Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116713 - 116713
Опубликована: Май 11, 2024
Low
specificity
and
hypoxia-induced
drug
resistance
are
significant
challenges
in
traditional
cancer
treatment.
To
enhance
the
anticancer
efficacy,
an
injectable
hydrogel
system
is
developed
through
formation
of
dynamic
covalent
bonds
hyaluronic
acid,
allowing
for
localized
controlled
release
drugs.
This
also
utilizes
double-stranded
DNA
sequences
intercalation
delivery
chemotherapeutic
drug,
enabling
a
multifaceted
approach
to
therapy.
Cisplatin
not
only
serves
as
chemotherapy
but
acts
catalyst
chemodynamic
therapy
(CDT)
initiate
CDT
cascades
by
creating
hydrogen
peroxide
Fenton
reaction.
Hemoglobin,
enclosed
PLGA
nanoparticles,
provides
ferrous
ions
that
react
with
acidic
environment,
yielding
hydroxyl
radicals
induce
cell
death.
Additionally,
oxygen
released
from
hemoglobin
mitigates
chemoresistance,
bolstering
overall
efficacy.
Results
demonstrate
shear-thinning
properties
injectability
hydrogel.
elevates
intracellular
levels
tumor
cells,
while
efficiently
releases
generates
reactive
species
(ROS)
presence
peroxide.
In
vitro
vivo
study,
combinational
use
chemo-
therapies
achieves
synergistic
effect
on
combating
glioblastoma.
summary,
our
CDT-based
hydrogel,
activated
endogenous
cues
mediated
chemo
drugs,
spontaneously
produces
ROS
ameliorates
adverse
microenvironment
rational
selective
antitumor
strategies.
Micromachines,
Год журнала:
2023,
Номер
14(9), С. 1786 - 1786
Опубликована: Сен. 18, 2023
Exploring
bio-inspired
nanomaterials
(BINMs)
and
incorporating
them
into
micro/nanodevices
represent
a
significant
development
in
biomedical
applications.
Nanomaterials,
engineered
to
imitate
biological
structures
processes,
exhibit
distinctive
attributes
such
as
exceptional
biocompatibility,
multifunctionality,
unparalleled
versatility.
The
utilization
of
BINMs
demonstrates
potential
diverse
domains
micro/nanodevices,
encompassing
biosensors,
targeted
drug
delivery
systems,
advanced
tissue
engineering
constructs.
This
article
thoroughly
examines
the
various
BINMs,
including
those
originating
from
proteins,
DNA,
biomimetic
polymers.
Significant
attention
is
directed
toward
these
entities
subsequent
ramifications
that
arise.
review
explores
biomimicry’s
structure–function
correlations.
Synthesis
mosaics
include
bioprocesses,
biomolecules,
natural
structures.
These
nanomaterials’
interfaces
use
functionalization
geometric
adaptations,
transforming
delivery,
nanobiosensing,
organ-on-chip
cancer-on-chip
models,
wound
healing
dressing
mats,
antimicrobial
surfaces.
It
provides
an
in-depth
analysis
existing
challenges
proposes
prospective
strategies
improve
efficiency,
performance,
reliability
devices.
Furthermore,
this
study
offers
forward-thinking
viewpoint
highlighting
avenues
for
future
exploration
advancement.
objective
effectively
utilize
maximize
application
progression
thereby
propelling
rapidly
developing
field
its
promising
future.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 739 - 739
Опубликована: Фев. 5, 2024
Hyaluronan
(HA)
is
a
non-sulfated
glycosaminoglycan
that
present
in
variety
of
body
tissues
and
organs.
has
wide
range
biological
activities
are
frequently
influenced
by
molar
mass;
however,
they
also
depend
greatly
on
the
source,
purity,
kind
impurities
hyaluronan.
High-molar-mass
HA
anti-inflammatory,
immunosuppressive,
antiangiogenic
properties,
while
low-molar-mass
opposite
properties.
