Livers,
Год журнала:
2023,
Номер
3(2), С. 161 - 189
Опубликована: Март 27, 2023
More
than
90%
of
all
liver
malignancies
are
hepatocellular
carcinomas
(HCCs),
for
which
chemotherapy
and
immunotherapy
the
ideal
therapeutic
choices.
Hepatocellular
carcinoma
is
descended
from
other
diseases,
such
as
viral
hepatitis,
alcoholism,
metabolic
syndrome.
Normal
cells
tissues
may
suffer
damage
common
forms
chemotherapy.
In
contrast
to
systemic
chemotherapy,
localized
can
reduce
side
effects
by
delivering
a
steady
stream
chemotherapeutic
drugs
directly
tumor
site.
This
highlights
significance
controlled-release
biodegradable
hydrogels
drug
delivery
methods
chemotherapeutics.
review
discusses
using
systems
HCC
covers
thermosensitive,
pH-sensitive,
photosensitive,
dual-sensitive,
glutathione-responsive
hydrogels.
Compared
conventional
hydrogel-based
more
effective
in
treating
cancer.
ACS Nano,
Год журнала:
2022,
Номер
16(7), С. 9994 - 10041
Опубликована: Июнь 22, 2022
Worldwide
nanotechnology
development
and
application
have
fueled
many
scientific
advances,
but
technophilic
expectations
technophobic
demands
must
be
counterbalanced
in
parallel.
Some
of
the
burning
issues
today
are
following:
(1)
Where
is
nano
today?
(2)
How
good
communication
investment
networks
between
academia/research
governments?
(3)
Is
there
any
spotlight
for
nanotechnology?
Nanomedicine
a
particular
arm
within
healthcare
landscape,
focused
on
diagnosis,
treatment,
monitoring
emerging
(such
as
coronavirus
disease
2019,
COVID-19)
contemporary
(including
diabetes,
cardiovascular
diseases,
neurodegenerative
disorders,
cancer)
diseases.
However,
it
may
only
represent
bright
side
coin.
In
fact,
recent
past,
concept
nanotoxicology
has
emerged
to
address
dark
shadows
nanomedicine.
The
nanomedicine
field
requires
more
nanotoxicological
studies
identify
undesirable
effects
guarantee
safety.
Here,
we
provide
an
overall
perspective
central
pieces
giant
puzzle
nanotechnology.
First,
impact
education
research
highlighted,
followed
by
market
trends
output
tendencies.
next
section,
dilemma
addressed
through
interplay
silico,
vitro,
vivo
models
with
support
omics
microfluidic
approaches.
Lastly,
reflection
regulatory
clinical
trials
provided.
Finally,
some
conclusions
future
perspectives
proposed
clearer
safer
translation
nanomedicines
from
bench
bedside.
Polymers,
Год журнала:
2023,
Номер
15(15), С. 3177 - 3177
Опубликована: Июль 26, 2023
The
recycling
of
biomass
into
high-value-added
materials
requires
important
developments
in
research
and
technology
to
create
a
sustainable
circular
economy.
Lignin,
as
component
biomass,
is
multipurpose
aromatic
polymer
with
significant
potential
be
used
renewable
bioresource
many
fields
which
it
acts
both
promising
biopolymer
bioactive
compound.
This
comprehensive
review
gives
brief
insights
the
recent
technological
trends
on
lignin
development
utilization.
It
divided
ten
main
sections,
starting
an
outlook
its
diversity;
properties
possibilities
raw
material
for
fuels,
chemicals,
plastics,
or
thermoset
substitutes;
new
use
compound
nanoparticles,
hydrogels,
3D-printing-based
biomaterials,
energy
production
storage.
In
each
section
are
presented
preparation
lignin-based
especially
green
approaches
obtaining
multifunctional
blends
bio(nano)composites;
most
suitable
type
category
envisaged
products;
obtained
materials,
etc.
Different
application
categories
within
various
sectors,
could
provide
completely
conversion,
such
agriculture
environment
protection,
food
packaging,
biomedicine,
cosmetics,
also
described.
medical
therapeutic
lignin-derived
evidenced
applications
antimicrobial,
antiviral,
antitumor
agents;
carriers
drug
delivery
systems
controlled/targeting
release;
tissue
engineering
wound
healing;
coatings,
natural
sunscreen,
surfactants.
Lignin
mainly
fuel,
and,
recently,
studies
highlighted
more
bioenergy
technologies,
supercapacitor
electrode,
photocatalysts,
photovoltaics.
RSC Advances,
Год журнала:
2023,
Номер
13(31), С. 21345 - 21364
Опубликована: Янв. 1, 2023
Nanoparticle-modified
hydrogels
exhibit
substantial
promise
in
the
realm
of
wound
healing,
with
their
ability
to
expedite
tissue
regeneration,
mitigate
infection
risks,
and
facilitate
enhanced
therapeutic
outcomes.
