Analytical Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
With the aging global population, incidence of osteoporosis (OP) is increasing, putting more individuals at risk. Since postmenopausal (PMOP) often remains asymptomatic until a fracture occurs, making early clinical diagnosis PMOP particularly challenging. In this work, AuNPs-anchored hierarchical porous ZrO
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(1), С. 177 - 177
Опубликована: Янв. 4, 2024
Marginal vitamin B6 (B6) deficiency is a widespread global concern. Inadequate levels have been linked to an increased risk of age-related chronic diseases such as cardiovascular and cancers. In recent years, the growing concern over sarcopenia (the loss muscle mass strength) frailty (a decline in physiological resilience vulnerability associated with aging) particularly relevant due emergence super-aged societies developed countries. Notably, among thirty-one studies included this review, twenty-five showed significant association status sarcopenia, frailty, all-cause mortality adults (p < 0.05), while six no association. Emerging suggested novel mechanisms underlying These involve P2X7 receptor-mediated NLRP3 inflammasome signaling, AMPK PD-L1 satellite cell-mediated myogenesis. Furthermore, modulation PLP-dependent enzymes impaired metabolic processes, affecting energy utilization, imidazole peptide production, hydrogen sulfide well kynurenine pathway, all which play vital roles skeletal health pathophysiology. This narrative review provides up-to-date assessment our current understanding potential role nutritional combating mortality.
Язык: Английский
Процитировано
15
Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11
Опубликована: Май 31, 2024
The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved various physiological and pathological processes. Indoleamine 2,3-dioxygenase (IDO) (TDO) serve initial pivotal enzymes of KP, IDO playing important intricate roles cardiovascular diseases. Multiple KP have been observed to exhibit elevated concentrations plasma across diseases, such atherosclerosis, hypertension, acute myocardial infarction. studies indicated that (KYN) may a potential biomarker several adverse events. Furthermore, Kynurenine complex inflammation, exhibiting both inhibitory stimulatory effects on inflammatory responses under different conditions. In upregulation stimulates KYN production, mediating aromatic hydrocarbon receptor (AhR)-induced exacerbation vascular inflammation promotion foam cell formation. Conversely, arterial calcification, this mediation alleviates osteogenic differentiation smooth muscle cells. Additionally, cardiac remodeling, KYN-mediated AhR activation exacerbates left ventricular hypertrophy fibrosis. Interventions targeting components inhibitors, 3-hydroxyanthranilic acid, anthranilic demonstrate protective effects. This review outlines mechanistic coronary highlighting diagnostic, prognostic, therapeutic value thus providing novel insights development application related drugs future research.
Язык: Английский
Процитировано
15
Journal of Pineal Research, Год журнала: 2024, Номер 76(3)
Опубликована: Апрель 1, 2024
Abstract Osteoporosis (OP) is a severe global health issue that has significant implications for productivity and human lifespan. Gut microbiota dysbiosis been demonstrated to be closely associated with OP progression. Melatonin (MLT) an important endogenous hormone modulates bone metabolism, maintains homeostasis, improves Multiple studies indicated MLT participates in the regulation of intestinal gut barrier function. However, promising effects microbiota‐derived remain unclear. Here, we found resulted tryptophan disorder decreased production MLT, while administration could mitigate OP‐related clinical symptoms reverse dysbiosis, including diversity microbiota, relative abundance many probiotics such as Allobaculum Parasutterella , metabolic function flora amino acid nucleotide energy metabolism. Notably, significantly increased short‐chain fatty acids trimethylamine N‐oxide‐related metabolites. Importantly, modulate dynamic balance M1/M2 macrophages, reduce serum levels pro‐inflammatory cytokines, restore gut‐barrier Taken together, our results highlighted roles microbially derived progression via “gut‐bone” axis SCFA which may provide novel insight into development drug treating OP.
