Biology,
Год журнала:
2023,
Номер
12(7), С. 976 - 976
Опубликована: Июль 10, 2023
The
immune
system
plays
an
important
role
in
the
skeletal
during
bone
repair
and
regeneration.
controlled
release
of
biological
factors
from
could
facilitate
optimize
remodeling
process
through
regulation
activities
cells.
This
study
aimed
to
determine
effect
delivery
immunomodulatory
biologicals
on
Immunostimulatory
cytosine-phosphate-guanosine
oligodeoxynucleotides
(CpG
ODN)
glucosylxanthone
Mangiferin
(MAG)-embedded
microbeads
were
incubated
with
P.
gingivalis-challenged
splenocytes,
or
co-cultured
RAW264.7
CpG
ODN/MAG-containing
regeneration
was
then
tested
vivo
a
mouse
alveolar
defect
model.
results
demonstrated
that
MAG
significantly
antagonized
gingivalis
proliferation
reduced
live/dead
cell
ratio.
After
addition
ODN
+
microbeads,
anti-inflammatory
cytokines
IL-10
IL-4
upregulated
day
2
but
not
4,
whereas
pro-inflammatory
cytokine
IL-1β
responses
showed
no
difference
at
both
timepoints.
RANKL
production
by
splenocytes
TRAP+
formation
cells
inhibited
microbeads.
Alveolar
bony
defects,
filled
increased
new
after
4
weeks.
In
summary,
this
evaluated
hydrogel-based
regimen
for
local
regenerate
defects.
combined
treatment
may
promote
anti-microbial/anti-inflammatory
effects
inhibition
RANKL-mediated
osteoclastogenesis.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(15), С. 3719 - 3740
Опубликована: Янв. 1, 2024
A
whole-course-repair
system
based
on
ROS/glucose
dual
responsive,
injectable
and
multifunctional
hydrogel
to
release
EGCG
is
reported
for
the
treatment
of
CPDM.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(4), С. 2414 - 2425
Опубликована: Март 6, 2024
Bone
defects
are
a
common
and
challenging
orthopedic
problem
with
poor
self-healing
ability
long
treatment
cycles.
The
difficult-to-heal
bone
cause
significant
burden
of
medical
expenses
on
patients.
Currently,
biomaterials
mechanical
stability,
long-lasting
action,
osteogenic
activity
considered
as
suitable
way
to
effectively
heal
defects.
Here,
an
injectable
double
network
(DN)
hydrogel
prepared
using
physical
chemical
cross-linking
methods
is
designed.
first
rigid
constructed
methylpropenylated
hyaluronic
acid
(HAMA),
while
the
addition
chitosan
oligosaccharide
(COS)
forms
second
flexible
by
cross-linking.
mesoporous
silica
nanoparticles
(MSN)
loaded
morphogenetic
protein-4
(BMP-4)
were
embedded
into
DN
hydrogel,
which
not
only
enhanced
stability
but
also
slowly
released
BMP-4
achieve
long-term
skull
repair.
designed
composite
showed
excellent
compression
property
deformation
resistance.
In
vitro
studies
confirmed
that
HAMA/COS/MSN@BMP-4
had
good
biocompatibility
great
potential
in
supporting
proliferation
differentiation
mouse
embryo
osteoblast
precursor
(MC3T3-E1)
cells.
Furthermore,
vivo
successfully
filled
closed
irregular
defect
wounds,
promoted
regeneration,
significantly
repair
compared
control
group.
addition,
solution
can
quickly
form
situ
at
wound
ultraviolet
light,
be
applied
closure
wounds
different
shapes,
provides
new
for
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 789 - 789
Опубликована: Июнь 28, 2024
Bone
defects
caused
by
trauma,
tumor
resection,
and
infections
are
significant
clinical
challenges.
Excessive
reactive
oxygen
species
(ROS)
usually
accumulate
in
the
defect
area,
which
may
impair
function
of
cells
involved
bone
formation,
posing
a
serious
challenge
for
repair.
Due
to
potent
ROS
scavenging
ability,
as
well
potential
anti-inflammatory
immunomodulatory
activities,
antioxidants
play
an
indispensable
role
maintenance
protection
health
have
gained
increasing
attention
recent
years.
This
narrative
review
aims
give
overview
main
research
directions
on
application
antioxidant
compounds
repair
over
past
decade.
In
addition,
positive
effects
various
their
biomaterial
delivery
systems
summarized
provide
new
insights
exploring
antioxidant-based
strategies