RSC Advances,
Год журнала:
2024,
Номер
14(19), С. 13535 - 13564
Опубликована: Янв. 1, 2024
Nanoparticle-hydrogel
systems
are
versatile
biomaterials
that
possess
numerous
advantages
for
biomedical
applications.
This
review
focuses
on
the
application
of
nanoparticle-hydrogels
system
delivery
antimicrobial
agents.
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(10), С. 105968 - 105968
Опубликована: Авг. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
Nanomedicine
has
the
potential
to
transform
healthcare
by
offering
targeted
therapies,
precise
diagnostics,
and
enhanced
drug
delivery
systems.
The
National
Institutes
of
Health
coined
term
"nanomedicine"
describe
use
nanotechnology
in
biological
system
monitoring,
control,
diagnosis,
treatment.
continues
receive
increasing
interest
for
rationalized
therapeutics
pharmaceutical
agents
achieve
required
response
while
reducing
its
side
effects.
However,
as
advance,
concerns
about
toxicological
effects
have
also
grown.
This
review
explores
current
state
nanomedicine,
focusing
on
types
nanoparticles
used
their
associated
properties
that
contribute
nanotoxicity.
It
examines
mechanisms
through
which
exert
toxicity,
encompassing
various
cellular
molecular
interactions.
Furthermore,
it
discusses
assessment
methods
employed
evaluate
nanotoxicity,
in-vitro
in-vivo
models,
well
emerging
techniques.
addresses
regulatory
issues
surrounding
nanotoxicology,
highlighting
challenges
developing
standardized
guidelines
ensuring
secure
translation
nanomedicine
into
clinical
settings.
ethical
with
understanding
safety
profile
is
essential
effective
therapeutic
applications.
This
review
explores
the
potential
of
polymeric
nanoparticles
(PNPs)
as
targeted
drug
delivery
systems
for
arthritic
treatment,
overcoming
limitations
present
therapy.
A
thorough
literature
search
was
conducted
on
databases
PubMed,
Scopus,
and
Web
Science
to
find
published
articles
use
in
treatment
arthritis.
includes
synthesis
methods,
mechanisms
delivery,
applications
PNPs.
Polymeric
showed
excellent
promise
management
arthritis
through
enhanced
stability
drugs,
controlled
sustained
release,
reduced
systemic
side
effects.
Some
highlighted
biocompatible
targeting
capabilities
natural
synthetic
polymers
include
chitosan,
hyaluronic
acid,
PLGA.
Bioactive
compounds
such
curcumin
resveratrol
delivered
by
PNPs
therapeutic
efficacy
preclinical
models.
Despite
their
promise,
challenges
rapid
clearance
manufacturing
scalability
remain
critical
barriers.
offer
a
transformative
approach
enabling
targeted,
sustained,
safe
delivery.
Translation
into
clinical
would
thus
require
developments
nanoparticle
design,
personalized
medicine,
scalable
production
techniques.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7286 - 7286
Опубликована: Апрель 14, 2023
The
nervous
and
immune
systems
go
hand
in
causing
inflammation
pain.
However,
the
two
are
not
mutually
exclusive.
While
some
diseases
cause
inflammation,
others
caused
by
it.
Macrophages
play
an
important
role
modulating
to
trigger
neuropathic
Hyaluronic
acid
(HA)
is
a
naturally
occurring
glycosaminoglycan
that
has
well-known
ability
bind
with
cluster
of
differentiation
44
(CD44)
receptor
on
classically
activated
M1
macrophages.
Resolving
varying
molecular
weight
HA
debated
concept.
HA-based
drug
delivery
nanosystems
such
as
nanohydrogels
nanoemulsions,
targeting
macrophages
can
be
used
relieve
pain
loading
antinociceptive
drugs
enhancing
effect
anti-inflammatory
drugs.
This
review
will
discuss
ongoing
research
regarding
their
effects.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 879 - 879
Опубликована: Март 8, 2023
Despite
recent
advances,
cancer
remains
the
primary
killer
on
a
global
scale.
Numerous
forms
of
research
have
been
conducted
to
discover
novel
and
efficient
anticancer
medications.
The
complexity
breast
is
major
challenge
which
coupled
with
patient-to-patient
variations
heterogeneity
between
cells
within
tumor.
Revolutionary
drug
delivery
expected
provide
solution
that
challenge.
Chitosan
nanoparticles
(CSNPs)
prospects
as
revolutionary
system
capable
enhancing
activity
reducing
negative
impacts
normal
cells.
use
smart
systems
(SDDs)
delivering
materials
improve
bioactivity
NPs
understand
intricacies
has
garnered
significant
interest.
There
are
many
reviews
about
CSNPs
present
various
points
view,
but
they
not
yet
described
series
in
therapy
from
cell
uptake
death.
With
this
description,
we
will
more
complete
picture
for
designing
preparations
SDDs.
This
review
describes
SDDSs,
targeting
stimulus
response
using
their
mechanism.
Multimodal
chitosan
SDDs
medication
therapeutic
results.
