Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

Nutrients, Год журнала: 2021, Номер 13(11), С. 4080 - 4080

Опубликована: Ноя. 15, 2021

Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for impairment and dementia is advanced age followed by other determinants such genetic, socioeconomic, environmental factors, including nutrition physical activity. In the next decades, a rise in cases expected due largely aging of world population. There no hitherto effective pharmaceutical therapies treat age-associated dementia, which underscores crucial role prevention. A relationship among diet, activity, lifestyle with function has been intensively studied mounting evidence supporting these development decline chief cause disability globally. Several dietary patterns, foods, nutrients have investigated this regard, some encouraging disappointing results. This review presents current effects components, supplements, sleep social engagement on prevention or delay onset age-related dementia.

Язык: Английский

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Mediterranean diet in the management and prevention of obesity

Experimental Gerontology, Год журнала: 2023, Номер 174, С. 112121 - 112121

Опубликована: Фев. 17, 2023

The current pandemic of obesity represents a major global public health problem, mainly due to its association with chronic non-communicable disabling conditions and increased mortality. Population aging increases the chances diseases allowing longer exposure risk factors for these conditions. Obesity is factor contributing pathological aging. Numerous epidemiological studies have shown that death cardiovascular disease cancer progressively as overweight rise. Nutrition research now focused on effects combinations foods in dietary patterns instead those single nutrients or foods. model largest body evidence benefit traditionally followed by inhabitants some Mediterranean countries. There confirming inverse adhering diet obesity. Four meta-analyses randomized controlled trials, including up 16 greater reduction weight BMI MedDiet compared other diets, while meta-analysis 7 prospective cohort studies, found reduced becoming obese gaining over time associated higher adherence MedDiet. This narrative review examines reporting associations overweight/obesity age-associated related

Язык: Английский

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Healthy Aging and Dietary Patterns

Nutrients, Год журнала: 2022, Номер 14(4), С. 889 - 889

Опубликована: Фев. 20, 2022

A number of factors contribute to the complex process aging, which finally define whether someone will or not develop age-associated chronic diseases in late life. These determinants comprise genetic susceptibility as well various behavioral, environmental, and dietary factors, all have been shown influence specific pathways regulating aging extension life, makes longevity a multidimensional phenomenon. Although "miraculous elixir" "nutrition pill" are plausible, researchers agree on notion that nutritional major impact risk non-communicable mortality. In recent years nutrition research relation health outcomes has considerably changed from focusing exclusively single nutrients considering combinations foods rather than isolation. is scientifically valid providing crucial evidence mechanisms by impacts health, switch targeting multifaceted synergistic interplay among nutrients, other constituents, whole foods, promoted emerging interest actions total patterns. This narrative review aims describe some patterns with associations reduction incidence allowing older adults live long-lasting healthier confirming powerful can exert healthy aging.

Язык: Английский

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Influence of the Mediterranean Diet on Healthy Aging

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4491 - 4491

Опубликована: Фев. 24, 2023

The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved aging. Likewise, gut microbiota, which influenced by environmental factors such as diet, plays crucial role modulation these mechanisms. Mediterranean well components present it, offer some proof this. Achieving healthy aging should be focused on promotion lifestyle habits reduce development pathologies associated with aging, order to increase quality In this review we analyze influence diet pathways microbiota more favorable patterns, its possible anti-aging treatment.

Язык: Английский

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Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects

The EPMA Journal, Год журнала: 2024, Номер 15(2), С. 207 - 220

Опубликована: Апрель 16, 2024

Язык: Английский

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The Impact of Diet on miRNA Regulation and Its Implications for Health: A Systematic Review

Nutrients, Год журнала: 2024, Номер 16(6), С. 770 - 770

Опубликована: Март 7, 2024

The evidence suggests that diet can modulate endogenous microRNA (miRNA) expression. Changes in miRNA expression may affect metabolic processes and consequently be involved health status disease development. aim of this systematic review was to summarize the role specific food components regulation discuss its implications for human PubMed, Embase Web Science databases were searched accordance with PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines relevant studies. A total 32 interventional 5 observational studies performed adults evaluating dietary modulation included. Energy- fat-controlled diets along plant-based foods show substantial modulating levels. Plasma, serum peripheral blood mononuclear cells (PBMCs) are main sources used measure miRNAs. 108 miRNAs modulated by identified. We confirmed habits closely associated Particularly, energy content fat intake appeared key factors influencing Furthermore, since several biological processes, modulatory process lead disorders.

