses/variability throughout day overweight/obesity. Concerning RF, only two studies were available thus, conclusions drawn. an nutritional approach for amelioration control more long-term, well-designed needed.

Язык: Английский

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Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice

Cell Metabolism, Год журнала: 2023, Номер 35(7), С. 1179 - 1194.e5

Опубликована: Июль 1, 2023

Язык: Английский

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Intermittent fasting—the future treatment in NASH patients?

Hepatology, Год журнала: 2023, Номер 78(4), С. 1290 - 1305

Опубликована: Апрель 14, 2023

NASH is one of the leading causes chronic liver disease with potential evolving towards end-stage and HCC, even in absence cirrhosis. Apart from becoming an increasingly prevalent indication for transplantation cirrhotic HCC patients, its burden on healthcare system also exerted by increased number noncirrhotic patients. Intermittent fasting has recently gained more interest scientific community as a possible treatment approach different components metabolic syndrome. Basic science clinical studies have shown that apart inducing body weight loss, improving cardiometabolic parameters, namely blood pressure, cholesterol, triglyceride levels; insulin glucose metabolism; intermittent can reduce inflammatory markers, endoplasmic reticulum stress, oxidative autophagy, endothelial dysfunction, well modulate gut microbiota. This review aims to further explore main pathogenetic drivers which act upon improve prognosis disease, summarize current evidence.

Язык: Английский

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Randomized Controlled Feasibility Trial of Late 8-Hour Time-Restricted Eating for Adolescents With Type 2 Diabetes

Journal of the Academy of Nutrition and Dietetics, Год журнала: 2024, Номер 124(8), С. 1014 - 1028

Опубликована: Авг. 1, 2024

Язык: Английский

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Time-Limited Eating and Continuous Glucose Monitoring in Adolescents with Obesity: A Pilot Study

Nutrients, Год журнала: 2021, Номер 13(11), С. 3697 - 3697

Опубликована: Окт. 21, 2021

Due to its simplicity, time-limited eating (TLE) may represent a more feasible approach for treating adolescents with obesity compared other caloric restriction regimens. This pilot study examines the feasibility and safety of TLE combined continuous glucose monitoring (CGM) in adolescents. Fifty BMI ≥95th percentile were recruited complete 12-week study. All received standard nutritional counseling, wore CGM daily, randomized to: (1) Prolonged window: 12 h eating/12 fasting + blinded CGM; (2) (8 eating/16 fasting, 5 days per week) (3) real-time feedback. Recruitment, retention, adherence recorded as indicators feasibility. Weight loss, dietary intake, physical activity, behaviors, quality life over course intervention explored secondary outcomes. Forty-five participants completed (16.4 ± 1.3 years, 64% female, 49% Hispanic, 75% public insurance). There was high prescribed windows (TLE 5.2 d/wk [SD 1.1]; control 6.1 1.4]) daily wear (5.85 4.8]). Most (90%) assigned reported that limiting their window wearing without negative impact on functioning or adverse events. no between-group difference terms weight energy life, behaviors. appears safe among obesity. Further investigation larger samples, longer duration follow-up assessments are needed.

Язык: Английский

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One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike

Journal of Biological Rhythms, Год журнала: 2024, Номер 39(3), С. 237 - 269

Опубликована: Фев. 20, 2024

Circadian biology's impact on human physical health and its role in disease development progression is widely recognized. The forefront of circadian rhythm research now focuses translational applications to clinical medicine, aiming enhance diagnosis, prognosis, treatment responses. However, the field medicine has predominantly concentrated healthcare, neglecting potential for transformative veterinary thereby overlooking opportunities improve non-human animal welfare. This review consists three main sections. first section into current industry practices agricultural animals, with a particular emphasis horses, broiler chickens, laying hens. second delves small care, primarily focusing our companion namely dogs cats. final explores emerging frontiers encompassing aquaculture, hospital welfare concludes integration One Health principles. In summary, represents highly promising that holds significantly care overall all extending beyond healthcare.

Язык: Английский

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Assessing temporal eating pattern in free living humans through the myCircadianClock app

International Journal of Obesity, Год журнала: 2022, Номер 46(4), С. 696 - 706

Опубликована: Янв. 8, 2022

Язык: Английский

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Obesity, cancer risk, and time-restricted eating

Cancer and Metastasis Reviews, Год журнала: 2022, Номер 41(3), С. 697 - 717

Опубликована: Авг. 19, 2022

Obesity and the associated metabolic syndrome is considered a pandemic whose prevalence steadily increasing in many countries worldwide. It complex, dynamic, multifactorial disorder that presages development of several metabolic, cardiovascular, neurodegenerative diseases, increases risk cancer. In patients with newly diagnosed cancer, obesity worsens prognosis, recurrence decreasing survival. The multiple negative effects on cancer outcomes are substantial, great clinical importance. Strategies for weight control have potential utility both prevention efforts enhancing outcomes. Presently, time-restricted eating (TRE) popular dietary intervention involves limiting consumption calories to specific window time without any proscribed caloric restriction or alteration composition. As such, TRE sustainable long-term behavioral modification, when compared other interventions, has shown health benefits animals humans. preliminary data regarding feeding growth animal models promising but studies humans lacking. Interestingly, short-term randomized trials favorable reduce factors; however, yet investigate reductions incidence general population. Few been conducted populations, number underway examine effect biology recurrence. Given simplicity, feasibility, improvements elicited by obese men women, may be useful survivors; implementation setting will require greater in-depth investigation.

Язык: Английский

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