International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 638, P. 122920 - 122920
Published: April 1, 2023
Language: Английский
ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041
Published: June 22, 2022
Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.
Language: Английский
Citations
131
Polymers, Journal Year: 2023, Volume and Issue: 15(15), P. 3177 - 3177
Published: July 26, 2023
The recycling of biomass into high-value-added materials requires important developments in research and technology to create a sustainable circular economy. Lignin, as component biomass, is multipurpose aromatic polymer with significant potential be used renewable bioresource many fields which it acts both promising biopolymer bioactive compound. This comprehensive review gives brief insights the recent technological trends on lignin development utilization. It divided ten main sections, starting an outlook its diversity; properties possibilities raw material for fuels, chemicals, plastics, or thermoset substitutes; new use compound nanoparticles, hydrogels, 3D-printing-based biomaterials, energy production storage. In each section are presented preparation lignin-based especially green approaches obtaining multifunctional blends bio(nano)composites; most suitable type category envisaged products; obtained materials, etc. Different application categories within various sectors, could provide completely conversion, such agriculture environment protection, food packaging, biomedicine, cosmetics, also described. medical therapeutic lignin-derived evidenced applications antimicrobial, antiviral, antitumor agents; carriers drug delivery systems controlled/targeting release; tissue engineering wound healing; coatings, natural sunscreen, surfactants. Lignin mainly fuel, and, recently, studies highlighted more bioenergy technologies, supercapacitor electrode, photocatalysts, photovoltaics.
Language: Английский
Citations
71
RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21345 - 21364
Published: Jan. 1, 2023
Nanoparticle-modified hydrogels exhibit substantial promise in the realm of wound healing, with their ability to expedite tissue regeneration, mitigate infection risks, and facilitate enhanced therapeutic outcomes.
Language: Английский
Citations
54
RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564
Published: Jan. 1, 2024
Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.
Language: Английский
Citations
42
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 737 - 767
Published: Feb. 14, 2024
Language: Английский
Citations
25
Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(10), P. 105968 - 105968
Published: Aug. 17, 2024
Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.
Language: Английский
Citations
20
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: Oct. 4, 2024
Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.
Language: Английский
Citations
18
Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 20, 2025
This review explores the potential of polymeric nanoparticles (PNPs) as targeted drug delivery systems for arthritic treatment, overcoming limitations present therapy. A thorough literature search was conducted on databases PubMed, Scopus, and Web Science to find published articles use in treatment arthritis. includes synthesis methods, mechanisms delivery, applications PNPs. Polymeric showed excellent promise management arthritis through enhanced stability drugs, controlled sustained release, reduced systemic side effects. Some highlighted biocompatible targeting capabilities natural synthetic polymers include chitosan, hyaluronic acid, PLGA. Bioactive compounds such curcumin resveratrol delivered by PNPs therapeutic efficacy preclinical models. Despite their promise, challenges rapid clearance manufacturing scalability remain critical barriers. offer a transformative approach enabling targeted, sustained, safe delivery. Translation into clinical would thus require developments nanoparticle design, personalized medicine, scalable production techniques.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7286 - 7286
Published: April 14, 2023
The nervous and immune systems go hand in causing inflammation pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others caused by it. Macrophages play an important role modulating to trigger neuropathic Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has well-known ability bind with cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving varying molecular weight HA debated concept. HA-based drug delivery nanosystems such as nanohydrogels nanoemulsions, targeting macrophages can be used relieve pain loading antinociceptive drugs enhancing effect anti-inflammatory drugs. This review will discuss ongoing research regarding their effects.
Language: Английский
Citations
36
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 879 - 879
Published: March 8, 2023
Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity breast is major challenge which coupled with patient-to-patient variations heterogeneity between cells within tumor. Revolutionary drug delivery expected provide solution that challenge. Chitosan nanoparticles (CSNPs) prospects as revolutionary system capable enhancing activity reducing negative impacts normal cells. use smart systems (SDDs) delivering materials improve bioactivity NPs understand intricacies has garnered significant interest. There are many reviews about CSNPs present various points view, but they not yet described series in therapy from cell uptake death. With this description, we will more complete picture for designing preparations SDDs. This review describes SDDSs, targeting stimulus response using their mechanism. Multimodal chitosan SDDs medication therapeutic results.
Language: Английский
Citations
32