Sexual arousal gates visual processing during Drosophila courtship

Nature, Год журнала: 2021, Номер 595(7868), С. 549 - 553

Опубликована: Июль 7, 2021

Язык: Английский

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Generating parallel representations of position and identity in the olfactory system

Cell, Год журнала: 2023, Номер 186(12), С. 2556 - 2573.e22

Опубликована: Май 25, 2023

In Drosophila, a dedicated olfactory channel senses male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in 5-mm range around male. Second-order projection encode the angular position of by detecting inter-antennal concentration, which are amplified through contralateral inhibition. At third circuit layer, identify 47 cell types with diverse input-output connectivity. One population responds tonically flies, second is tuned looming, integrates taste coincidentally promote mating. The separation features resembles mammalian what where visual streams; together multisensory integration, this enables behavioral responses appropriate specific ethological contexts.

Язык: Английский

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Re-evaluation of learned information in Drosophila

Nature, Год журнала: 2017, Номер 544(7649), С. 240 - 244

Опубликована: Апрель 1, 2017

Язык: Английский

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Dopaminergic Circuitry Underlying Mating Drive

Neuron, Год журнала: 2016, Номер 91(1), С. 168 - 181

Опубликована: Июнь 12, 2016

Язык: Английский

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Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace

Cell Reports, Год журнала: 2018, Номер 25(3), С. 651 - 662.e5

Опубликована: Окт. 1, 2018

It remains unclear how memory engrams are altered by experience, such as new learning, to cause forgetting. Here, we report that short-term aversive in Drosophila is encoded and retrieved from the mushroom body output neuron MBOn-γ2α′1. Pairing an odor with electric shock creates a robust depression calcium response of MBOn-γ2α′1 increases avoidance paired odor. Electric after which activates cognate dopamine DAn-γ2α′1, restores properties causes behavioral Conditioning second responses previously learned while depressing newly odor, showing learning forgetting can occur simultaneously. Moreover, optogenetic activation DAn-γ2α′1 sufficient for bidirectional modulation properties. Thus, single DAn drive both bidirectionally modulating cellular trace.

Язык: Английский

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Representations of Novelty and Familiarity in a Mushroom Body Compartment

Cell, Год журнала: 2017, Номер 169(5), С. 956 - 969.e17

Опубликована: Май 1, 2017

Язык: Английский

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Machine vision methods for analyzing social interactions

Journal of Experimental Biology, Год журнала: 2017, Номер 220(1), С. 25 - 34

Опубликована: Янв. 1, 2017

ABSTRACT Recent developments in machine vision methods for automatic, quantitative analysis of social behavior have immensely improved both the scale and level resolution with which we can dissect interactions between members same species. In this paper, review these methods, a particular focus on how biologists apply them to their own work. We discuss several components vision-based analyses: record high-quality video automated analyses, video-based tracking algorithms estimating positions interacting animals, learning recognizing patterns interactions. These are extremely general applicability, subset successful applications biological questions model systems very different types behaviors.

Язык: Английский

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The Neural Circuitry that Functions as a Switch for Courtship versus Aggression in Drosophila Males

Current Biology, Год журнала: 2016, Номер 26(11), С. 1395 - 1403

Опубликована: Май 12, 2016

Язык: Английский

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Functional Imaging and Optogenetics in Drosophila

Genetics, Год журнала: 2018, Номер 208(4), С. 1291 - 1309

Опубликована: Апрель 1, 2018

Abstract Understanding how activity patterns in specific neural circuits coordinate an animal’s behavior remains a key area of neuroscience research. Genetic tools and brain tractable complexity make Drosophila premier model organism for these studies. Here, we review the wealth reagents available to map manipulate neuronal with light.

Язык: Английский

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Cell types and neuronal circuitry underlying female aggression in Drosophila

eLife, Год журнала: 2020, Номер 9

Опубликована: Ноя. 3, 2020

Aggressive social interactions are used to compete for limited resources and regulated by complex sensory cues the organism's internal state. While both sexes exhibit aggression, its neuronal underpinnings understudied in females. Here, we identify a population of sexually dimorphic aIPg neurons adult Drosophila melanogaster central brain whose optogenetic activation increased, genetic inactivation reduced, female aggression. Analysis GAL4 lines identified an unbiased screen increased chasing behavior revealed involvement another neuron, pC1d, implicated pC1d as core nodes regulating Connectomic analysis demonstrated that interconnected suggest may exert part their effect gating flow visual information descending neurons. Our work reveals important regulatory components circuitry underlies aggressive provides tools manipulation.

Язык: Английский

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