eXPRESS Polymer Letters,
Год журнала:
2023,
Номер
18(2), С. 160 - 192
Опубликована: Дек. 6, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
a
remarkable
capacity
to
absorb
substantial
amounts
of
water
and
biological
fluids,
rendering
them
highly
attractive
for
drug
delivery
applications.The
COVID-19
pandemic
has
acted
as
catalyst
research
innovation
in
the
realm
polymer-based
delivery,
particular
emphasis
on
antiviral
therapeutics,
vaccines,
diagnostics,
precision
respiratory
system.The
distinctive
attributes
hydrogels,
such
their
biocompatibility,
customizable
release
profiles,
ease
functionalization,
establish
versatile
platforms
development
advanced
systems
combat
not
only
but
also
spectrum
other
infectious
diseases.This
study
is
dedicated
scruti-nizing
evaluating
characteristics
employed
treatment
diseases
associated
SARS-CoV-2
virus.Furthermore,
investigation
introduces
novel
classification
system
deployed
SARS-CoV-2-related
diseases.Additionally,
paper
provides
an
up-to-date
evaluation
latest
developed
utilized
dis-eases
linked
virus,
based
conducted
through
recent
months
2023.
Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2361 - 2361
Опубликована: Сен. 21, 2023
Nanoformulations
have
become
increasingly
useful
as
drug
delivery
technologies
in
recent
decades.
As
therapeutics,
oral
administration
is
the
most
common
method,
although
it
not
always
effective
route
because
of
challenges
with
swallowing,
gastrointestinal
discomfort,
low
solubility,
and
poor
absorption.
One
significant
barriers
that
medications
must
overcome
to
exert
a
therapeutic
effect
impact
first
hepatic
transit.
Studies
shown
controlled-release
systems
using
nanoparticles
composed
biodegradable
natural
polymers
significantly
improve
administration,
which
why
these
materials
attracted
attention.
Chitosan
possesses
wide
variety
properties
functions
pharmaceutical
well
healthcare
industries.
Drug
encapsulation
transport
within
body
are
two
its
important
features.
Moreover,
chitosan
can
enhance
efficacy
by
facilitating
interaction
target
cells.
Based
on
physicochemical
properties,
potentially
be
synthesized
into
nanoparticles,
this
review
summarizes
advances
applications
orally
delivered
nanoparticle
interventions.
Viral
infections
continue
to
threaten
human
health.
It
remains
a
major
challenge
efficiently
inhibit
viral
infection
while
avoiding
secondary
injury.
Here,
we
designed
multifunctional
nanoplatform
(termed
as
ODCM),
prepared
by
oseltamivir
phosphate
(OP)-loaded
polydopamine
(PDA)
nanoparticles
camouflaged
the
macrophage
cell
membrane
(CM).
OP
can
be
loaded
onto
PDA
through
π-π
stacking
and
hydrogen
bonding
interactions
with
high
drug-loading
rate
of
37.6%.
In
particular,
biomimetic
accumulate
actively
in
damaged
lung
model
infection.
At
site,
consume
excess
reactive
oxygen
species
simultaneously
oxidized
degraded
achieve
controlled
release
OP.
This
system
exhibits
enhanced
delivery
efficiency,
inflammatory
storm
suppression,
replication
inhibition.
Therefore,
exerts
outstanding
therapeutic
effects
improving
pulmonary
edema
protecting
injury
mouse
influenza
A
virus
Polymers,
Год журнала:
2023,
Номер
15(18), С. 3849 - 3849
Опубликована: Сен. 21, 2023
The
evolution
of
respiratory
diseases
represents
a
considerable
public
health
challenge,
as
they
are
among
the
leading
causes
death
worldwide.
In
this
sense,
in
addition
to
high
prevalence
such
asthma,
chronic
obstructive
pulmonary
disease,
pneumonia,
cystic
fibrosis,
and
lung
cancer,
emerging
diseases,
particularly
those
caused
by
members
coronavirus
family,
have
contributed
significant
number
deaths
on
global
scale
over
last
two
decades.
