An Updated Review on Advances in Hydrogel-Based Nanoparticles for Liver Cancer Treatment DOI Creative Commons
Bahareh Farasati Far, Ali Attaripour Isfahani, Elnaz Nasiriyan

и другие.

Livers, Год журнала: 2023, Номер 3(2), С. 161 - 189

Опубликована: Март 27, 2023

More than 90% of all liver malignancies are hepatocellular carcinomas (HCCs), for which chemotherapy and immunotherapy the ideal therapeutic choices. Hepatocellular carcinoma is descended from other diseases, such as viral hepatitis, alcoholism, metabolic syndrome. Normal cells tissues may suffer damage common forms chemotherapy. In contrast to systemic chemotherapy, localized can reduce side effects by delivering a steady stream chemotherapeutic drugs directly tumor site. This highlights significance controlled-release biodegradable hydrogels drug delivery methods chemotherapeutics. review discusses using systems HCC covers thermosensitive, pH-sensitive, photosensitive, dual-sensitive, glutathione-responsive hydrogels. Compared conventional hydrogel-based more effective in treating cancer.

Язык: Английский

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology DOI
Cátia Domingues, Ana Cláudia Paiva‐Santos, Carmen Alvarez‐Lorenzo

и другие.

ACS Nano, Год журнала: 2022, Номер 16(7), С. 9994 - 10041

Опубликована: Июнь 22, 2022

Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.

Язык: Английский

Процитировано

131

Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials DOI Open Access
Cornelia Vasile,

Mihaela Baican

Polymers, Год журнала: 2023, Номер 15(15), С. 3177 - 3177

Опубликована: Июль 26, 2023

The recycling of biomass into high-value-added materials requires important developments in research and technology to create a sustainable circular economy. Lignin, as component biomass, is multipurpose aromatic polymer with significant potential be used renewable bioresource many fields which it acts both promising biopolymer bioactive compound. This comprehensive review gives brief insights the recent technological trends on lignin development utilization. It divided ten main sections, starting an outlook its diversity; properties possibilities raw material for fuels, chemicals, plastics, or thermoset substitutes; new use compound nanoparticles, hydrogels, 3D-printing-based biomaterials, energy production storage. In each section are presented preparation lignin-based especially green approaches obtaining multifunctional blends bio(nano)composites; most suitable type category envisaged products; obtained materials, etc. Different application categories within various sectors, could provide completely conversion, such agriculture environment protection, food packaging, biomedicine, cosmetics, also described. medical therapeutic lignin-derived evidenced applications antimicrobial, antiviral, antitumor agents; carriers drug delivery systems controlled/targeting release; tissue engineering wound healing; coatings, natural sunscreen, surfactants. Lignin mainly fuel, and, recently, studies highlighted more bioenergy technologies, supercapacitor electrode, photocatalysts, photovoltaics.

Язык: Английский

Процитировано

74

Wound healing strategies based on nanoparticles incorporated in hydrogel wound patches DOI Creative Commons
Paulami Dam, Merve Celik, Merve Ustun

и другие.

RSC Advances, Год журнала: 2023, Номер 13(31), С. 21345 - 21364

Опубликована: Янв. 1, 2023

Nanoparticle-modified hydrogels exhibit substantial promise in the realm of wound healing, with their ability to expedite tissue regeneration, mitigate infection risks, and facilitate enhanced therapeutic outcomes.

Язык: Английский

Процитировано

55

Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends DOI Creative Commons
Naveed Ahmad, Syed Nasir Abbas Bukhari, Muhammad Ajaz Hussain

и другие.

RSC Advances, Год журнала: 2024, Номер 14(19), С. 13535 - 13564

Опубликована: Янв. 1, 2024

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.

Язык: Английский

Процитировано

42

Locoregional drug delivery for cancer therapy: Preclinical progress and clinical translation DOI
Suyog Shaha, Danika Rodrigues, Samir Mitragotri

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 737 - 767

Опубликована: Фев. 14, 2024

Язык: Английский

Процитировано

25

Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review DOI Creative Commons
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Mohd Faizal Abdullah

и другие.

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(10), С. 105968 - 105968

Опубликована: Авг. 17, 2024

Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.

Язык: Английский

Процитировано

22

Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines DOI Creative Commons
Ujwal Havelikar,

Kabirdas B. Ghorpade,

Amit Kumar

и другие.

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Окт. 4, 2024

Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.

Язык: Английский

Процитировано

18

Polymeric nanoparticles-based targeted delivery of drugs and bioactive compounds for arthritis management DOI Creative Commons
Tanu Dixit, Anuradha Vaidya, Selvan Ravindran

и другие.

Future Science OA, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 20, 2025

This review explores the potential of polymeric nanoparticles (PNPs) as targeted drug delivery systems for arthritic treatment, overcoming limitations present therapy. A thorough literature search was conducted on databases PubMed, Scopus, and Web Science to find published articles use in treatment arthritis. includes synthesis methods, mechanisms delivery, applications PNPs. Polymeric showed excellent promise management arthritis through enhanced stability drugs, controlled sustained release, reduced systemic side effects. Some highlighted biocompatible targeting capabilities natural synthetic polymers include chitosan, hyaluronic acid, PLGA. Bioactive compounds such curcumin resveratrol delivered by PNPs therapeutic efficacy preclinical models. Despite their promise, challenges rapid clearance manufacturing scalability remain critical barriers. offer a transformative approach enabling targeted, sustained, safe delivery. Translation into clinical would thus require developments nanoparticle design, personalized medicine, scalable production techniques.

Язык: Английский

Процитировано

2

Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity DOI Open Access
Saniya Salathia, Maria Rosa Gigliobianco, Cristina Casadidio

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7286 - 7286

Опубликована: Апрель 14, 2023

The nervous and immune systems go hand in causing inflammation pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others caused by it. Macrophages play an important role modulating to trigger neuropathic Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has well-known ability bind with cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving varying molecular weight HA debated concept. HA-based drug delivery nanosystems such as nanohydrogels nanoemulsions, targeting macrophages can be used relieve pain loading antinociceptive drugs enhancing effect anti-inflammatory drugs. This review will discuss ongoing research regarding their effects.

Язык: Английский

Процитировано

36

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy DOI Creative Commons
Yedi Herdiana, Nasrul Wathoni,

Dolih Gozali

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 879 - 879

Опубликована: Март 8, 2023

Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity breast is major challenge which coupled with patient-to-patient variations heterogeneity between cells within tumor. Revolutionary drug delivery expected provide solution that challenge. Chitosan nanoparticles (CSNPs) prospects as revolutionary system capable enhancing activity reducing negative impacts normal cells. use smart systems (SDDs) delivering materials improve bioactivity NPs understand intricacies has garnered significant interest. There are many reviews about CSNPs present various points view, but they not yet described series in therapy from cell uptake death. With this description, we will more complete picture for designing preparations SDDs. This review describes SDDSs, targeting stimulus response using their mechanism. Multimodal chitosan SDDs medication therapeutic results.

Язык: Английский

Процитировано

33