Nanomaterials for liver cancer targeting: research progress and future prospects DOI Creative Commons
Jiahong Xu,

Yefu Liu

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

The incidence and mortality rates of liver cancer in China remain elevated. Although early-stage is amenable to surgical resection, a significant proportion patients are diagnosed at advanced stages. Currently, addition resection for hepatocellular carcinoma, the primary treatment modalities predominantly include chemotherapy. widespread use chemotherapy, which non-selectively targets both malignant healthy cells, often results substantial immunosuppression. Simultaneously, accumulation chemotherapeutic agents can readily induce drug resistance upon reaching physiological threshold, thereby diminishing efficacy these treatments. Besides there exist targeted therapy, immunotherapy other therapeutic approaches. Nevertheless, development remains an inevitable challenge. To address challenges, we turn nanomedicine, emerging widely utilized discipline that significantly influences medical imaging, antimicrobial strategies, delivery systems, related areas. Stable safe nanomaterials serve as effective carriers delivering anticancer drugs. They enhance precision targeting, improve bioavailability, minimize damage cells. This review focuses on common nanomaterial used carcinoma (HCC) over past five years. following summary three drugs: Sorafenib, Gefitinib, lenvatinib. Each employs distinct result varying levels release rates, efficacy.

Language: Английский

Emerging Applications of Nanotechnology in Healthcare and Medicine DOI Creative Commons
Shiza Malik, Khalid Muhammad, Yasir Waheed

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6624 - 6624

Published: Sept. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Language: Английский

Citations

213
Zinc–Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy Therapy DOI
Yujie Lu, Youdong Chen,

Guanghui Hou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10542 - 10556

Published: April 1, 2024

Immunotherapy has emerged as a potential approach for breast cancer treatment. However, the rigid stromal microenvironment and low immunogenicity of tumors strongly reduce sensitivity to immunotherapy. To sensitize patients immunotherapy, hyaluronic acid-modified zinc peroxide–iron nanocomposites (Fe-ZnO2@HA, abbreviated FZOH) were synthesized remodel increase tumor immunogenicity. The constructed FZOH spontaneously generated highly oxidative hydroxyl radicals (·OH) that degrade acid (HA) in extracellular matrix (ECM), thereby reshaping enhancing blood perfusion, drug penetration, immune cell infiltration. Furthermore, not only triggers pyroptosis through activation caspase-1/GSDMD-dependent pathway but also induces ferroptosis various mechanisms, including increasing levels Fe2+ intracellular iron pool, downregulating expression FPN1 inhibit efflux, activating p53 signaling cause failure SLC7A11-GSH-GPX4 axis. Upon treatment with FZOH, 4T1 cells undergo both pyroptosis, exhibiting strong immunogenic response. remodeling response induced by collectively compensate limitations immunotherapy significantly enhance antitumor checkpoint inhibitor αPD-1. This study proposes perspective therapy cancer.

Language: Английский

Citations

26
A Single‐Atom Manganese Nanozyme Mn‐N/C Promotes Anti‐Tumor Immune Response via Eliciting Type I Interferon Signaling DOI Creative Commons
Wen Qiao, Jingqi Chen,

Huayuan Zhou

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Tumor microenvironment (TME)-induced nanocatalytic therapy is a promising strategy for cancer treatment, but the low catalytic efficiency limits its therapeutic efficacy. Single-atom catalysts (SACs) are new type of nanozyme with incredible efficiency. Here, single-atom manganese (Mn)-N/C constructed. Mn-N/C catalyzes conversion cellular H

Language: Английский

Citations

22
Research progress of organic photothermal agents delivery and synergistic therapy systems DOI
Yuan Li,

Haolong Qi,

Yingjie Geng

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113743 - 113743

Published: Jan. 5, 2024

Language: Английский

Citations

21
Enhanced Photodynamic Therapy Synergizing with Inhibition of Tumor Neutrophil Ferroptosis Boosts Anti‐PD‐1 Therapy of Gastric Cancer DOI Creative Commons
Xudong Zhu,

Wenxuan Zheng,

Xingzhou Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 17, 2024

Abstract For tumor treatment, the ultimate goal in therapy is to eliminate primary tumor, manage potential metastases, and trigger an antitumor immune response, resulting complete clearance of all malignant cells. Tumor microenvironment (TME) refers local biological environment solid tumors has increasingly become attractive target for cancer therapy. Neutrophils within TME gastric (GC) spontaneously undergo ferroptosis, this process releases oxidized lipids that limit T cell activity. Enhanced photodynamic (PDT) mediated by di‐iodinated IR780 (Icy7) significantly increases production reactive oxygen species (ROS). Meanwhile, neutrophil ferroptosis can be triggered increased ROS generation TME. In study, a liposome encapsulating both inhibitor Liproxstatin‐1 modified photosensitizer Icy7, denoted LLI, inhibits growth GC. LLI internalizes into MFC cells generate causing immunogenic death (ICD). Simultaneously, liposome‐deliver effectively neutrophils. LLI‐based PDT neutrophil‐targeting immunotherapy synergistically boost anti‐PD‐1 treatment elicit potent systemic response with abscopal effects. conclusion, holds great GC immunotherapy.

Language: Английский

Citations

20
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4
Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment DOI Creative Commons
Qiuyan Guo,

Yingnan Tang,

Shengmei Wang

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

Citations

2
Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform DOI Creative Commons

Qiuyan Guo,

Shengmei Wang,

Rubing Xu

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10608 - 10637

Published: Jan. 1, 2024

This review summarized the function of cancer cell membranes and comprehensively discussed preparation membrane-coated nanoparticles (CCM-NPs) their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Language: Английский

Citations

15
Nanomedicine as a multimodal therapeutic paradigm against cancer: on the way forward in advancing precision therapy DOI
Puja Sandbhor, Pranoti Palkar, Sakshi Bhat

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(13), P. 6330 - 6364

Published: Jan. 1, 2024

Graphical representation of recent advancements in combinatorial anticancer treatment modalities.

Language: Английский

Citations

14
Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy DOI
Jiajun Chen, Qi Zhou, Wenwu Cao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

Citations

14