Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue

Food Research International, Год журнала: 2023, Номер 167, С. 112730 - 112730

Опубликована: Март 21, 2023

Язык: Английский

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Higher Ultra-Processed Food Consumption Is Associated with Greater High-Sensitivity C-Reactive Protein Concentration in Adults: Cross-Sectional Results from the Melbourne Collaborative Cohort Study

Nutrients, Год журнала: 2022, Номер 14(16), С. 3309 - 3309

Опубликована: Авг. 12, 2022

Background: Few studies have examined associations between ultra-processed food intake and biomarkers of inflammation, inconsistent results been reported in the small number that do exist. As such, further investigation is required. Methods: Cross-sectional baseline data from Melbourne Collaborative Cohort Study (MCCS) were analysed (n = 2018). We applied NOVA classification system to a frequency questionnaire (FFQ) determine (g/day). The outcome was high-sensitivity C-reactive protein concentration (hsCRP; mg/L). fitted unadjusted adjusted linear regression analyses, with sociodemographic characteristics lifestyle- health-related behaviours as covariates. Supplementary analyses for body mass index (kg/m2). Sex assessed possible effect modifier. Ultra-processed modelled 100 g increments magnitude expressed estimated relative change hsCRP accompanying 95% confidence intervals (95%CIs). Results: After adjustment, every increase associated 4.0% (95%CIs: 2.1−5.9%, p < 0.001). showed part this association independent (estimated hsCRP: 2.5%; 95%CIs: 0.8−4.3%, 0.004). No interaction observed sex intake. Conclusion: Higher cross-sectionally elevated hsCRP, which appeared occur index. Future prospective intervention are necessary confirm directionality whether causal.

Язык: Английский

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α‐Dicarbonyl compounds in food products: Comprehensively understanding their occurrence, analysis, and control

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2023, Номер 22(2), С. 1387 - 1417

Опубликована: Фев. 15, 2023

Abstract α‐Dicarbonyl compounds (α‐DCs) are readily produced during the heating and storage of foods, mainly through Maillard reaction, caramelization, lipid‐peroxidation, enzymatic reaction. They contribute to both organoleptic properties (i.e., aroma, taste, color) deterioration foods potential indicators food quality. α‐DCs also important precursors hazardous substances, such as acrylamide, furan, advanced lipoxidation end products, glycation which genotoxic, neurotoxic, linked several diseases. Recent studies have indicated that dietary can elevate plasma α‐DC levels lead “dicarbonyl stress.” To accurately assess their health risks, quantifying in products is crucial. Considering low volatility, inability absorb ultraviolet light, high reactivity, analysis complex systems a challenge. In this review, we comprehensively cover development scientific approaches, from extraction, enrichment, derivatization, sophisticated detection techniques, necessary for different foods. Exposure inevitable because they exist most Recently, novel strategies reducing become hot research topic. These include use new processing technologies, formula modification, supplementation with scavengers (e.g., phenolic compounds). For each strategy, it consider mechanisms underlying formation removal process contaminants. Future needed develop techniques control processing, standardized approaches quantify compare

Язык: Английский

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Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments

Open Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Diabetes-related cognitive impairment is increasingly recognized as a significant complication, profoundly impacting patients' quality of life. This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, future research directions in diabetes. A comprehensive literature search was conducted using PubMed, Medline, other medical databases identify, review, evaluate published articles on The focused studies examining pathophysiology, presentations, diagnostic approaches, strategies. current revealed that chronic hyperglycemia, insulin resistance, vascular factors are major contributing deficits Clinical manifestations include impairments attention, memory, executive function, visuospatial abilities, language. Risk encompass disease duration, glycemic control, presence complications, age, education level, comorbidities. Assessment tools screening instruments, neuropsychological testing, neuroimaging techniques. Management strategies involve control optimization, lifestyle modifications, training, pharmacological interventions. highlights prevalence impact diabetes, resulting from complex metabolic disturbances. Early detection multifaceted interventions crucial for preserving function improving patient outcomes. Future should focus neuroprotective biomarker identification, personalized approaches. Collaborative efforts between clinicians researchers essential effectively address this growing healthcare challenge enhance life individuals with diabetes-related impairment.

