Current Biology,
Год журнала:
2018,
Номер
28(22), С. 3610 - 3624.e8
Опубликована: Ноя. 1, 2018
Sleep
is
ancient
and
fulfills
higher
brain
functions
as
well
basic
vital
processes.
Little
known
about
how
sleep
emerged
in
evolution
what
essential
it
was
selected
for.
Here,
we
investigated
Caenorhabditis
elegans
across
developmental
stages
physiological
conditions
to
find
out
when
a
simple
animal
becomes
for
survival.
We
found
that
worms
occurs
during
most
typically
induced
by
the
sleep-active
RIS
neuron.
Food
quality
availability
determine
amount.
Extended
starvation,
which
induces
arrest
larvae,
presents
major
trigger.
Conserved
nutrient-sensing
regulators
of
longevity
arrest,
AMP-activated
kinase
FoxO,
act
parallel
induce
extended
food
deprivation.
These
metabolic
factors
can
multiple
tissues
signal
starvation
RIS.
Although
does
not
appear
be
normal
adult
lifespan,
crucial
survival
starvation-induced
larvae.
Rather
than
merely
saving
energy
later
use,
counteracts
progression
aging
phenotypes,
perhaps
allocating
resources.
Thus,
protective
anti-aging
program
pathways
survive
arrest.
All
organisms
are
threatened
with
possibility
experienced
famine
their
life,
suggests
molecular
coupling
development,
aging,
early
nervous
systems
may
conserved
other
species,
including
humans.
Frontiers in Neurology,
Год журнала:
2018,
Номер
9
Опубликована: Авг. 24, 2018
Skeletal
muscle
is
an
essential
regulator
of
energy
homeostasis
and
a
potent
coordinator
exercise-induced
adaptations
in
other
organs
including
the
liver,
fat
or
brain.
muscle-initiated
crosstalk
with
tissues
accomplished
though
secretion
myokines,
protein
hormones
which
can
exert
autocrine,
paracrine
long-distance
endocrine
effects.
In
addition,
enhanced
release
uptake
metabolites
from
into
contracting
cells,
respectively,
likewise
act
as
powerful
mediator
tissue
interactions,
particular
regard
to
central
nervous
system.
The
present
review
will
discuss
current
stage
knowledge
regarding
how
exercise
secretome
improve
broad
range
brain
functions
related
vascularization,
neuroplasticity,
memory,
sleep
mood.
Even
molecular
cellular
mechanisms
underlying
communication
between
still
poorly
understood,
physical
activity
represents
one
most
effective
strategies
reduce
prevalence
incidence
depression,
cognitive,
metabolic
degenerative
neuronal
disorders,
thus
warrants
further
study.
Science,
Год журнала:
2020,
Номер
367(6479), С. 800 - 806
Опубликована: Фев. 14, 2020
Circadian
(~24
hour)
clocks
have
a
fundamental
role
in
regulating
daily
physiology.
The
transcription
factor
BMAL1
is
principal
driver
of
molecular
clock
mammals.
Bmal1
deletion
abolishes
24-hour
activity
patterning,
one
measure
output.
We
determined
whether
function
necessary
for
oscillations
skin
fibroblasts
and
liver
slices.
Unexpectedly,
knockout
mice,
both
tissues
exhibited
the
transcriptome,
proteome,
phosphoproteome
over
2
to
3
days
absence
any
exogenous
drivers
such
as
light
or
temperature
cycles.
This
demonstrates
competent
pacemaker
knockouts.
suggest
that
might
be
underpinned
by
transcriptional
regulation
recruitment
ETS
family
factors,
nontranscriptionally
co-opting
redox
oscillations.
Trouble
sleeping
is
one
of
the
major
health
issues
nowadays.
Current
evidence
on
correlation
between
muscle
quality
and
trouble
limited.A
cross-sectional
study
design
was
applied
participants
aged
from
18
to
60
years
in
National
Health
Nutrition
Examination
Survey
(NHANES)
2011-2014
used
for
analysis.
Muscle
index
(MQI)
quantitatively
calculated
as
handgrip
strength
(HGS,
kg)
sum/
arm
appendicular
skeletal
mass
(ASM,
by
using
sum
non-dominant
hand
dominant
hand.
Sleeping
data
obtained
interviews
self-reported
individuals.
The
main
analyses
utilized
weighted
multivariable
logistic
regression
models
according
complex
multi-stage
sampling
NHANES.
Restricted
cubic
spline
model
explore
non-linear
relationship
MQI
sleeping.
Moreover,
subgroup
concerning
sociodemographic
lifestyle
factors
were
conducted
this
study.5143
finally
included
in.
In
fully
adjusted
model,
an
increased
level
significantly
associated
with
a
lower
odds
ratio
sleeping,
OR
=
0.765,
95%
CI:
(0.652,0.896),
p
0.011.
showed
association
However,
it
seemed
that
prevalence
decreased
increasing
until
reached
2.362,
after
which
plateau.
Subgroup
further
confirmed
negative
consistent
robust
across
groups.Overall,
revealed
can
be
reliable
predictor
Maintaining
certain
would
beneficial
sleep
health.
study,
causal
inference
worthy
exploration.
Neuropsychopharmacology,
Год журнала:
2019,
Номер
45(1), С. 176 - 191
Опубликована: Июнь 11, 2019
The
military
lifestyle
often
includes
continuous
operations
whether
in
training
or
deployed
environments.
These
stressful
environments
present
unique
challenges
for
service
members
attempting
to
achieve
consolidated,
restorative
sleep.
significant
mental
and
physical
derangements
caused
by
degraded
metabolic,
cardiovascular,
skeletomuscular,
cognitive
health
result
from
insufficient
sleep
and/or
circadian
misalignment.
Insufficient
resulting
fatigue
compromises
personal
safety,
mission
success,
even
national
security.
In
the
long-term,
chronic
rhythm
disorders
have
been
associated
with
other
(e.g.,
insomnia,
obstructive
apnea,
parasomnias).
Other
physiologic
psychologic
diagnoses
such
as
post-traumatic
stress
disorder,
cardiovascular
disease,
dementia
also
chronic,
Increased
co-morbidity
mortality
are
compounded
traumatic
brain
injury
blunt
trauma,
blast
exposure,
highly
physically
demanding
tasks
under
load.
We
current
state
of
science
human
animal
models
specific
during-
post-military
career.
focus
on
requirements
night
shift
work,
sustained
operations,
rapid
re-entrainment
time
zones.
then
propose
targeted
pharmacological
non-pharmacological
countermeasures
optimize
performance
that
mission-
symptom-specific.
recognize
a
critical
gap
research
involving
members,
but
provide
tailored
interventions
care
providers
based
large
body
public
workers.
