Molecules,
Год журнала:
2025,
Номер
30(11), С. 2443 - 2443
Опубликована: Июнь 3, 2025
Andrographolide,
fucoidan,
or
a
combination
of
both
compounds
were
evaluated
to
determine
their
effects
on
the
antiviral
response
in
Atlantic
salmon
macrophage-like
cell
line
(SHK-1)
infected
with
infectious
pancreatic
necrosis
virus
(IPNV).
We
assessed
transcript
expression
levels
key
molecules
involved
interferon
(IFN)-dependent
response,
as
well
viral
load
cells
treated
these
compounds.
In
non-infected
cells,
incubation
either
andrographolide,
mixture
resulted
an
increase
IFNα1
and
various
interferon-stimulated
genes
(ISGs).
IPNV-infected
treatment
fucoidan
andrographolide
separately
did
not
significantly
enhance
compared
that
had
previously
been
contrast,
led
marked
viperin
significant
reduction
load.
Overall,
combining
greater
IPNV
than
noted
when
administered
individually.
Our
findings
suggest
pre-incubation
this
promotes
establishment
protective
state
against
IPNV,
likely
mediated
by
IFN-dependent
response.
Bioactive Materials,
Год журнала:
2022,
Номер
19, С. 458 - 473
Опубликована: Май 2, 2022
The
relationships
between
hyaluronic
acid
(HA)
and
pathological
microorganisms
incite
new
understandings
on
microbial
infection,
tissue
penetration,
disease
progression
lastly,
potential
treatments.
These
are
important
for
the
advancement
of
next
generation
antimicrobial
therapeutical
strategies
control
healthcare-associated
infections.
Herein,
this
review
will
focus
interplay
HA,
bacteria,
fungi,
viruses.
This
also
comprehensively
detail
discuss
activity
displayed
by
various
HA
molecular
weights
a
variety
biomedical
pharmaceutical
applications,
including
microbiology,
pharmaceutics,
engineering.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Дек. 6, 2022
The
potential
of
edible
mushrooms
as
an
unexploited
treasure
trove,
although
rarely
included
in
known
food
guidelines,
is
highlighted.
Their
role
shielding
people
against
the
side
effects
unhealthy
stylish
diet
reviewed.
Mushrooms
complement
human
with
various
bioactive
molecules
not
identified
or
deficient
foodstuffs
plant
and
animal
sources,
being
considered
a
functional
for
prevention
several
diseases.
have
been
widely
used
medicinal
products
more
than
2,000
years,
but
globally
field
use
wild
has
untapped.
There
broad
range
which
remain
poorly
even
unreported
valuable
pool
sources
compounds
biopharma
utilization
new
dietary
supplements.
Some
unique
elements
their
preventative
healthcare
are
emphasized,
through
positive
impact
on
immune
system.
antiviral,
anti-inflammatory,
anti-neoplastic,
other
health
concerns
discussed.
incorporate
top
non-digestible
oligosaccharides,
ergothioneine,
humans
unable
to
synthesize,
later
antioxidant,
cytoprotective,
anti-inflammatory
element,
therapeutic
potential,
approved
by
world
agencies.
prebiotic
activity
beneficially
affects
gut
homeostasis
performance
balance
microbiota
enhanced.
Several
recent
studies
neurological
contribution
growth
nerve
brain
cells
mentioned.
Indeed,
foods'
nutraceuticals
presently
regarded
next-generation
foods,
supporting
wellness,
promising
prophylactic
agents.
Plants,
Год журнала:
2022,
Номер
11(24), С. 3449 - 3449
Опубликована: Дек. 9, 2022
Plant
viral
diseases
are
major
constraints
causing
significant
yield
losses
worldwide
in
agricultural
and
horticultural
crops.
The
commonly
used
methods
cannot
eliminate
load
infected
plants.
Many
unconventional
presently
being
employed
to
prevent
infection;
however,
every
time,
these
not
found
promising.
As
a
result,
it
is
critical
identify
the
most
promising
sustainable
management
strategies
for
economically
important
plant
diseases.
genetic
makeup
of
90
percent
constitutes
single-stranded
RNA;
way
any
RNA
viruses
through
use
ribonucleases.
scope
involving
beneficial
microbial
organisms
integrated
utmost
importance
highly
imperative.
This
review
highlights
prokaryotic
growth-promoting
rhizobacteria/endophytic
bacteria,
actinomycetes,
fungal
organisms,
as
well
their
possible
mechanisms
suppressing
infection
plants
via
cross-protection,
ISR,
accumulation
defensive
enzymes,
phenolic
compounds,
lipopeptides,
protease,
RNase
activity
against
virus
infection.
Molecular Systems Design & Engineering,
Год журнала:
2024,
Номер
9(10), С. 977 - 999
Опубликована: Янв. 1, 2024
Complex
multilayered
tissues
have
been
regenerated
by
extrusion-based
3D
bioprinting
with
biocompatible
polymers.
Multilayer
fabrications
tissue-specific
bioinks
are
possible
controlling
gel
properties
including
interaction
between
layers.
Molecules,
Год журнала:
2022,
Номер
27(20), С. 7140 - 7140
Опубликована: Окт. 21, 2022
Pleurotus
eryngii
(PE)
is
an
edible
mushroom
with
high
nutritional
value.
polysaccharides
(PEPs)
are
one
of
the
main
active
ingredients
and
manifest
a
great
variety
biological
activities.
This
study
mainly
focused
on
chemical
characterization
activities
PEPs,
which
were
separated
into
two
fractions
(named
WPS
P-1).
dominated
by
β-glycosidic
bonds
contains
α-glycosidic
bonds,
P-1
only
bonds.
The
molecular
weights
4.5
×
105
Da
2.2
104
Da.
result
GC
indicated
that
composed
rhamnose,
arabinose,
xylose,
mannose,
glucose,
galactose,
ratio
0.35:0.24:0.45:0.24:28.78:1.10
for
0.95:0.64:0.66:1.84:60.69:0.67
P-1.
advanced
structure
studies
had
no
triple-helical
structure,
where
dense
loose
structure.
In
addition,
antioxidant
activity
surpassed
P-1,
also
exhibited
hypoglycemic
via
inhibiting
α-glycosidase
promoting
expression
PI3K-AKT
signaling
pathway
based
in
vitro
assay
cell
experiments.