Язык: Английский

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Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals

Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100376 - 100376

Опубликована: Янв. 1, 2025

Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.

Язык: Английский

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Knowledge, attitudes, and use of the Mediterranean diet in practice among dietitians in the United Arab Emirates: a cross-sectional study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 16, 2025

Dietitians are uniquely positioned to promote the Mediterranean Diet (MedDiet), a diet recognized for its health benefits and sustainability. This study aimed assess knowledge attitudes regarding MedDiet among dietitians in United Arab Emirates (UAE), examine frequency correlates of using this clinical practice. Practicing (n = 220) completed 44-item web-based questionnaire, verified face, content construct validity, as well internal parallel form reliability. Total scores were computed sum items attitudes. The mean score was 6.48 ± 1.85 out 10, with gaps related MedDiet's nutrient composition. Despite positive attitudes, many did not agree that it is easy encourage patients decrease red meat (68%) increase fruits/vegetables intake (70%). In practice, 35% rarely/never used MedDiet. more likely recommend if they had country origin (p 0.037), higher 0.022) attitude 0.013) scores, acquired information about through university education < 0.001) or conferences/seminars/workshops 0.002). Using findings study, evidence-based interventions can be developed support role promoting adherence

Язык: Английский

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The anti-inflammatory effects of a Mediterranean diet: a review

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2022, Номер 25(6), С. 415 - 422

Опубликована: Авг. 30, 2022

Purpose of review Chronic noncommunicable diseases remain the leading cause morbidity and mortality worldwide majority are preventable with a healthy diet lifestyle, but controversy remains as to best approach. Greater adherence traditional Mediterranean has consistently been associated lower from cardiovascular disease, diabetes many cancers, all-cause mortality. Despite well known benefits on chronic disease risk there some scepticism effects this dietary pattern across populations outside mechanisms action plant-based pattern. This narrative aims summarize latest evidence health protective diseases, specifically focussing anti-inflammatory highly published Recent findings high-quality now supports in secondary prevention impacts atherosclerosis progression, likely through reduction systemic inflammation irrespective changes cholesterol or weight. The low Dietary Inflammatory Index illustrating its potential. beneficially modulates gut microbiota immune system, including emerging for efficacy against severe acute respiratory syndrome coronavirus 2 (coronavirus 2019). Emerging shows clinicians not routinely recommending despite due barriers such lack training, patient materials concerns about potential adherence. Summary physiological becoming better understood be multisystem involving gut. Larger controlled trials investigating mechanistic broader non-Mediterranean warranted. Although reflected therapeutic guidelines management individual, clinical practice system implementation that need multisectoral approach address.

Язык: Английский

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The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome

Nutrients, Год журнала: 2022, Номер 14(15), С. 3112 - 3112

Опубликована: Июль 28, 2022

The abnormal expansion of body fat paves the way for several metabolic abnormalities including overweight, obesity, and diabetes, which ultimately cluster under umbrella syndrome (MetS). Patients with MetS are at an increased risk cardiovascular disease, morbidity, mortality. coexistence distinct is associated release pro-inflammatory adipocytokines, as components low-to-medium grade systemic inflammation oxidative stress. Adopting healthy lifestyles, by using appropriate dietary regimens, contributes to prevention treatment MetS. Metabolic can influence function energetic capacity mitochondria, observed in many obesity-related cardio-metabolic disorders. There preclinical studies both cellular animal models, well clinical studies, dealing nutrients Mediterranean diet (MD) dysfunctional mitochondria obesity term "

Язык: Английский

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