Composites Communications, Год журнала: 2025, Номер unknown, С. 102362 - 102362
Опубликована: Март 1, 2025
Язык: Английский
European Polymer Journal, Год журнала: 2024, Номер 210, С. 112983 - 112983
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
47
Carbohydrate Research, Год журнала: 2024, Номер 542, С. 109199 - 109199
Опубликована: Июнь 27, 2024
Язык: Английский
Процитировано
36
Cell Biochemistry and Function, Год журнала: 2024, Номер 42(1)
Опубликована: Янв. 1, 2024
Abstract Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness limited due to poor absorption rapid elimination the body. Various curcumin derivatives have also shown anticancer potential in‐vitro in‐vivo models. multiple signaling pathways development/progression or induce cell death through apoptosis. In addition, could enhance of conventional chemotherapy, radiation therapy reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored overcome challenges with curcumin's delivery, increasing overall efficacy. The use an imaging system track these formulations give beneficial information about bioavailability distribution nano‐curcumin complex. conclusion, holds significant promise fight against cancer, especially nanoform, provide precise cells without affecting normal healthy cells.
Язык: Английский
Процитировано
18
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132916 - 132916
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
18
Microchimica Acta, Год журнала: 2025, Номер 192(2)
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
2
Polysaccharides, Год журнала: 2025, Номер 6(1), С. 11 - 11
Опубликована: Фев. 5, 2025
Chitosan remains one of the most widely used biopolymers in biomedicine due to its non-toxicity and biodegradability. It is easily chemically modified, allowing properties be effectively altered improve performance as a gene drug carrier. The introduction hydrophobic moieties into chitosan can significantly enhance interaction with cancer cells, improving potential for targeted delivery. moiety plays crucial role particle cell membrane during internalization by endocytosis. type moiety, degree substitution, placement along backbone all influence physicochemical biological resulting polymer. Hydrophobic modification also affect self-assembly behavior chitosan, influencing size, shape, stability particles. These factors impact loading efficiency therapeutic agents release kinetics encapsulated cargo. While efficacy it important consider toxic effects. In summary, powerful strategy By understanding cellular uptake, endosomal escape, self-assembly, toxicity, researchers design develop optimized chitosan-based delivery systems therapy.
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2023, Номер 15(9), С. 2361 - 2361
Опубликована: Сен. 21, 2023
Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common method, although it not always effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One significant barriers that medications must overcome to exert a therapeutic effect impact first hepatic transit. Studies shown controlled-release systems using nanoparticles composed biodegradable natural polymers significantly improve administration, which why these materials attracted attention. Chitosan possesses wide variety properties functions pharmaceutical well healthcare industries. Drug encapsulation transport within body are two its important features. Moreover, chitosan can enhance efficacy by facilitating interaction target cells. Based on physicochemical properties, potentially be synthesized into nanoparticles, this review summarizes advances applications orally delivered nanoparticle interventions.
Язык: Английский
Процитировано
25
Marine Drugs, Год журнала: 2024, Номер 22(4), С. 153 - 153
Опубликована: Март 28, 2024
Shrimp processing generates substantial waste, which is rich in valuable components such as polysaccharides, proteins, carotenoids, and fatty acids. This review provides a comprehensive overview of the valorization shrimp mainly shells, focusing on extraction methods, bioactivities, potential applications these bioactive compounds. Various techniques, including chemical extraction, microbial fermentation, enzyme-assisted microwave-assisted ultrasound-assisted pressurized techniques are discussed, highlighting their efficacy isolating acids from waste. Additionally, bioactivities associated with compounds, antioxidant, antimicrobial, anti-inflammatory, antitumor properties, among others, elucidated, underscoring pharmaceutical, nutraceutical, cosmeceutical applications. Furthermore, explores current utilization avenues for emphasizing importance sustainable resource management circular economy principles maximizing value Overall, this paper aims to provide insights into multifaceted aspects waste valorization, offering information researchers, industries, policymakers interested waste-management strategies.
Язык: Английский
Процитировано
15
Journal of Nanomaterials, Год журнала: 2024, Номер 2024, С. 1 - 48
Опубликована: Апрель 12, 2024
Nanotechnology has emerged as a promising field in pharmaceutical research, involving producing unique nanoscale materials with sizes up to 100 nm via physiochemical and biological approaches. Nowadays more emphasis been given eco-friendly techniques for developing nanomaterials enhance their applications minimize health environmental risks. With the help of green nanotechnology, wide range metal, metal oxide, bimetallic nanoparticles distinct chemical compositions, sizes, morphologies have manufactured which are safe, economical, environment friendly. Due biocompatibility vast potential biomedical (antibacterial, anticancer, antiviral, analgesic, anticoagulant, biofilm inhibitory activity) other fields such (nanofertilizers, fermentative, food, bioethanol production, construction field), garnered significant interest worldwide. The precursors combined natural extracts plants, algae, fungi, bacteria get potent novel Ag, Au, Co, Cu, Fe, Zr, Zn, Ni, Pt, Mg, Ti, Pd, Cd, Bi2O3, CeO2, Co3O4, CoFe2O4, CuO, Fe2O3, MgO, NiO, TiO2, ZnO, ZrO2, Ag-Au, Ag-Cr, Ag-Cu, Ag-Zn, Ag-CeO2, Ag-CuO, Ag-SeO2, Ag-TiO2, Ag-ZnO, Cu-Ag, Cu-Mg, Cu-Ni, Pd-Pt, Pt-Ag, ZnO-CuO, ZnO-SeO, ZnO-Se, Se-Zr, Co-Bi2O3. These plant-mediated possess excellent antibacterial anticancer activity when tested against several microorganisms cancer cell lines. Plants contain essential phytoconstituents (polyphenols, flavonoids, terpenoids, glycosides, alkaloids, etc.) compared sources (bacteria, algae) higher concentration that play vital role development because these plant-phytoconstituents act reducing, stabilizing, capping agent helps nanoparticles. After concluding all findings, this review designed first time way it imparts satisfactory knowledge about together, along mechanisms. Additionally, provides information characterization (UV–vis, FT-IR, DLS, XRD, SEM, TEM, BET, AFM) employed nanoparticles, applications, industries. Hence, various types versatile application diverse is not covered pieces literature.
Язык: Английский
Процитировано
13
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)
Опубликована: Май 1, 2024
Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives
Язык: Английский
Процитировано
11