Antibiotics,
Год журнала:
2023,
Номер
12(10), С. 1539 - 1539
Опубликована: Окт. 14, 2023
Acinetobacter
baumannii
is
a
nosocomial
pathogen
known
for
its
ability
to
form
biofilms,
leading
persistent
infections
and
antibiotic
resistance.
The
limited
effective
antibiotics
have
encouraged
the
development
of
innovative
strategies
such
as
using
essential
oils
their
constituents.
This
study
evaluated
efficacy
oregano
(Lippia
graveolens)
oil
(OEO)
terpene
compounds,
carvacrol
thymol,
in
inhibiting
A.
biofilms.
These
treatments
showed
minimum
inhibitory
concentration
0.6,
0.3,
2.5
mg/mL
bactericidal
1.2,
5
mg/mL,
respectively.
Sub-inhibitory
doses
each
treatment
OEO
significantly
reduced
biofilm
biomass
covered
area
biofilms
measured
by
fluorescence
microscopy.
Carvacrol
at
0.15
exhibited
most
potent
efficacy,
achieving
remarkable
95%
reduction.
concentrations
formation
stainless
steel
surfaces
up
1.15
log
CFU/cm2
compared
untreated
bacteria.
thymol
reductions
0.6
0.4
CFU/cm2,
respectively,
without
affecting
cell
viability.
Moreover,
terpenes
inhibited
twitching
motility,
crucial
step
establishment,
with
exhibiting
highest
inhibition,
followed
thymol.
provides
valuable
insights
into
potential
agents
against
offering
promising
avenues
developing
novel
prevent
overcome
Microorganisms,
Год журнала:
2023,
Номер
11(6), С. 1614 - 1614
Опубликована: Июнь 19, 2023
Biofilm
is
complex
and
consists
of
bacterial
colonies
that
reside
in
an
exopolysaccharide
matrix
attaches
to
foreign
surfaces
a
living
organism.
frequently
leads
nosocomial,
chronic
infections
clinical
settings.
Since
the
bacteria
biofilm
have
developed
antibiotic
resistance,
using
antibiotics
alone
treat
brought
on
by
ineffective.
This
review
provides
succinct
summary
theories
behind
composition
of,
formation
drug-resistant
attributed
cutting-edge
curative
approaches
counteract
biofilm.
The
high
frequency
medical
device-induced
due
warrants
application
innovative
technologies
manage
complexities
presented
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2655 - 2655
Опубликована: Фев. 24, 2024
One
of
the
key
mechanisms
enabling
bacterial
cells
to
create
biofilms
and
regulate
crucial
life
functions
in
a
global
highly
synchronized
way
is
communication
system
called
quorum
sensing
(QS).
QS
cell-to-cell
process
that
depends
on
population
density
mediated
by
small
signalling
molecules
autoinducers
(AIs).
In
bacteria,
controls
biofilm
formation
through
regulation
gene
expression
involved
extracellular
polymeric
matrix
(EPS)
synthesis,
virulence
factor
production,
stress
tolerance
metabolic
adaptation.
Forming
one
antimicrobial
resistance
(AMR).
A
common
feature
human
pathogens
ability
form
biofilm,
which
poses
serious
medical
issue
due
their
high
susceptibility
traditional
antibiotics.
Because
associated
with
formation,
there
belief
inhibition
activity
quenching
(QQ)
may
provide
alternative
therapeutic
methods
for
treating
microbial
infections.
This
review
summarises
recent
progress
research,
focusing
biofilms,
especially
those
formed
pathogenic
become
resistant
antibiotic
treatment.
Subsequently,
potential
approach
highlighting
innovative
non-antibiotic
strategies
control
AMR
bacteria
has
been
discussed.
Abstract
Bacterial
infections
are
a
significant
obstacle
to
the
healing
of
acute
and
chronic
wounds,
such
as
diabetic
ulcers
burn
injuries.
Traditional
antibiotics
primary
treatment
for
bacterial
infections,
but
they
present
issues
antibiotic
resistance,
limited
efficacy,
potential
side
effects.
This
challenge
leads
exploration
nanozymes
alternative
therapeutic
agents.
Nanozymes
nanomaterials
with
enzyme‐like
activities.
Owing
their
low
production
costs,
high
stability,
scalability,
multifunctionality,
have
emerged
prominent
focus
in
antimicrobial
research.
Among
various
types
nanozymes,
metal‐based
offer
several
benefits,
including
broad‐spectrum
activity
robust
catalytic
properties.
Specifically,
copper‐based
(CuNZs)
shown
considerable
promoting
wound
healing.
They
exhibit
strong
effects,
reduce
inflammation,
enhance
tissue
regeneration,
making
them
highly
advantageous
use
care.
review
describes
dual
functions
CuNZs
combating
infection
facilitating
repair.
Recent
advancements
design
synthesis
CuNZs,
evaluating
promotion,
biosafety
both
vitro
vivo
on
basis
core
components,
critically
important.
Marine Drugs,
Год журнала:
2023,
Номер
21(5), С. 313 - 313
Опубликована: Май 20, 2023
The
eradication
of
bacterial
biofilm
represents
a
crucial
strategy
to
prevent
clinical
problem
associated
with
microbial
persistent
infection.
In
this
study
we
evaluated
the
ability
exopolysaccharide
(EPS)
B3-15,
produced
by
marine
Bacillus
licheniformis
adhesion
and
formation
Pseudomonas
aeruginosa
ATCC
27853
Staphylococcus
aureus
29213
on
polystyrene
polyvinyl
chloride
surfaces.
EPS
was
added
at
different
times
(0,
2,
4
8
h),
corresponding
initial,
reversible
irreversible
attachment,
after
development
(24
or
48
h).
(300
µg/mL)
impaired
initial
phase,
preventing
even
when
2
h
incubation,
but
had
no
effects
mature
biofilms.
Without
exerting
any
antibiotic
activity,
antibiofilm
mechanisms
were
related
modification
(i)
abiotic
surface
properties,
(ii)
cell-surface
charges
hydrophobicity,
iii)
cell-to-cell
aggregation.
addition
downregulated
expression
genes
(lecA
pslA
P.
clfA
S.
aureus)
involved
in
adhesion.
Moreover,
reduced
(five
logs-scale)
(one
log)
human
nasal
epithelial
cells.
could
represent
promising
tool
for
prevention
biofilm-related
infections.
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(4), С. 133 - 133
Опубликована: Март 29, 2024
Biofilms,
which
consist
of
microorganisms
enclosed
in
an
extracellular
polymeric
material
(EPS),
hold
immense
importance
the
fields
environmental
research,
industry,
and
medicine.
They
play
a
significant
role
ecosystem
dynamics
stability,
but
they
also
pose
issues
such
as
biofouling,
corrosion,
pollution.
Biofilms
medical
environments
are
linked
to
persistent
infections
elevated
healthcare
expenses.
The
EPS
matrix
plays
crucial
maintaining
structural
integrity
antibiotic
resistance
these
structures.
research
primarily
investigates
facilitating
horizontal
gene
transfer
among
biofilm
communities,
with
particular
emphasis
on
its
impact
this
process.
process
is
recognized
pivotal
mechanism
emergence
resistance,
underscoring
function
biofilms.
analysis
highlights
financial
constraints
caused
by
biofilms
several
industries.
Biofilm-associated
sector
result
escalated
treatment
expenses
extended
hospitalization
periods.
In
industrial
context,
have
increasing
maintenance
product
contamination,
emphasizing
need
for
efficient
management
solutions.
This
review
presents
most
recent
progress
utilization
sophisticated
imaging
tools
molecular
methodologies.
addition
conventional
techniques,
explores
tools,
DNA
RNA
sequencing,
conjunction
proteomics.
These
approaches
essential
assessing
genetic
metabolic
mechanisms
that
regulate
development
resistance.
underscores
significance
employing
interdisciplinary
methodology
study
By
incorporating
range
approaches,
analysis,
comprehensive
understanding
may
be
achieved.
approach
opens
up
possibilities
developing
novel
solutions
address
negative
impacts
health,
environment.
Apmis,
Год журнала:
2024,
Номер
132(5), С. 291 - 316
Опубликована: Март 11, 2024
Invasive
fungal
infections
in
humans
caused
by
several
Candida
species,
increased
considerably
immunocompromised
or
critically
ill
patients,
resulting
substantial
morbidity
and
mortality.
albicans
is
the
most
prevalent
although
frequency
of
these
organisms
varies
greatly
according
to
geographic
region.
Infections
with
C.
non‐albicans
species
have
become
more
common,
especially
past
20
years,
as
a
result
aging,
immunosuppressive
medication
use,
endocrine
disorders,
malnourishment,
extended
use
medical
equipment,
an
increase
immunogenic
diseases.
Despite
being
frequently
associated
human
infections,
glabrata
,
parapsilosis
tropicalis
krusei
also
been
identified.
Several
antifungal
drugs
different
modes
action
are
approved
for
clinical
settings
treat
infections.
However,
due
common
eukaryotic
structure
fungi,
only
limited
number
available
therapeutic
use.
Furthermore,
drug
resistance
has
emerged
growing
currently
against
Amphotericin
B
(AmB),
polyene
class
drugs,
mainly
used
treatment
serious
systemic
AmB
interacts
plasma
membrane
ergosterol,
triggering
cellular
ion
leakage
via
pore
formation,
extracting
ergosterol
from
inducing
death.
primarily
changes
content
ergosterol.
This
review
summarizes
exhibited
special
focus
on
AmB.
