Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications?

Bioactive Materials, Journal Year: 2022, Volume and Issue: 19, P. 458 - 473

Published: May 2, 2022

The relationships between hyaluronic acid (HA) and pathological microorganisms incite new understandings on microbial infection, tissue penetration, disease progression lastly, potential treatments. These are important for the advancement of next generation antimicrobial therapeutical strategies control healthcare-associated infections. Herein, this review will focus interplay HA, bacteria, fungi, viruses. This also comprehensively detail discuss activity displayed by various HA molecular weights a variety biomedical pharmaceutical applications, including microbiology, pharmaceutics, engineering.

Language: Английский

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Mushrooms as future generation healthy foods

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 6, 2022

The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role shielding people against the side effects unhealthy stylish diet reviewed. Mushrooms complement human with various bioactive molecules not identified or deficient foodstuffs plant and animal sources, being considered a functional for prevention several diseases. have been widely used medicinal products more than 2,000 years, but globally field use wild has untapped. There broad range which remain poorly even unreported valuable pool sources compounds biopharma utilization new dietary supplements. Some unique elements their preventative healthcare are emphasized, through positive impact on immune system. antiviral, anti-inflammatory, anti-neoplastic, other health concerns discussed. incorporate top non-digestible oligosaccharides, ergothioneine, humans unable to synthesize, later antioxidant, cytoprotective, anti-inflammatory element, therapeutic potential, approved by world agencies. prebiotic activity beneficially affects gut homeostasis performance balance microbiota enhanced. Several recent studies neurological contribution growth nerve brain cells mentioned. Indeed, foods' nutraceuticals presently regarded next-generation foods, supporting wellness, promising prophylactic agents.

Language: Английский

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Microbial protein sources: A comprehensive review on the potential usage of fungi and cyanobacteria in sustainable food systems

Food and Humanity, Journal Year: 2024, Volume and Issue: 3, P. 100366 - 100366

Published: July 27, 2024

Language: Английский

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Mechanistic insights into the nutritional and therapeutic potential of Spirulina (Arthrospira) spp.: Challenges and opportunities

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 151, P. 104648 - 104648

Published: July 24, 2024

Language: Английский

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Recent advances in Platycodon grandiflorum polysaccharides: Preparation techniques, structural features, and bioactivities

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129047 - 129047

Published: Jan. 1, 2024

Language: Английский

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Mechanisms of Microbial Plant Protection and Control of Plant Viruses

Plants, Journal Year: 2022, Volume and Issue: 11(24), P. 3449 - 3449

Published: Dec. 9, 2022

Plant viral diseases are major constraints causing significant yield losses worldwide in agricultural and horticultural crops. The commonly used methods cannot eliminate load infected plants. Many unconventional presently being employed to prevent infection; however, every time, these not found promising. As a result, it is critical identify the most promising sustainable management strategies for economically important plant diseases. genetic makeup of 90 percent constitutes single-stranded RNA; way any RNA viruses through use ribonucleases. scope involving beneficial microbial organisms integrated utmost importance highly imperative. This review highlights prokaryotic growth-promoting rhizobacteria/endophytic bacteria, actinomycetes, fungal organisms, as well their possible mechanisms suppressing infection plants via cross-protection, ISR, accumulation defensive enzymes, phenolic compounds, lipopeptides, protease, RNase activity against virus infection.

Language: Английский

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A concise review of the highly diverse genus Sargassum C. Agardh with wide industrial potential

Journal of Applied Phycology, Journal Year: 2023, Volume and Issue: 35(4), P. 1453 - 1483

Published: May 15, 2023

Language: Английский

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Isolation, Structural Characterization, and Hypoglycemic Activities In Vitro of Polysaccharides from Pleurotus eryngii

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7140 - 7140

Published: Oct. 21, 2022

Pleurotus eryngii (PE) is an edible mushroom with high nutritional value. polysaccharides (PEPs) are one of the main active ingredients and manifest a great variety biological activities. This study mainly focused on chemical characterization activities PEPs, which were separated into two fractions (named WPS P-1). dominated by β-glycosidic bonds contains α-glycosidic bonds, P-1 only bonds. The molecular weights 4.5 × 105 Da 2.2 104 Da. result GC indicated that composed rhamnose, arabinose, xylose, mannose, glucose, galactose, ratio 0.35:0.24:0.45:0.24:28.78:1.10 for 0.95:0.64:0.66:1.84:60.69:0.67 P-1. advanced structure studies had no triple-helical structure, where dense loose structure. In addition, antioxidant activity surpassed P-1, also exhibited hypoglycemic via inhibiting α-glycosidase promoting expression PI3K-AKT signaling pathway based in vitro assay cell experiments.

Language: Английский

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Hyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 341 - 362

Published: Dec. 25, 2024

Acyclovir (ACV) is a potentially effective antiviral medication; however, it has serious drawback, which its poor solubility, bioavailability, and short half-life. The goal of this study to improve drawbacks through the synthesis nanogels. In study, cross-linked hyaluronic acid-grafted poly(acrylamide-co-itaconic acid) nanogel synthesized successfully free radical polymerization used as safe pH-responsive carrier for ACV. nanogels showed pH response in vitro vivo. prepared C5 (1:1 ratio acrylamide: itaconic), had highest grafting efficiency, maximum swelling, drug loading, release 7.4, higher than 1.2. Also, C5, large surface area, good stability, matrices shrank acidic medium protected drug, while basic medium, expanded released ACV sustained manner improved bioavailability half-life

Language: Английский

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In vitro and in vivo antimalarial activity of green synthesized silver nanoparticles using Sargassum tenerrimum - a marine seaweed

Acta Tropica, Journal Year: 2023, Volume and Issue: 245, P. 106982 - 106982

Published: July 3, 2023

Language: Английский

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