Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 12, 2024
Biomaterials
are
substances
that
can
be
injected,
implanted,
or
applied
to
the
surface
of
tissues
in
biomedical
applications
and
have
ability
interact
with
biological
systems
initiate
therapeutic
responses.
Biomaterial-based
vaccine
delivery
possess
robust
packaging
capabilities,
enabling
sustained
localized
drug
release
at
target
site.
Throughout
process,
they
contribute
protecting,
stabilizing,
guiding
immunogen
while
also
serving
as
adjuvants
enhance
efficacy.
In
this
article,
we
provide
a
comprehensive
review
contributions
biomaterials
advancement
development.
We
begin
by
categorizing
biomaterial
types
properties,
detailing
their
reprocessing
strategies,
exploring
several
common
systems,
such
polymeric
nanoparticles,
lipid
hydrogels,
microneedles.
Additionally,
investigated
how
physicochemical
properties
routes
influence
immune
Notably,
delve
into
design
considerations
adjuvants,
showcasing
application
development
for
cancer,
acquired
immunodeficiency
syndrome,
influenza,
corona
virus
disease
2019
(COVID-19),
tuberculosis,
malaria,
hepatitis
B.
review,
highlight
successful
instances
where
enhanced
efficacy
discuss
limitations
future
directions
immunotherapy.
This
aims
offer
researchers
understanding
stimulate
further
progress
related
fields.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(24), P. 21391 - 21409
Published: June 7, 2023
Biofilm-associated
infections
have
emerged
as
a
significant
public
health
challenge
due
to
their
persistent
nature
and
increased
resistance
conventional
treatment
methods.
The
indiscriminate
usage
of
antibiotics
has
made
us
susceptible
range
multidrug-resistant
pathogens.
These
pathogens
show
reduced
susceptibility
intracellular
survival.
However,
current
methods
for
treating
biofilms,
such
smart
materials
targeted
drug
delivery
systems,
not
been
found
effective
in
preventing
biofilm
formation.
To
address
this
challenge,
nanotechnology
provided
innovative
solutions
formation
by
clinically
relevant
Recent
advances
nanotechnological
strategies,
including
metallic
nanoparticles,
functionalized
dendrimers,
polymeric
cyclodextrin-based
delivery,
solid
lipid
polymer
conjugates,
liposomes,
may
provide
valuable
technological
against
infectious
diseases.
Therefore,
it
is
imperative
conduct
comprehensive
review
summarize
the
recent
advancements
limitations
advanced
nanotechnologies.
present
Review
encompasses
summary
agents,
mechanisms
that
lead
formation,
impact
on
human
health.
In
nutshell,
offers
survey
managing
infections.
A
detailed
presentation
how
these
strategies
improve
control
prevent
key
objective
mechanisms,
applications,
prospects
nanotechnologies
better
understanding
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3482 - 3482
Published: July 25, 2024
Nanoparticles
are
structures
that
possess
unique
properties
with
high
surface
area-to-volume
ratio.
Their
small
size,
up
to
100
nm,
and
potential
for
modifications
have
enabled
their
use
in
a
wide
range
of
applications.
Various
factors
influence
the
applications
NPs,
including
synthesis
method
physical
attributes
such
as
size
shape.
Additionally,
materials
used
NPs
primary
determinants
application.
Based
on
chosen
material,
generally
classified
into
three
categories:
organic,
inorganic,
carbon-based.
These
categories
include
variety
materials,
proteins,
polymers,
metal
ions,
lipids
derivatives,
magnetic
minerals,
so
on.
Each
material
possesses
activity
application
NPs.
Consequently,
certain
typically
particular
areas
because
they
higher
efficiency
along
tenable
toxicity.
Therefore,
classification
base
NP
hold
significant
importance
both
research
In
this
paper,
we
discuss
these
classifications,
exemplify
most
major
categorize
them
according
preferred
area
This
review
provides
an
overall
application,
Polymers,
Journal Year:
2024,
Volume and Issue:
16(6), P. 843 - 843
Published: March 19, 2024
Chemotherapy
together
with
surgery
and/or
radiotherapy
are
the
most
common
therapeutic
methods
for
treating
cancer.