Therefore,
several
studies
been
conducted
optimize
efficacy
treatments
against
these
focusing
drug
delivery
using
nanomedicine.
Thus,
development
nanocarriers
has
emerged
promising
alternative
overcome
limitations
conventional
therapy,
increasing
bioavailability
at
target
site
reducing
unwanted
side
effects.
context,
nanoparticles
composed
chitosan
(CS)
show
advantages
other
because
possesses
intrinsic
biological
properties,
anti-inflammatory,
antimicrobial,
mucoadhesive
capacity.
Moreover,
CS
potential
enhance
stability,
prolong
duration
action,
improve
targeting,
control
release,
dissolution
poorly
soluble
drugs,
increase
cell
membrane
permeability
hydrophobic
drugs.
These
properties
could
performance
after
its
administration.
review
aims
discuss
for
delivery,
highlighting
how
their
can
treatment
including
synergistic
action
with
encapsulated
drug.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(3), С. 1336 - 1361
Опубликована: Фев. 27, 2024
Over
the
past
decade,
nanotechnology
has
seen
extensive
integration
into
biomedical
applications,
playing
a
crucial
role
in
biodetection,
drug
delivery,
and
diagnostic
imaging.
This
is
especially
important
reproductive
health
care,
which
become
an
emerging
significant
area
of
research.
Global
concerns
have
intensified
around
disorders
such
as
infertility,
endometriosis,
ectopic
pregnancy,
erectile
dysfunction,
benign
prostate
hyperplasia,
sexually
transmitted
infections,
cancers.
Nanotechnology
presents
promising
solutions
to
address
these
by
introducing
innovative
tools
techniques,
facilitating
early
detection,
targeted
improved
imaging
capabilities.
Through
utilization
nanoscale
materials
devices,
researchers
can
craft
treatments
that
are
not
only
more
precise
but
also
effective,
significantly
enhancing
outcomes
healthcare.
Looking
forward,
future
medicine
holds
immense
potential
for
reshaping
diagnostics,
personalized
therapies,
fertility
preservation.
The
nanotechnology-driven
delivery
systems
anticipated
elevate
treatment
effectiveness,
minimize
side
effects,
offer
patients
therapies
efficient.
review
aims
delve
various
types,
properties,
preparation
techniques
nanocarriers
specifically
designed
context
disorders,
shedding
light
on
current
landscape
directions
this
dynamic
field.
Abstract
Viral
infections
in
humans
are
responsible
for
fatalities
worldwide
and
contribute
to
the
incidence
of
various
human
ailments.
Controllable
targeted
medicine
delivery
against
many
illnesses,
including
viral
infection,
may
be
significantly
aided
by
using
bacteria
bacteria-derived
products.
They
accumulate
diseased
tissues
despite
physical
obstacles,
where
they
can
launch
antiviral
immunity.
The
ability
genetically
chemically
modify
them
means
that
vaccinations
manufactured
delivered
affected
more
safely
effectively.
objective
this
study
is
provide
an
overview
latest
advancements
field
utilizing
bacterial
derivatives
as
carriers
administering
medication
treat
diseases
such
SARS-CoV-2,
hepatitis
B
virus,
C
immunodeficiency
papillomavirus,
influenza,
Ebola
virus.
Graphical
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 21, 2024
Antibiotic
resistance
is
a
pressing
global
health
challenge,
and
polymyxins
have
emerged
as
the
last
line
of
defense
against
multidrug-resistant
Gram-negative
(MDR-GRN)
bacterial
infections.
Despite
longstanding
utility
colistin,
complexities
surrounding
in
terms
mechanisms
pharmacological
properties
warrant
critical
attention.
This
review
consolidates
current
literature,
focusing
on
antibacterial
mechanisms,
pathways,
innovative
strategies
to
mitigate
resistance.
We
are
also
investigating
pharmacokinetics
elucidate
factors
that
influence
their
