DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers DOI Creative Commons
Samuel Carleial, Daniel Nätt,

Eva Unternährer

и другие.

Scientific Reports, Год журнала: 2021, Номер 11(1)

Опубликована: Сен. 16, 2021

Abstract The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum affliction psychological social realm. Can psychotherapy reorganise these memories through changes DNA methylation signatures? Using randomised controlled parallel group design, we examined methylome-wide saliva samples 84 female former child soldiers from Eastern DR Congo before six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM , RIPOR2 AFAP1 MOCOS . In addition, treatment associations overlapped at gene level with baseline clinical outcomes. DMPs are involved memory formation—the key agent trauma focused treatments—and enriched for molecular pathways commonly affected by disorders. Results were partially replicated an independent sample 53 Northern Uganda. Our results suggest impact women war-related childhood trauma. Trial registration : Addressing Heightened Levels Aggression Traumatized Offenders With Psychotherapeutic Means (ClinicalTrials.gov Identifier: NCT02992561, 14/12/2016).

Язык: Английский

Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan DOI Creative Commons
Julia Herzog, Christian Schmahl

Frontiers in Psychiatry, Год журнала: 2018, Номер 9

Опубликована: Сен. 4, 2018

Introduction: Adverse childhood experiences (ACE) such as sexual and physical abuse or neglect are frequent in constitute a massive stressor with long-lasting adverse effects on the brain, mental health. The aim of this qualitative review is to present concise overview literature impact ACE neurobiology, somatic health later adulthood. Methods: authors reviewed existing adulthood summarized results for overview. Results: In adulthood, history can result complex clinical profiles several co-occurring disorders posttraumatic stress disorder, depression, borderline personality obesity diabetes. Although general effect development neural alterations be assumed, role type timing particular interest terms prevention treatment ACE-related conditions. It has been suggested that during certain vulnerable developmental phases risk subsequent increased. Moreover, emerging evidence points sensitive periods specificity ACE-subtypes neurobiological alterations, e.g., volumetric functional changes amygdala hippocampus. Conclusion: Longitudinal studies needed investigate characteristics mechanisms relevant by integrating state art knowledge methods. By identifying validating psychosocial factors diagnostic markers one might improve innovative psychological options individuals suffering from disorders.

Язык: Английский

Процитировано

446
Type and timing of adverse childhood experiences differentially affect severity of PTSD, dissociative and depressive symptoms in adult inpatients DOI Creative Commons
Inga Schalinski, Martin H. Teicher, Daniel Nischk

и другие.

BMC Psychiatry, Год журнала: 2016, Номер 16(1)

Опубликована: Авг. 19, 2016

A dose-dependent effect of Adverse Childhood Experiences (ACE) on the course and severity psychiatric disorders has been frequently reported. Recent evidence indicates additional impact type timing distinct ACE symptom experienced in adulthood, support stress-sensitive periods (brain) development. The present study seeks to clarify symptoms that are often comorbid across various diagnostic groups: posttraumatic stress disorder (PTSD), shutdown dissociation depression. key aim was determine compare importance versus specific prediction levels.Exposure ten types maltreatment up age 18 were retrospectively assessed N = 129 inpatients using Maltreatment Abuse Chronology Exposure (MACE). Symptoms PTSD, dissociation, depression related ACE. predictive power peak timings compared global MACE measures duration, multiplicity overall severity.A (MACE severity) all confirmed earlier findings. Conditioned random forest regression verified PTSD best predicted by severity, whereas effects showed stronger for In particular, physical neglect at 5 emotional ages 4-5 increased 8-9 enhanced depression.In sensitive period exposure model, results indicate augmented vulnerability x ACE, particular emphasizing pre-school (age 4-5) pre-adolescent (8-9) as neglect. most severe stress-related disorder, varies with amount adverse experiences irrespective experience. Considering improves understanding vulnerability, should inform diagnostics psychopathology like adult patients.

Язык: Английский

Процитировано

265
Post-traumatic stress disorder in a sample of Syrian refugees in Lebanon DOI
François Kazour,

Nada Zahreddine,

Michel Maragel

и другие.

Comprehensive Psychiatry, Год журнала: 2016, Номер 72, С. 41 - 47

Опубликована: Сен. 24, 2016

Язык: Английский

Процитировано

180
Neuropsychological functioning of childhood trauma and post-traumatic stress disorder: A meta-analysis DOI
Stephanie Malarbi, Hisham M. Abu‐Rayya,

Frank Muscara

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2016, Номер 72, С. 68 - 86

Опубликована: Ноя. 13, 2016

Язык: Английский

Процитировано

146
Endocannabinoid concentrations in hair are associated with PTSD symptom severity DOI
Sarah Wilker,

Anett Pfeiffer,

Thomas Elbert

и другие.

