Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 993, P. 177413 - 177413

Published: Feb. 21, 2025

Language: Английский

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Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(10)

Published: May 1, 2024

Abstract Skeletal muscle can undergo detrimental changes in various diseases, leading to dysfunction and atrophy, thus severely affecting people's lives. Along with exercise, there is a growing interest the potential of nutritional support against atrophy. This review provides brief overview molecular mechanisms driving skeletal atrophy summarizes recent advances interventions for preventing treating The supplements include amino acids their derivatives (such as leucine, β‐hydroxy, β‐methylbutyrate, creatine), antioxidant (like Coenzyme Q10 mitoquinone, resveratrol, curcumin, quercetin, Omega 3 fatty acids), minerals magnesium selenium), vitamins vitamin B, C, D, E), well probiotics prebiotics Lactobacillus, Bifidobacterium, 1‐kestose). Furthermore, study discusses impact combined approach involving physical therapy prevent suggests appropriate multi‐nutritional multi‐modal based on individual conditions optimize treatment outcomes, enhances recovery function patients. By understanding behind implementing interventions, it possible enhance improve patients' quality life.

Language: Английский

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The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1635 - 1635

Published: May 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Language: Английский

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Causal Relationship Between Circulating Metabolites and Sarcopenia‐Related Traits: A Mendelian Randomization and Experimental Study

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Sarcopenia (SP), an age‐associated condition marked by muscle weakness and loss has been strongly connected with metabolic factors according to substantial evidence. Nevertheless, the causal correlation between SP serum metabolites, biological signaling pathways involved, is still not well understood. We performed a bidirectional two‐sample Mendelian randomization (MR) analysis examine relationships 1091 levels 309 ratios of metabolites traits, alongside investigating relevant pathways. Additionally, we explored differential expression plasma potential in animal model SP. When was utilized as outcome, identified 11 robust associations seven metabolite levels/ratios SP‐related traits using Bonferroni's correction (threshold: p < 0.05). verified stable association glycine validation. As for reverse MR analysis, there were strong remaining after multiple contrast correction. pathway showed that metabolism, insulin resistance, cAMP may contribute connection validation various datasets observations metabolomics suggests metabolism Our results indicate biosignaling could serve important circulatory biomarkers screening prevention clinical settings. they represent molecules future exploration mechanisms selection drug targets.

Language: Английский

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Muscle mass mediates the association between dietary diversity and mortality among the older adults: a prospective cohort study

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 47, P. 21 - 27

Published: Feb. 11, 2025

Language: Английский

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Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Frailty is an age-related geriatric syndrome, for which the mechanisms remain largely unknown. We performed a longitudinal study of aging female (n = 40) and male 47) C57BL/6NIA mice, measured frailty index derived metabolomics data from plasma samples. identify differentially abundant metabolites related to aging, determine via machine learning approach, generate union set features, both in whole cohort sex-stratified subgroups. Using we perform association build metabolomics-based clock. find that are enriched amino acid metabolism cofactors vitamins, include ergothioneine, tryptophan, alpha-ketoglutarate, present sex dimorphism. B vitamin flavin adenine dinucleotide pyridoxate as female-specific biomarkers, lipid sphingomyelins, glycerophosphoethanolamine glycerophosphocholine male-specific biomarkers. These associations confirmed validation cohort, with ergothioneine perfluorooctanesulfonate identified robust In summary, our results sex-specific metabolite biomarkers shed light on potential involved frailty.

Language: Английский

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Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1967 - 1967

Published: Feb. 25, 2025

Water-soluble B vitamins, mainly obtained through dietary intake of fruits, vegetables, grains, and dairy products, act as co-factors in various biochemical processes, including DNA synthesis, repair, methylation, energy metabolism. These vitamins include B1 (Thiamine), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6 (Pyridoxine), B7 (Biotin), B9 (Folate), B12 (Cobalamin). Recent studies have shown that besides their fundamental physiological roles, influence oncogenic metabolic pathways, glycolysis (Warburg effect), mitochondrial function, nucleotide biosynthesis. Although deficiencies these are associated with several complications, emerging evidence suggests excessive specific may also contribute to cancer progression interfere therapy due impaired genetic functions. This review discusses the tumor-suppressive tumor-progressive roles cancer. It explores recent on a comprehensive understanding relationship between vitamin metabolism underscores need for further research determine optimal balance prevention therapy.

Language: Английский

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Investigation of the association between the triglyceride-glucose index and the incidence of frailty among middle-aged and older adults: evidence from the China health and retirement longitudinal study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 30, 2025

Aim Limited researches have investigated the association between Triglyceride-glucose index (TyG) and frailty vulnerability in middle-aged older Chinese populations. This study aims to strengthen scientific foundation for prevention management by analyzing correlation TyG frailty, ultimately providing more targeted intervention strategies. Methods included individuals who participated China Health Retirement Longitudinal Study (CHARLS) from 2015. A multiple logistic regression model was constructed assess frailty. Additionally, restricted cubic spline (RCS) analysis employed evaluate dose–response two variables. Results Among 3,978 participants study, 667 (16.8%) were identified with After adjusting factors a model, it determined that highest quartile group of had 1.43 times higher risk compared those lowest (OR = 1.43, 95% CI: 1.10 ~ 1.85, p 0.007). The RCS further revealed positive relationship, indicating associated an increased adults. Conclusion Research has shown significant linear relationship prevalence individuals. Elevated levels could signal among

Language: Английский

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Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9962 - 9962

Published: Sept. 15, 2024

Marginal vitamin B6 (B6) deficiency is common in various segments worldwide. In a super-aged society, sarcopenia major concern and has gained significant research attention focused on healthy aging. To date, the primary interventions for have been physical exercise therapy. Recent evidence suggests that inadequate status associated with an increased risk of mortality among older adults. Our previous study showed supplementation to marginal B6-deficient diet up-regulated expression exercise-induced genes skeletal muscle rodents. Notably, supplemental B6-to-B6-deficient stimulates satellite cell-mediated myogenesis rodents, mirroring effects exercise. These findings suggest potential role as exercise-mimetic nutrient muscle. test this hypothesis, we reviewed relevant literature compared roles muscles. Here, provide several pieces supporting hypothesis discuss mechanisms behind similarities between This research, first time, provides insight into

Language: Английский

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Association of the oxidative balance score with sarcopenia among young and middle-aged adults: findings from NHANES 2011–2018

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 4, 2024

Background Sarcopenia is associated with oxidative stress. The Oxidative Balance Score (OBS) commonly used to assess dietary and lifestyle exposure However, few studies in the literature have assessed correlation between sarcopenia OBS. Aim This study aimed association OBS among young middle-aged adults United States using data from National Health Nutrition Examination Survey (NHANES). Method Weighted logistic regression analysis was investigate based on NHANES 2011–2018. Subgroup analyses were performed observe consistency of outcomes, stability results tested sensitivity analyses. Result final sample included 5,525 American adults. A higher a lower risk sarcopenia. In fully adjusted model, second (odds ratio [OR]: 0.62, 95% confidence interval [CI]: 0.41, 0.94; p = 0.023), third (OR: 0.50; CI: 0.34, 0.74; &lt; 0.001), highest quartiles 0.18; 0.11, 0.28; 0.001) risks when compared lowest quartile. consistent across both scores. Our subgroup revealed no significant differences subgroups variables interaction analysis. Sensitivity similar results. Conclusion showed that antioxidant may decrease developing Higher scores indicate greater protection against sarcopenia; however, further clinical are warranted confirm these findings.

Language: Английский

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