Язык: Английский

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Nutrition-related health outcomes of sweet potato (Ipomoea batatas) consumption: A systematic review

Food Bioscience, Год журнала: 2022, Номер 50, С. 102208 - 102208

Опубликована: Ноя. 17, 2022

Язык: Английский

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Advanced Glycation End Products and Nitrosamines in Sausages Influenced by Processing Parameters, Food Additives and Fat during Thermal Processing

Foods, Год журнала: 2023, Номер 12(2), С. 394 - 394

Опубликована: Янв. 13, 2023

Advanced glycation end products (AGEs) and nitrosamines (NAs) in sausage are associated with pathogenic carcinogenic risks. However, the multiple reaction parameters affecting production of AGEs NAs during processing remain unclear. This experiment evaluated effects parameters, food additives fat ratios on formation sausages. The results showed a 2-3-fold increase Nε-(carboxymethyl)lysine (CML) Nε-(carboxyethyl)lysine (CEL) when temperature was increased from 90 °C to 130 °C, N-nitrosodimethylamine (NDEA) 3.68 ng/g 6.41 ng/g. addition salt inhibited NAs, inhibitory ability 2 g/100 g 63.6% for CML 36.5% (NDMA). 10 mg/kg nitrite sausages reduced by 43.9%, however, had significant contribution NAs. only slightly contributed CML. In addition, relationship between α-dicarbonyl compounds investigated measuring changes two trends compounds: AGE level but compound decreased.

Язык: Английский

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Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

Medicinal Research Reviews, Год журнала: 2023, Номер 44(1), С. 365 - 405

Опубликована: Авг. 17, 2023

Diabetes and its complications, Alzheimer's disease (AD), Parkinson's (PD) are increasing gradually, reflecting a global threat vis-à-vis expressing the essentiality of substantial paradigm shift in research remedial actions. Protein glycation is influenced by several factors, like time, temperature, pH, metal ions, half-life protein. Surprisingly, most proteins associated with metabolic neurodegenerative disorders generally long-lived hence susceptible to glycation. Remarkably, linked diabetes, AD, PD share this characteristic. This modulates protein's structure, aggregation tendency, toxicity, highlighting renovated attention. Gut microbes microbial metabolites marked their importance human health diseases. Though many scientific shreds evidence proposed for possible change dysbiosis gut flora these diseases, very little known about mechanisms. Screening unfolding functionality essential hunting treasure. Therefore, it imperative evaluate role as common link diabetes which helps clarify if modulation nonenzymatic may act beneficial therapeutic strategy microbes/metabolites answer some crucial questions. review briefly emphasizes functional attributes microbes, linkages, discusses current treatment options challenges.

Язык: Английский

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Glycation of tilapia protein hydrolysate decreases cellular antioxidant activity upon in vitro gastrointestinal digestion

Food Chemistry X, Год журнала: 2024, Номер 21, С. 101228 - 101228

Опубликована: Фев. 13, 2024

Changes in structural characteristics and antioxidant activity of tilapia hydrolysate glycated with glucose, fructose, or xylose at 90 °C for 12 h, following vitro gastrointestinal (GI) digestion were investigated. Fourier-transformed infrared (FTIR) band between 1,800 1,400 cm−1 confirmed the modifications under glycations. Glycation drastically increased ATBS·+ ONOO-ONOO- scavenging activities (p < 0.05) as well ferric-reducing power (FRAP). Xylose was most effective sugar glycation, yielding highest chemical 0.05). However, hydrolysates exhibited lower cellular (CAA) on HepG2 cell when compared to hydrolysates. The extensive glycation resulted GI digestibility by FTIR spectra CO, CN, NH, CC, CH stretching vibrations. only improved activities, but alleviated CAA, especially upon simulated digestion.

Язык: Английский

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Exosomal Dynamics and Brain Redox Imbalance: Implications in Alzheimer’s Disease Pathology and Diagnosis

Antioxidants, Год журнала: 2024, Номер 13(3), С. 316 - 316

Опубликована: Март 5, 2024

Oxidative burden plays a central role in Alzheimer’s disease (AD) pathology, fostering protein aggregation, inflammation, mitochondrial impairment, and cellular dysfunction that collectively lead to neuronal injury. The of exosomes propagating the pathology neurodegenerative diseases including AD is now well established. However, recent studies have also shown are crucial responders oxidative stress different tissues. Thus, this offers new insights mechanistic links within complex pathogenesis through involvement exosomes. Several indicated exosomes, acting as intracellular communicators, disseminate oxidatively modified contents from one cell another, AD. Another emerging aspect exosome-mediated inhibition ferroptosis multiple tissues under conditions which may well. Apart their AD, enter bloodstream serving novel noninvasive biomarkers for AD; some exosome reflect cerebral condition. This review highlights intricate interplay between dynamics underscores potential tool diagnosis.

Язык: Английский

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Glycative stress as a cause of macular degeneration

Progress in Retinal and Eye Research, Год журнала: 2024, Номер 101, С. 101260 - 101260

Опубликована: Март 21, 2024

Язык: Английский

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