Язык: Английский
Процитировано
10
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8474 - 8474
Опубликована: Авг. 3, 2024
Chronic kidney disease (CKD) is a progressive disorder associated with decline in function. Consequently, patients advanced stages of CKD require renal replacement therapies, such as dialysis and transplantation. Various conditions lead to the development CKD, including diabetes mellitus, hypertension, glomerulonephritis, among others. The metabolic hormonal dysregulation, uraemia hyperparathyroidism, well low-grade systemic inflammation. Altered homeostasis increases risk developing severe comorbidities, cardiovascular diseases or sarcopenia, which increase mortality. Sarcopenia defined muscle mass However, precise mechanisms that link sarcopenia are poorly understood. Knowledge about these linking might introduction treatment strategies could prevent wasting. This review discusses inflammatory mediators, gut microbiota dysbiosis, non-coding RNA alterations sarcopenia.
Язык: Английский
Процитировано
5
PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0313193 - e0313193
Опубликована: Янв. 2, 2025
Introduction Sarcopenia and Osteoporosis are two prevalent conditions in the older population defined by low strength, muscle quality/volume Bone Mineral Density, respectively. When there is a concomitant presence of both, novel musculoskeletal condition called Osteosarcopenia. These adversely affect quality life elevate risk fractures, disability, mortality among individuals. Dysbiosis gut microbiota impairment mutualistic relationship between microorganisms, metabolic products host’s immune system. Gut dysbiosis could be intricately linked to sarcopenia osteoporosis, shedding light on complex microbiota-gut-bone-muscle axis. Furthermore, intestinal experiences notable decline beneficial microorganisms as part aging process. The people sarcopenia, osteoporosis or osteosarcopenia still unclear. This review protocol aims systematically literature compile evidence influence function with osteosarcopenia. Methods/Analysis systematic will analyze observational studies that have investigated effects aged 65 over. Studies retrieved from PubMed/MEDLINE, EMBASE, Scopus, Web Science Cochrane Library. Outcome measures include body composition for diagnosing screening sarcopenia/osteosarcopenia any criteria. Data synthesis involve quantitative analysis using summary measures. If sufficient studies, homogeneity heterogeneity performed conduct Meta-analysis pooled OR, RR HR provided.
Язык: Английский
Процитировано
0
Frontiers in Sports and Active Living, Год журнала: 2025, Номер 7
Опубликована: Март 6, 2025
Background Tryptophan (TRP) metabolism through the kynurenine (KYN) pathway is influenced by inflammatory mediators, generating metabolites that regulate immune and responses. Exercise has been proposed as a modulator of this pathway, but its role in health benefits chronic disease management remains unclear. Objective This systematic review examines exercise-induced adaptations KYN their potential implications for management. Additionally, we identify key methodological considerations future research. Methods A structured search PubMed/Medline, Web Science, Scopus was conducted up to October 2024 clinical trials investigating effects exercise training on pathway. Results Of 2,795 articles initially found, 13 involving 592 participants met inclusion criteria. Most studies reported particularly cancer survivors. These appeared be intensity duration. However, several limitations were noted, no included patients with metabolic or cardiovascular diseases. Conclusions Here, show modulates both healthy diseased populations, highlighting prevention further randomized-controlled are needed clarify mechanisms applications, Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481 , PROSPERO (CRD42022351481).
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Фев. 5, 2025
Background Elderly individuals with inadequate vitamin B level are at increased risk of degenerative conditions, notably cardiovascular disorders, cognitive impairments, and osteoporosis. The relationship between niacin (vitamin B3) consumption osteoporosis remains a subject debate. This study aimed to clarify the dietary intake incidence in postmenopausal women aged ≥50 years. Methods In this study, we gathered details on participants’ bone mineral density, status, intake, several other critical variables. Multivariate logistic regression models were constructed determine association Restricted cubic splines employed further assess linearity explore shape dose-response associations. Additionally, performed stratified interaction analyses illustrate stability observed relationships across different subgroups. Results After adjusting for all covariates, there was significant inverse (OR = 0.87; 95% CI: 0.77–0.97; p 0.016). A negative (nonlinear: 0.672). While revealed some differences risk, these not statistically significant. Conclusion Dietary exhibited an correlation significantly reduced by 13% every 10 mg/day increase daily among women.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2024, Номер 329, С. 118130 - 118130
Опубликована: Март 31, 2024
Язык: Английский
Процитировано
3
Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2024, Номер 246, С. 116198 - 116198
Опубликована: Май 7, 2024
Язык: Английский
Процитировано
3