Spontaneous behaviors drive multidimensional, brainwide activity

Science, Год журнала: 2019, Номер 364(6437)

Опубликована: Апрель 19, 2019

Neuron activity across the brain How is it that groups of neurons dispersed through interact to generate complex behaviors? Three papers in this issue present brain-scale studies neuronal and dynamics (see Perspective by Huk Hart). Allen et al. found thirsty mice, there widespread neural related stimuli elicit licking drinking. Individual encoded task-specific responses, but every area contained with different types response. Optogenetic stimulation thirst-sensing one reinstated drinking previously signaled thirst. Gründemann investigated mouse basal amygdala relation behavior during tasks. Two ensembles showed orthogonal exploratory nonexploratory behaviors, possibly reflecting levels anxiety experienced these areas. Stringer analyzed spontaneous firing, finding primary visual cortex both information motor facial movements. The variability responses mainly arousal reflects encoding latent behavioral states. Science , p. eaav3932 eaav8736 eaav7893 ; see also 236

Язык: Английский

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Predictive Processing: A Canonical Cortical Computation

Neuron, Год журнала: 2018, Номер 100(2), С. 424 - 435

Опубликована: Окт. 1, 2018

Язык: Английский

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A Sensorimotor Circuit in Mouse Cortex for Visual Flow Predictions

Neuron, Год журнала: 2017, Номер 95(6), С. 1420 - 1432.e5

Опубликована: Сен. 1, 2017

Язык: Английский

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Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex

Neuron, Год журнала: 2018, Номер 98(3), С. 602 - 615.e8

Опубликована: Апрель 12, 2018

Язык: Английский

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Mechanisms underlying gain modulation in the cortex

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(2), С. 80 - 92

Опубликована: Янв. 7, 2020

Язык: Английский

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Video-rate volumetric functional imaging of the brain at synaptic resolution

Nature Neuroscience, Год журнала: 2017, Номер 20(4), С. 620 - 628

Опубликована: Фев. 27, 2017

Язык: Английский

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Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning

Biological Psychiatry, Год журнала: 2017, Номер 83(10), С. 800 - 809

Опубликована: Окт. 14, 2017

Associative memory formation is essential for an animal's survival by ensuring adaptive behavioral responses in ever-changing environment. This particularly important under conditions of immediate threats such as fear learning. One the key brain regions involved associative learning amygdala. The basolateral amygdala main entry site sensory information to complex, and local plasticity excitatory principal neurons considered be crucial conditioned responses. However, activity circuits are tightly controlled inhibitory interneurons a spatially temporally defined manner. In this review, we provide updated view on how distinct interneuron subtypes contribute acquisition extinction memories.

Язык: Английский

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Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits

Trends in Neurosciences, Год журнала: 2018, Номер 41(10), С. 689 - 700

Опубликована: Сен. 25, 2018

Язык: Английский

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Locomotion Enhances Neural Encoding of Visual Stimuli in Mouse V1

Journal of Neuroscience, Год журнала: 2017, Номер 37(14), С. 3764 - 3775

Опубликована: Март 6, 2017

Neurons in mouse primary visual cortex (V1) are selective for particular properties of stimuli. Locomotion causes a change cortical state that leaves their selectivity unchanged but strengthens responses. Both locomotion and the thought to be initiated by projections from mesencephalic locomotor region, latter through disinhibitory circuit V1. By recording simultaneously large number single neurons alert mice viewing moving gratings, we investigated relationship between information contained within neural population. We found improved encoding stimuli V1 two mechanisms. First, locomotion-induced increases firing rates enhanced mutual neuron responses over fixed window time. Second, stimulus discriminability was improved, even population rates, because decrease noise correlations across These mechanisms contributed differently improvements layers, with changes most important upper layers layer V. Together, these resulted threefold fivefold reduction time needed precisely encode grating direction orientation. results support hypothesis shifts during accommodate an increased load on system when moving. SIGNIFICANCE STATEMENT This paper contains three novel findings about representation mouse. show reduces at least factor 3 accumulate allows distinction different effect is increase cells all cortex. Third, means which differs where major increasing V, correlations.

Язык: Английский

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A New Perspective on Predictive Motor Signaling

Current Biology, Год журнала: 2018, Номер 28(5), С. R232 - R243

Опубликована: Март 1, 2018

Язык: Английский

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