Optogenetic activation of mesencephalic projections to the nucleus accumbens shell impairs probabilistic reversal learning by disrupting learning from negative reinforcement DOI Creative Commons
Katharina Zühlsdorff, Júlia Sala‐Bayo,

Sammy Piller

и другие.

European Journal of Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Abstract Cognitive flexibility, the capacity to adapt behaviour changes in environment, is impaired a range of brain disorders, including schizophrenia and Parkinson's disease. Putative neural substrates cognitive flexibility include mesencephalic pathways ventral striatum (VS) dorsomedial (DMS), hypothesized encode learning signals needed maximize rewarded outcomes during decision‐making. However, it unclear whether projections dorsal are distinct their contribution flexible reward‐related learning. Here, rats acquired two‐choice spatial probabilistic reversal (PRL) task, reinforced on an 80%|20% basis (correct|incorrect responses) that assessed repeated reversals response‐outcome contingencies. We report optogenetic stimulation from tegmental area (VTA) nucleus accumbens shell (NAcS) VS significantly when optical was temporally aligned with negative feedback (i.e., reward omission). VTA → NAcS other phases behavioural task without significant effect. Optogenetic projection neurons substantia nigra (SN) DMS, either receipt or omission prior making choice, had no effect These findings consistent notion increased activity pathway disrupts by impairing reinforcement.

Язык: Английский

Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state DOI

Scott S. Bolkan,

Iris R. Stone, Lucas Pinto

и другие.

Nature Neuroscience, Год журнала: 2022, Номер 25(3), С. 345 - 357

Опубликована: Март 1, 2022

Язык: Английский

Процитировано

84
The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands DOI
John G. Howland, Rutsuko Ito, Christopher C. Lapish

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 135, С. 104569 - 104569

Опубликована: Фев. 4, 2022

Язык: Английский

Процитировано

38
Nigrostriatal dopamine pathway regulates auditory discrimination behavior DOI Creative Commons
Allen P. F. Chen, Jeffrey M. Malgady, Chen Lu

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Окт. 8, 2022

Abstract The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated perceptual decision-making, transforming stimuli to action outcomes. Despite its known connections diverse neurological conditions, dopaminergic modulation sensory striatal neuronal activity and behavioral influences remain unknown. We demonstrated that optogenetic inhibition projections from substantia nigra pars compacta specifically impairs mouse choice performance but not movement an frequency discrimination task. In vivo dopamine calcium imaging freely behaving mice revealed this projection modulates tone representations, tone-evoked release inversely correlated with evidence strength tones. Optogenetic D1-receptor expressing neurons pharmacological D1 receptors dampened accuracy. Our study uncovers a phasic mechanism within nigrostriatal system regulates decisions by modulating ongoing perception.

Язык: Английский

Процитировано

36
The cortico-striatal circuitry in autism-spectrum disorders: a balancing act DOI Creative Commons
Jean‐Jacques Soghomonian

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Янв. 11, 2024

The basal ganglia are major targets of cortical inputs and, in turn, modulate function via their projections to the motor and prefrontal cortices. role control reward is well documented there also extensive evidence that they play a key social repetitive behaviors. influence activity cerebral cortex two from striatum output nuclei, globus pallidus internus substantia nigra, pars reticulata. This modulation involves direct projection known as pathway an indirect externus subthalamic nucleus, pathway. review discusses respective contribution pathways behaviors neurotypical conditions autism spectrum disorders.

Язык: Английский

Процитировано

8
Mystery of the memory engram: History, current knowledge, and unanswered questions DOI Creative Commons
Matthew R. Lopez,

S.M.H. Wasberg,

Celia Gagliardi

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 159, С. 105574 - 105574

Опубликована: Фев. 6, 2024

The quest to understand the memory engram has intrigued humans for centuries. Recent technological advances, including genetic labelling, imaging, optogenetic and chemogenetic techniques, have propelled field of research forward. These tools enabled researchers create erase components. While these innovative techniques yielded invaluable insights, they often focus on specific elements trace. Genetic labelling may rely a particular immediate early gene as marker activity, optogenetics activate or inhibit one type neuron, imaging capture activity snapshots in given brain region at times. Yet, memories are multifaceted, involving diverse arrays neuronal subpopulations, circuits, regions that work concert create, store, retrieve information. Consideration contributions both excitatory inhibitory neurons, micro macro circuits across regions, dynamic nature active ensembles, representational drift is crucial comprehensive understanding complex memory.

Язык: Английский

Процитировано

7
Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning DOI Creative Commons
James Peak, Billy Chieng, Genevra Hart

и другие.

eLife, Год журнала: 2020, Номер 9

Опубликована: Ноя. 20, 2020

The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action; however, the role of direct (dSPN) and indirect (iSPN) spiny projection neurons in pDMS such actions remains unclear. In this series experiments, we examined SPNs action rats found that whereas dSPNs were critical learning energizing learned response, iSPNs involved updating to support response flexibility. Instrumental training elevated expression plasticity marker Zif268 only, chemogenetic suppression dSPN activity during prevented learning. Unilateral optogenetic inhibition induced an ipsilateral bias performance. contrast, although initial was unaffected by iSPN manipulations, iSPNs, but not dSPNs, impaired attenuated flexibility after changes action-outcome contingency.

Язык: Английский

Процитировано

48
Striatal dopamine release tracks the relationship between actions and their consequences DOI Creative Commons
Genevra Hart, Thomas J. Burton, Christopher Nolan

и другие.

Cell Reports, Год журнала: 2024, