Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
Nanomaterials,
Год журнала:
2024,
Номер
14(7), С. 646 - 646
Опубликована: Апрель 8, 2024
Dressings
with
multiple
functional
performances
(such
as
hemostasis,
promoting
regeneration,
analgesia,
and
anti-inflammatory
effects)
are
highly
desired
in
orthopedic
surgery.
Herein,
several
new
kinds
of
medicated
nanofibers
loaded
active
ingredients
for
providing
functions
were
prepared
using
the
modified
coaxial
electrospinning
processes.
With
an
electrospinnable
solution
composed
polycaprolactone
fenoprofen
core
working
fluid,
different
types
unspinnable
fluids
(including
pure
solvent,
nanosuspension
containing
tranexamic
acid
hydroxyapatite,
dilute
polymeric
comprising
acid,
polyvinylpyrrolidone)
explored
to
implement
processes
creating
multifunctional
nanofibers.
Their
morphologies
inner
structures
assessed
through
scanning
transmission
electron
microscopes,
which
all
showed
a
linear
format
without
discerned
beads
or
spindles
diameter
smaller
than
1.0
μm,
some
them
had
incomplete
core–shell
nanostructures,
represented
by
symbol
@.
Additionally,
strange
details
about
sheaths’
topographies
observed,
included
cracks,
adhesions,
embedded
nanoparticles.
XRD
FTIR
verified
that
drugs
presented
amorphous
state,
resulted
from
fine
compatibility
among
involved
components.
All
samples
demonstrated
have
hydrophilic
property
exhibited
lower
water
contact
angle
40°
300
ms.
In
vitro
dissolution
tests
indicated
was
released
sustained
manner
over
6
h
typical
Fickian
diffusion
mechanism.
Hemostatic
intentional
distribution
on
shell
sections
able
endow
rapid
hemostatic
effect
within
60
s.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(2)
Опубликована: Март 1, 2024
Core-shell
structure
is
a
concentric
circle
found
in
nature.
The
rapid
development
of
electrospinning
technology
provides
more
approaches
for
the
production
core-shell
nanofibers.
nanoscale
effects
and
expansive
specific
surface
area
nanofibers
can
facilitate
dissolution
drugs.
By
employing
ingenious
structural
designs
judicious
polymer
selection,
specialized
nanofiber
drug
delivery
systems
be
prepared
to
achieve
controlled
release.
synergistic
combination
materials
exhibits
strong
strategy
enhancing
utilization
efficiency
customizing
release
profile
Consequently,
multi-chamber
hold
great
promise
highly
efficient
disease
treatment.
However,
little
attention
concentration
focused
on
effect
In
this
review,
we
introduced
different
fabrication
techniques
nanostructures,
including
advanced
technologies
functionalization.
Subsequently,
reviewed
behaviors
their
potential
needs
comprehensive
elucidation
based
electrospun
nanostructures
could
inspire
exploration
novel
systems.
Furthermore,
once
these
fibers
with
customizable
profiles
move
toward
industrial
mass
production,
they
will
potentially
promote
pharmacy
treatment
various
diseases.
This
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
A
dressing
patch
made
of
radially
oriented
poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
(PHBV)
nanofibers
was
successfully
manufactured
with
a
modified
electrospinning
strategy.
The
as-electrospun
PHBV
nanofiber
exhibited
uniform
and
bead-free
nanofibrous
morphology
innovative
arrangement,
which
demonstrated
to
possess
obviously
improved
mechanical
property,
increased
surface
hydrophilicity
enhanced
biological
properties
compared
the
control
traditionally
randomly
pattern.
Interestingly,
it
found
that
pattern
could
induce
cell
migration
from
periphery
center
along
in
rapid
manner.
To
further
improve
biofunction
patch,
berberine
(Beri,
an
isoquinoline
alkaloid)
two
different
concentrations
were
encapsulated
into
during
electrospinning,
present
sustained
drug
release
behavior
for
nearly
one
month.
Importantly,
addition
Beri
impart
excellent
anti-inflammatory
property
by
significantly
inhibiting
secretion
pro-inflammatory
factors
M1
macrophages,
also
showed
additive
influence
on
promoting
proliferation
human
dermal
fibroblasts
(HDFs),
as
well
growth
E.
coli,
S.
aureus
C.
albicans,
Beri-free
patch.
In
animal
studies,
electrospun
loading
high
content
accelerate
healing
process
diabetic
mouse
full-thickness
skin
wound
shortened
time
(100%
closure
rate
after
18
days’
treatment)
quality
(improved
collagen
deposition,
re-epithelialization
neovascularization
hair
follicles).
all,
this
study
reported
therapeutic
strategy
integrating
physical
cues
multiple
effective
treatment
hard-to-heal
wounds.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