Psychoneuroendocrinology, Год журнала: 2016, Номер 67, С. 198 - 206

Опубликована: Фев. 13, 2016

Язык: Английский

Процитировано

107
Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress DOI

Christina Boeck,

Alexandra M. Koenig,

Katharina Schury

и другие.

Mitochondrion, Год журнала: 2016, Номер 30, С. 197 - 207

Опубликована: Авг. 15, 2016

Язык: Английский

Процитировано

107
Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience DOI
Immanuel Elbau, Cristiana Cruceanu, Elisabeth B. Binder

и другие.

Biological Psychiatry, Год журнала: 2019, Номер 86(6), С. 433 - 442

Опубликована: Май 2, 2019

Язык: Английский

Процитировано

91
The Influence of Adverse Childhood Experiences in Pain Management: Mechanisms, Processes, and Trauma-Informed Care DOI Creative Commons
Lydia V. Tidmarsh, Richard Harrison, Deepak Ravindran

и другие.

Frontiers in Pain Research, Год журнала: 2022, Номер 3

Опубликована: Июнь 10, 2022

Adverse childhood experiences (ACEs) increase the likelihood of reduced physical and psychological health in adulthood. Though understanding management traumatic is growing, empirical exploration ACEs clinical outcomes remains under-represented under-explored. This topical review aimed to highlight role experience chronic pain, pain services decision making by: ( 1 ) providing an overview relationship between pain; 2 identifying biopsychosocial mechanisms through which may risk persistent 3 highlighting impact on patient adherence completion treatment; 4 practical implications for management. Review findings demonstrated that are associated with increased complications, catastrophizing depression combination these factors further heightens early treatment attrition. The pervasive detrimental impacts COVID-19 pandemic their cyclical effects discussed context decline during long waitlists. highlights how people can be supported by maintaining trauma-informed practices acknowledging outcomes. Clinicians who ACE-informed have potential minimize negative influence outcomes, ultimately optimizing services.

Язык: Английский

Процитировано

48
Gender differences in response to war-related trauma and posttraumatic stress disorder – a study among the Congolese refugees in Uganda DOI Creative Commons
Herbert E. Ainamani, Thomas Elbert,

David Kani Olema

и другие.

BMC Psychiatry, Год журнала: 2020, Номер 20(1)

Опубликована: Янв. 10, 2020

The wars in the Democratic Republic of Congo have left indelible marks on mental health and functioning Congolese civilians that sought refuge Uganda. Even though it is clear who are exposed to potentially traumatizing events war conflict areas develop trauma-related problems, scholarly information gender differences exposure different war-related traumatic events, their conditional risks developing PTSD whether cumulative affects men women differently still scanty.In total, 325 (n = 143 males, n 182 females) refugees lived Nakivale, a refugee settlement Southwestern part Uganda were interviewed within year after arrival. Assessment included DSM-IV symptom severity.Our main findings highly with experiencing dangerous flight as most common event for both (97%) (97%). overall high prevalence differed among (94%) (84%). highest was associated rape. dose-response effect significantly between showing higher severity when low moderate levels types.In areas, types expose them symptoms, particularly women. Interventions focused at reducing problems resulting from should take context into consideration.

Язык: Английский

Процитировано

55
Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy DOI Creative Commons
Sarah Wilker, Vanja Vukojević, Anna Schneider

и другие.

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Янв. 19, 2023

Abstract Epigenetic processes allow plasticity in gene regulation response to significant environmental events. Accumulating evidence suggests that effective psychotherapy is accompanied by epigenetic changes, rendering DNA methylation a potential biomarker of therapy success. Due the central role glucocorticoid dynamics stress and alteration aversive memories, receptors are likely involved molecular required successfully treat Posttraumatic Stress Disorder (PTSD). This study aimed investigate relationship between at receptor ( NR3C1 ) PTSD treatment success evidence-based psychotherapy. A sample N = 153 conflict survivors from Northern Uganda (98 females 55 males) with were treated Narrative Exposure Therapy (NET). Diagnostic interviews saliva sampling took place pretreatment 4 10 months after completion. We investigated associations symptom development changes 38 CpG sites spanning over three times measurement using repeated measures correlation. After accounting for multiple comparisons, site cg25535999 remained negatively associated symptoms. These results followed up mixed models as well structural equation modelling. analyses revealed responders had increase NET. Furthermore, lower predicted higher improvement. Our suggest different profile compared non-responders underscore signaling trauma-focused therapy.

Язык: Английский

Процитировано

19