A
number
chemical
modifications
have
been
performed
to
enhance
stability
its
applications
medical
practice.
widely
applied
medicine,
such
as
viscosupplementation,
ophthalmology,
otolaryngology,
wound
healing,
cosmetics,
drug
delivery.
In
this
review,
we
summarized
several
polymers
based
hyaluronan
backbone.
In
recent
years,
hyaluronic
acid
(HA)
has
attracted
increasing
attention
as
a
promising
biomaterial
for
the
development
of
drug
delivery
systems.
Due
to
its
unique
properties,
such
high
biocompatibility,
low
toxicity,
and
modifiability,
HA
is
becoming
basis
creation
targeted
systems,
especially
in
field
oncology.
Receptors
overexpressed
subpopulations
cancer
cells,
one
them,
CD44,
recognized
molecular
marker
stem
cells.
This
review
examines
role
receptors
health
tumors
analyzes
existing
HA-based
systems
their
use
various
types
cancer.
The
new
will
bring
opportunities
challenges
anti-cancer
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2216 - 2216
Опубликована: Авг. 27, 2023
Polymer–drug
conjugates
(PDCs)
have
shown
great
promise
in
enhancing
the
efficacy
and
safety
of
cancer
therapy.
These
combine
advantageous
properties
both
polymers
drugs,
leading
to
improved
pharmacokinetics,
controlled
drug
release,
targeted
delivery
tumor
tissues.
This
review
provides
a
comprehensive
overview
recent
developments
PDCs
for
First,
various
types
used
these
are
discussed,
including
synthetic
polymers,
such
as
poly(↋-caprolactone)
(PCL),
D-α-tocopheryl
polyethylene
glycol
(TPGS),
(PEG),
well
natural
hyaluronic
acid
(HA).
The
choice
polymer
is
crucial
achieving
desired
properties,
stability,
biocompatibility,
release.
Subsequently,
strategies
conjugating
drugs
explored,
covalent
bonding,
which
enables
stable
linkage
between
drug,
ensuring
release
minimizing
premature
use
can
extend
circulation
time
facilitating
enhanced
accumulation
within
tissues
through
permeability
retention
(EPR)
effect.
This,
turn,
results
reduced
systemic
toxicity.
Moreover,
importance
tumor-targeting
ligands
highlighted.
Various
ligands,
antibodies,
peptides,
aptamers,
folic
acid,
herceptin,
HA,
be
incorporated
into
selectively
deliver
cells,
reducing
off-target
effects
improving
therapeutic
outcomes.
In
conclusion,
emerged
versatile
effective
approach
Their
ability
advantages
offers
delivery,
treatment,
thereby
overall
therapies.
Further
research
development
this
field
has
potential
advance
personalized
treatment
options.
Polymers,
Год журнала:
2023,
Номер
15(18), С. 3837 - 3837
Опубликована: Сен. 20, 2023
Innovation
in
biomedical
science
is
always
a
field
of
interest
for
researchers.
Drug
delivery,
being
one
the
key
areas
science,
has
gained
considerable
significance.
The
utilization
simple
yet
effective
techniques
such
as
electrospinning
undergone
significant
development
drug
delivery.
Various
polymers
PEG
(polyethylene
glycol),
PLGA
(Poly(lactic-co-glycolic
acid)),
PLA(Polylactic
acid),
and
PCA
(poly(methacrylate
citric
acid))
have
been
utilized
to
prepare
electrospinning-based
delivery
systems
(DDSs).
Polyvinyl
alcohol
(PVA)
recently
attention
because
its
biocompatibility,
biodegradability,
non-toxicity,
ideal
mechanical
properties
these
are
factors
developing
DDSs.
Moreover,
it
shown
promising
results
DDSs
individually
when
combined
with
natural
synthetic
chitosan
polycaprolactone
(PCL).
Considering
outstanding
PVA,
aim
this
review
paper
was
therefore
summarize
recent
advances
by
highlighting
potential
electrospun
PVA
systems.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
