RSM assisted phytochemical profiling of Vitex negundo and molecular docking studies of biological active compounds with target proteins DOI Creative Commons
Eti Sharma, Nisha Gaur, Sandeep Singh

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Апрель 4, 2024

Abstract Vitex negundo(Family-Verbenaceae) is a remarkable medicinal plant with numerous therapeutic applications. In this study, phytochemical screening was performed in negundoleaf extract, and extraction optimization by applying response surface methodology (RSM). Methanolic extract microwave-assisted (MAE) were found to be appropriate for obtaining the maximum yield of bioactive compounds. single-factor analysis, solvent concentration, microwave power, time variations analyzed calculate amount TPC, TFC, TAC extract. The quantity fairly obtained from 60%–95% (v/v) methanol 540 -900 W 60–90 s time. Furthermore, we also employed (RSM) optimizing negundo leaves considering three key parameters: temperature, duration. Condition at 95% methanol, 720W, 90s TPC (227.6 mg gallic acid equivalent (GAE)/g sample), TFC (978.2 RE/g (82.13 ascorbic equivalents/g sample). characterization negundowas done FTIR GC–MS identify various active groups types constituent’s presence Subsequently, compounds evaluated their bioactivity through molecular docking interactions target proteins in silico. antibacterial activity optimized studied against two Gram +ve (Bacillus sphaericus, Pectobacterium) Gram-ve (Escherichia coli, Pseudomonas aeruginosa) bacteria, inhibitory effect observed all four tested bacteria. highest shown B. sphaericus (19± 0.087) E. coli (19±0.064) followed Pectobacterium (18±0.068) Pseudomonas(13±0.093). hemolytic leaf (at dose 20µg/ml) shows minimum activity, i.e., 1.33± 0.06 %. It may concluded study that potential safe source natural antioxidants can utilized green therapeutics.

Язык: Английский

Metal and metal oxide nanoparticles combined with ionic liquids and deep eutectic solvents and their practices in drug extraction and environmental processes: A review DOI
Noureddine El Messaoudi, Funda Aydın, Youssef Miyah

и другие.

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 126955 - 126955

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

4

Towards green extraction of bioactive natural compounds DOI Creative Commons
Miguel Herrero

Analytical and Bioanalytical Chemistry, Год журнала: 2023, Номер 416(9), С. 2039 - 2047

Опубликована: Окт. 3, 2023

The increasing interest in natural bioactive compounds is pushing the development of new extraction processes that may allow their recovery from a variety different matrices and biomasses. These are clearly sought to be more environmentally friendly than conventional alternatives have traditionally been used closely related 6 principles green products. In this trend article, most critical aspects regarding current state topic described, showing lines followed make greener, illustrated by relevant examples. include implementation technologies, research on bio-based solvents, sequential process biorefinery approaches produce full valorization sources. Moreover, future outlook field presented, which main areas evolution identified discussed.

Язык: Английский

Процитировано

18

From waste to therapeutics: extraction methodologies and biological properties of bioactive compounds from fruit and vegetable waste DOI
Priyanka Roy, Valeria Graceffa

Food Bioscience, Год журнала: 2024, Номер 62, С. 105389 - 105389

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

4

Microalgal Phenolics: Systematic Review with a Focus on Methodological Assessment and Meta-Analysis DOI Creative Commons
Vasilis Andriopoulos, Michael Kornaros

Marine Drugs, Год журнала: 2024, Номер 22(10), С. 460 - 460

Опубликована: Окт. 7, 2024

A critical review and analysis of the literature relevant to phenolic content eucaryotic microalgae was performed. Several issues were identified discussed. In summary, main problems with reporting on are following: (1) despite its usefulness in determination plant samples, Folin–Ciocalteu assay is non-suitable for microalgal research due high presence interfering compounds extracts such as chlorophyll derivatives organic free aromatic amino acids or nucleotides aqueous extracts; (2) while there chromatographic evidence simple most clades, lack enzymes biosynthesis microalgae, well variability profiles even same genus, require more extensive before conclusions drawn; (3) accumulation metabolism external phenolics by has been almost universally neglected studies focusing when natural seawater complex media used cultivation process. Despite these issues, bioremediation waste streams rich through demonstrates ability those organisms adsorb, internalize, many cases oxidize transform a wide range compounds, at very concentrations. Simple found streams, olive mill waste, have shown enhance antioxidant activity various bioactivities extracts, biotransformation products also characterized. conclusion, de novo via requires further investigation better designed experiments suitable analytical methods, response their growth medium great practical interest, both terms treatment production functional foods, cosmetics, pharmaceuticals.

Язык: Английский

Процитировано

3

Green and sustainable technologies for extraction of carotenoids from natural sources: a comprehensive review DOI

Surbhi Sharma,

Anshika Dedha,

Manju M. Gupta

и другие.

Preparative Biochemistry & Biotechnology, Год журнала: 2024, Номер unknown, С. 1 - 33

Опубликована: Окт. 20, 2024

In recent years, driven by increasing consumer demand for natural and healthy convenient foods, the food industry has been shifting from synthetic to products. This shift is also reflected in growing popularity of non-conventional extraction methods pigments, which are favored sustainability environment-friendliness compared conventional processes. review aims investigate carotenoids a variety sources, including marine sources like fungus, microalgae, crustaceans, as well widely studied plants tomatoes carrots. Additionally, it delves into recovery valuable waste products pomace peels, highlighting nutritional environmental benefits. The emphasizes role green solvents such limonene, vegetable oils, ionic liquids, supercritical fluids, deep eutectic effective ecologically friendly carotenoid extraction. These technologies support ideas circular sustainable economy addition having smaller negative impact on environment. Overall, present study highlights crucial importance achieving dual goals public safety.

Язык: Английский

Процитировано

3

Extraction and Analytical Methods for the Characterization of Polyphenols in Marine Microalgae: A Review DOI Creative Commons
G. Garcı́a Bermúdez, Cristina Terenzi,

Francesca Medri

и другие.

Marine Drugs, Год журнала: 2024, Номер 22(12), С. 538 - 538

Опубликована: Ноя. 30, 2024

Marine microalgae are emerging as promising sources of polyphenols, renowned for their health-promoting benefits. Recovering polyphenols from requires suitable treatment and extraction techniques to ensure release the biomass analytical methodologies assess efficiency. This review provides a comprehensive comparison traditional cutting-edge procedures applied polyphenolic characterization in marine over past 26 years, with unique perspective on optimizing recovery identification. It addresses (I) cell disruption techniques, including bead milling, high-speed homogenization, pulsed electric field, ultrasonication, microwave, freeze-thawing, enzymatic/chemical hydrolysis; (II) such solid–liquid extraction, ultrasound microwave-assisted pressurized-liquid supercritical CO2; (III) methods, total phenolic flavonoid content assays advanced chromatographic like GC-MS, HPLC-DAD, HPLC-MS. Key findings showed milling chemical hydrolysis effective efficient HPLC-MS finest alternative precise characterization. Unlike previous reviews, this study uniquely integrates both extractive approaches one work, focusing exclusively microalgae, relatively underexplored area compared freshwater species, offering actionable insights guide future research industrial applications.

Язык: Английский

Процитировано

3

Optimization of Combined Ultrasound and Microwave-Assisted Extraction for Enhanced Bioactive Compounds Recovery from Four Medicinal Plants: Oregano, Rosemary, Hypericum, and Chamomile DOI Creative Commons

Konstantina Theodora Laina,

Christina Drosou,

Chrysanthos Stergiopoulos

и другие.

Molecules, Год журнала: 2024, Номер 29(23), С. 5773 - 5773

Опубликована: Дек. 6, 2024

This study presents the synergistic application of ultrasound- and microwave-assisted extraction (UAE-MAE) as a novel efficient method for recovering bioactive compounds from medicinal plants oregano, rosemary,

Язык: Английский

Процитировано

3

Immobilized Alcalase on ZIF-L as a Biocatalyst for Protein hydrolysis DOI Creative Commons

Hebah Al-Amodi,

Sajid Maqsood, Sulaiman Al‐Zuhair

и другие.

Resources Chemicals and Materials, Год журнала: 2025, Номер unknown, С. 100091 - 100091

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Optimization of phenolic compounds extraction and antioxidant activity from Moroccan Crocus sativus L. by-products using predictive modeling and Box-Behnken design DOI

Chaimae Slimani,

Mouhcine Fadil, Chaïmae Raïs

и другие.

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113444 - 113444

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Extraction optimization of bioactive compounds from Vitex negundo through RSM: GC–MS, FTIR, in silico analysis, and antibacterial activity DOI
Eti Sharma, Nisha Gaur, Sandeep Singh

и другие.

Journal of Plant Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0