Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Сен. 26, 2023
Abstract
Social
recognition
memory
(SRM)
is
a
key
determinant
of
social
interactions.
While
the
cerebellum
emerges
as
an
important
region
for
behavior,
how
cerebellar
activity
affects
functions
remains
unclear.
We
selectively
increased
excitability
molecular
layer
interneurons
(MLIs)
to
suppress
Purkinje
cell
firing
in
mouse
vermis.
Chemogenetic
perturbation
MLIs
impaired
SRM
without
affecting
sociability,
anxiety
levels,
motor
coordination
or
object
recognition.
Optogenetic
interference
during
distinct
phases
test
revealed
engagement
retrieval,
but
not
encoding,
information.
c-Fos
mapping
after
showed
that
manipulation
decreased
brain-wide
interregional
correlations
and
altered
network
structure
from
medial
prefrontal
cortex
hippocampus-centered
amygdala-centered
modules.
Anatomical
tracing
demonstrated
hierarchical
projections
central
brain
integrating
amygdalar
connections.
Our
findings
suggest
organizes
neural
matrix
necessary
SRM.
Journal of Neuroscience,
Год журнала:
2023,
Номер
43(45), С. 7554 - 7564
Опубликована: Ноя. 8, 2023
The
cerebellum,
traditionally
associated
with
motor
coordination
and
balance,
also
plays
a
crucial
role
in
various
aspects
of
higher-order
function
dysfunction.
Emerging
research
has
shed
light
on
the
cerebellum's
broader
contributions
to
cognitive,
emotional,
reward
processes.
influence
autonomic
further
highlights
its
significance
regulating
motivational
emotional
states.
Perturbations
cerebellar
development
have
been
implicated
neurodevelopmental
disorders,
including
autism
spectrum
disorder
attention
deficit
hyperactivity
disorder.
An
increasing
appreciation
for
neuropsychiatric
symptoms
that
arise
from
dysfunction
underscores
importance
elucidating
circuit
mechanisms
underlie
complex
interactions
between
cerebellum
other
brain
regions
comprehensive
understanding
behavior.
By
briefly
discussing
new
advances
mapping
affective,
autonomic,
social
processing
reviewing
neuropathology
beyond
domain,
this
Mini-Symposium
review
aims
provide
broad
perspective
intersections
limbic
health
disease.
iScience,
Год журнала:
2020,
Номер
23(3), С. 100894 - 100894
Опубликована: Фев. 11, 2020
Ventral
hippocampus
(vHIP)
and
medial
prefrontal
cortex
(mPFC)
are
both
critical
regions
for
social
behaviors.
However,
how
their
interactions
affect
behavior
is
not
well
understood.
By
viral
tracing,
optogenetics,
chemogenetics,
fiber
photometry,
we
demonstrated
that
inhibition
of
vHIP
or
direct
projections
from
to
mPFC
impaired
memory
expression.
Via
rabies
retrograde
found
all
three
major
GABAergic
neurons
in
received
inputs
vHIP.
Activation
parvalbumin
positive
(PV+)
but
somatostatin
(SST+)
can
rescue
the
impairment
caused
by
inhibition.
Furthermore,
photometry
results
behaviors
preferentially
recruited
PV+
hippocampal
disrupted
activity
during
interactions.
These
revealed
a
new
mechanism
regulate
complementarity
with
existing
neural
circuitry
mechanism.
Current Biology,
Год журнала:
2020,
Номер
30(19), С. 3761 - 3774.e6
Опубликована: Авг. 20, 2020
Birth
by
Caesarean
(C)-section
impacts
early
gut
microbiota
colonization
and
is
associated
with
an
increased
risk
of
developing
immune
metabolic
disorders.
Moreover,
alterations
the
microbiome
have
been
shown
to
affect
neurodevelopmental
trajectories.
However,
long-term
effects
C-section
on
neurobehavioral
processes
remain
unknown.
Here,
we
demonstrated
that
birth
results
in
marked
but
transient
changes
composition
mouse,
particular,
abundance
Bifidobacterium
spp.
was
depleted
life.
Mice
born
had
enduring
social,
cognitive,
anxiety
deficits
life
adulthood.
Interestingly,
found
these
specific
behavioral
induced
mode
were
also
partially
corrected
co-housing
vaginally
mice.
Finally,
showed
supplementation
from
a
breve
strain,
or
dietary
prebiotic
mixture
stimulates
growth
bifidobacteria,
reverses
selective
Taken
together,
our
data
link
C-section-born
mice
suggest
possibility
adjunctive
microbiota-targeted
therapies
may
help
avert
negative
consequences
behavior
mode.
Frontiers in Behavioral Neuroscience,
Год журнала:
2021,
Номер
15
Опубликована: Июнь 21, 2021
Despite
decades
of
research
on
the
neurobiology
major
depressive
disorder
(MDD),
mechanisms
underlying
its
expression
remain
unknown.
The
medial
prefrontal
cortex
(mPFC),
a
hub
region
involved
in
emotional
processing
and
stress
response
elaboration,
is
highly
impacted
MDD
patients
animal
models
chronic
stress.
Recent
advances
showed
alterations
morphology
activity
mPFC
neurons
along
with
profound
changes
their
transcriptional
programs.
Studies
at
circuitry
level
highlighted
relevance
deciphering
contributions
distinct
circuits
elaboration
adapted
maladapted
behavioral
responses
context
Interestingly,
presents
sexual
dimorphism,
feature
recognized
molecular
field
but
understudied
circuit
level.
This
review
examines
recent
literature
summarizes
contribution
males
females
morphological
functional
that
change
these
neuronal
human
depressive-like
behaviors.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2022,
Номер
377(1845)
Опубликована: Янв. 10, 2022
Across
species,
animals
organize
into
social
dominance
hierarchies
that
serve
to
decrease
aggression
and
facilitate
survival
of
the
group.
Neuroscientists
have
adopted
several
model
organisms
study
in
laboratory
setting,
including
fish,
reptiles,
rodents
primates.
We
review
recent
literature
across
species
sheds
light
onto
how
brain
represents
rank
guide
socially
appropriate
behaviour
within
a
hierarchy.
First,
we
discuss
responds
status
signals.
Then,
approach
avoidance
learning
mechanisms
propose
could
drive
rank-appropriate
behaviour.
Lastly,
memories
individuals
(social
memory)
this
may
support
maintenance
unique
individual
relationships
This
article
is
part
theme
issue
‘The
centennial
pecking
order:
current
state
future
prospects
for
hierarchies’.