However,
off-target
effects
of
chemotherapy
known
to
produce
side
and
dose-limiting
toxicities.
Novel
delivery
platforms
based
on
natural
synthetic
polymers
enhanced
pharmacokinetic
potential
treatment
cancer
have
grown
tremendously
over
past
10
years.
Polymers
can
facilitate
selective
targeting,
enhance
prolong
circulation,
improve
delivery,
provide
controlled
release
cargos
through
various
mechanisms,
including
physical
adsorption,
chemical
conjugation,
internal
loading.
Notably,
that
biodegradable,
biocompatible,
physicochemically
stable
considered
be
ideal
carriers.
This
biomimetic
bio-inspired
system
offers
a
bright
future
effective
drug
overcome
obstacles
encountered.
review
focuses
barriers
impact
success
as
well
recent
developments
improving
Polymers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2536 - 2536
Published: Sept. 7, 2024
In
the
last
few
decades,
there
has
been
a
growing
interest
in
use
of
biodegradable
polymeric
nanoparticles
(BPNPs)
as
carriers
for
various
therapeutic
agents
drug
delivery
systems.
BPNPs
have
potential
to
improve
efficacy
numerous
active
by
facilitating
targeted
desired
site
body.
Biodegradable
polymers
are
especially
promising
nanocarriers
substances
characterized
poor
solubility,
instability,
rapid
metabolism,
and
system
elimination.
Such
molecules
can
be
efficiently
encapsulated
subsequently
released
from
nanoparticles,
which
greatly
improves
their
stability
bioavailability.
Biopolymers
seem
most
suitable
candidates
used
platforms,
due
biocompatibility
biodegradability.
Other
unique
properties
include
low
cost,
flexibility,
stability,
minimal
side
effects,
toxicity,
good
entrapment
potential,
long-term
controlled
release.
An
overview
summarizing
research
results
years
field
successful
fabrication
loaded
with
is
provided.
The
possible
challenges
involving
nanoparticle
under
physiological
conditions
possibility
scaling
up
production
while
maintaining
quality,
well
future
possibilities
employing
BPNPs,
also
reviewed.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(8), P. 672 - 672
Published: April 12, 2024
Curcumin,
an
organic
phenolic
molecule
that
is
extracted
from
the
rhizomes
of
Curcuma
longa
Linn,
has
undergone
extensive
evaluation
for
its
diverse
biological
activities
in
both
animals
and
humans.
Despite
favorable
characteristics,
curcumin
encounters
various
formulation
challenges
stability
issues
can
be
effectively
addressed
through
application
nanotechnology.
Nano-based
techniques
specifically
focused
on
enhancing
solubility,
bioavailability,
therapeutic
efficacy
while
mitigating
toxicity,
have
been
explored
curcumin.
This
review
systematically
presents
information
improvement
curcumin’s
beneficial
properties
when
incorporated,
either
individually
or
conjunction
with
other
drugs,
into
nanosystems
such
as
liposomes,
nanoemulsions,
polymeric
micelles,
dendrimers,
nanoparticles,
solid-lipid
nanostructured
lipid
carriers.
Additionally,
examines
ongoing
clinical
trials
recently
granted
patents,
offering
a
thorough
overview
dynamic
landscape
delivery.
Researchers
are
currently
exploring
nanocarriers
crucial
features
surface
modification,
substantial
loading
capacity,
biodegradability,
compatibility,
autonomous
targeting
specificity
selectivity.
Nevertheless,
utilization
delivery
still
initial
phases,
regulatory
approval
pending
persistent
safety
concerns
surrounding
their
use.
Frontiers in Nanotechnology,
Journal Year:
2024,
Volume and Issue:
6
Published: Oct. 21, 2024
Nanoparticles
are
attractive
therapeutic
tools
due
to
their
distinctive
characteristics,
including
more
accurate
drug
delivery,
improved
bioavailability,
and
enhanced
targeted
therapy.
