International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141752 - 141752
Published: March 1, 2025
Language: Английский
Micromachines, Journal Year: 2023, Volume and Issue: 14(9), P. 1786 - 1786
Published: Sept. 18, 2023
Exploring bio-inspired nanomaterials (BINMs) and incorporating them into micro/nanodevices represent a significant development in biomedical applications. Nanomaterials, engineered to imitate biological structures processes, exhibit distinctive attributes such as exceptional biocompatibility, multifunctionality, unparalleled versatility. The utilization of BINMs demonstrates potential diverse domains micro/nanodevices, encompassing biosensors, targeted drug delivery systems, advanced tissue engineering constructs. This article thoroughly examines the various BINMs, including those originating from proteins, DNA, biomimetic polymers. Significant attention is directed toward these entities subsequent ramifications that arise. review explores biomimicry’s structure–function correlations. Synthesis mosaics include bioprocesses, biomolecules, natural structures. These nanomaterials’ interfaces use functionalization geometric adaptations, transforming delivery, nanobiosensing, organ-on-chip cancer-on-chip models, wound healing dressing mats, antimicrobial surfaces. It provides an in-depth analysis existing challenges proposes prospective strategies improve efficiency, performance, reliability devices. Furthermore, this study offers forward-thinking viewpoint highlighting avenues for future exploration advancement. objective effectively utilize maximize application progression thereby propelling rapidly developing field its promising future.
Language: Английский
Citations
55
Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 739 - 739
Published: Feb. 5, 2024
Hyaluronan (HA) is a non-sulfated glycosaminoglycan that present in variety of body tissues and organs. has wide range biological activities are frequently influenced by molar mass; however, they also depend greatly on the source, purity, kind impurities hyaluronan. High-molar-mass HA anti-inflammatory, immunosuppressive, antiangiogenic properties, while low-molar-mass opposite properties. A number chemical modifications have been performed to enhance stability its applications medical practice. widely applied medicine, such as viscosupplementation, ophthalmology, otolaryngology, wound healing, cosmetics, drug delivery. In this review, we summarized several polymers based hyaluronan backbone.
Language: Английский
Citations
24
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2216 - 2216
Published: Aug. 27, 2023
Polymer–drug conjugates (PDCs) have shown great promise in enhancing the efficacy and safety of cancer therapy. These combine advantageous properties both polymers drugs, leading to improved pharmacokinetics, controlled drug release, targeted delivery tumor tissues. This review provides a comprehensive overview recent developments PDCs for First, various types used these are discussed, including synthetic polymers, such as poly(↋-caprolactone) (PCL), D-α-tocopheryl polyethylene glycol (TPGS), (PEG), well natural hyaluronic acid (HA). The choice polymer is crucial achieving desired properties, stability, biocompatibility, release. Subsequently, strategies conjugating drugs explored, covalent bonding, which enables stable linkage between drug, ensuring release minimizing premature use can extend circulation time facilitating enhanced accumulation within tissues through permeability retention (EPR) effect. This, turn, results reduced systemic toxicity. Moreover, importance tumor-targeting ligands highlighted. Various ligands, antibodies, peptides, aptamers, folic acid, herceptin, HA, be incorporated into selectively deliver cells, reducing off-target effects improving therapeutic outcomes. In conclusion, emerged versatile effective approach Their ability advantages offers delivery, treatment, thereby overall therapies. Further research development this field has potential advance personalized treatment options.
Language: Английский
Citations
38
Polymers, Journal Year: 2023, Volume and Issue: 15(18), P. 3837 - 3837
Published: Sept. 20, 2023
Innovation in biomedical science is always a field of interest for researchers. Drug delivery, being one the key areas science, has gained considerable significance. The utilization simple yet effective techniques such as electrospinning undergone significant development drug delivery. Various polymers PEG (polyethylene glycol), PLGA (Poly(lactic-co-glycolic acid)), PLA(Polylactic acid), and PCA (poly(methacrylate citric acid)) have been utilized to prepare electrospinning-based delivery systems (DDSs). Polyvinyl alcohol (PVA) recently attention because its biocompatibility, biodegradability, non-toxicity, ideal mechanical properties these are factors developing DDSs. Moreover, it shown promising results DDSs individually when combined with natural synthetic chitosan polycaprolactone (PCL). Considering outstanding PVA, aim this review paper was therefore summarize recent advances by highlighting potential electrospun PVA systems.
Language: Английский
Citations
27
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129901 - 129901
Published: Feb. 3, 2024
Language: Английский
Citations
14
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132454 - 132454
Published: May 18, 2024
Language: Английский
Citations
14
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133744 - 133744
Published: July 8, 2024
Language: Английский
Citations
12
Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 61 - 61
Published: Jan. 7, 2025
In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such high biocompatibility, low toxicity, and modifiability, HA is becoming basis creation targeted systems, especially in field oncology. Receptors overexpressed subpopulations cancer cells, one them, CD44, recognized molecular marker stem cells. This review examines role receptors health tumors analyzes existing HA-based systems their use various types cancer. The new will bring opportunities challenges anti-cancer therapy.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15812 - 15812
Published: Oct. 31, 2023
Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of associated with poor prognosis in most human cancers mediates therapy resistance. For these reasons, recent years, has become a treatment target precision oncology, often via HA-conjugated antineoplastic drugs. Importantly, HA molecules different sizes have dual effect and, therefore, may enhance or attenuate the CD44-mediated signaling pathways, as they compete endogenous binding to receptors. The magnitude effects could be crucial progression, well driving inflammatory response tumor microenvironment. increasingly common use drugs HA-based compounds adjuvants treatment, adds further complexity understanding net hyaluronan-CD44 cancers. In this review, I focus on significance malignancy discuss dichotomous function hyaluronan/CD44 axis progression.
Language: Английский
Citations
20
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126581 - 126581
Published: Aug. 30, 2023
Language: Английский
Citations
19