This
review
offers
a
comprehensive
analysis
of
the
potentials
cutting-edge
nanoparticles
as
demonstrated
in
human
clinical
trials,
based
on
empirical
evidence.
Through
systematic
searches
major
scientific
databases,
relevant
studies
published
up
March
2024
were
included,
focusing
trials
utilizing
advanced
for
purposes.
The
discusses
diverse
applications
oncology,
infectious
diseases,
neurology,
other
medical
fields.
Additionally,
it
scrutinizes
safety
profiles,
efficacy
outcomes,
challenges
associated
with
nanoparticle-based
therapies.
findings
underscore
significant
progress
translating
nanoparticle
research
into
practice
highlight
potential
these
innovative
platforms
revolutionize
treatments.
contributes
valuable
insights
growing
field
therapeutics,
fostering
deeper
understanding
implications
practice.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant
growth
is
expected
to
surpass
other
significant
causes
of
death
as
one
the
top
reasons
for
dismalness
and
mortality
worldwide.
According
a
World
Health
Organization
(WHO)
study,
this
illness
approximately
between
9
10
million
instances
deaths
annually.
Chemotherapy,
radiation,
surgery
are
three
main
methods
treating
cancer.
These
seek
completely
eradicate
all
cancer
cells
while
having
fewest
possible
unintended
impacts
on
healthy
cell
types.
Owing
lack
target
selectivity,
majority
medications
have
substantial
side
effects.
On
hand,
nanomaterials
transformed
identification,
diagnosis,
management
Nanostructures
with
biomimetic
properties
been
grown
late,
fully
intent
observing
sickness.
nanostructures
be
consumed
by
in
areas
profound
disease.
Furthermore,
because
their
extraordinary
physicochemical
properties,
which
incorporate
nanoscale
aspects,
more
prominent
surface
region,
explicit
geometrical
features,
ability
embody
different
substances
within
or
outside
surfaces,
remarkable
nano-vehicles
conveying
restorative
specialists
designated
regions.
This
review
discusses
recent
developments
nanostructured
materials
such
graphene,
dendrimers,
cell-penetrating
peptide
nanoparticles,
nanoliposomes,
lipid
magnetic
nano-omics
diagnosis
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
16(1), P. 58 - 58
Published: Dec. 29, 2023
Alzheimer's
disease,
a
progressive
neurodegenerative
condition,
is
characterized
by
gradual
decline
in
cognitive
functions.
Current
treatment
approaches
primarily
involve
the
administration
of
medications
through
oral,
parenteral,
and
transdermal
routes,
aiming
to
improve
function
alleviate
symptoms.
However,
these
treatments
face
limitations,
such
as
low
bioavailability
inadequate
permeation.
Alternative
invasive
methods,
while
explored,
often
entail
discomfort
require
specialized
assistance.
Therefore,
development
non-invasive
efficient
delivery
system
crucial.
Intranasal
has
emerged
potential
solution,
although
it
constrained
unique
conditions
nasal
cavity.
An
innovative
approach
involves
use
nano-carriers
based
on
nanotechnology
for
intranasal
delivery.
This
strategy
overcome
current
limitations
providing
enhanced
bioavailability,
improved
permeation,
effective
traversal
blood-brain
barrier,
extended
retention
within
body,
precise
targeting
brain.
The
comprehensive
review
focuses
advancements
designing
various
types
nano-carriers,
including
polymeric
nanoparticles,
metal
lipid
liposomes,
nanoemulsions,
Quantum
dots,
dendrimers.
These
are
specifically
tailored
therapeutic
agents
aimed
at
combatting
disease.
In
summary,
utilization
systems
show
significant
surmounting
constraints
disease
strategies.
Nevertheless,
essential
acknowledge
regulatory
well
toxicity
concerns
associated
with
this
route;
meticulous
consideration
required
when
engineering
carrier.
underscores
revolutionize
management
highlights
importance
addressing
considerations
safe
implementations.
Embracing
could
lead
substantial
field
treatment.
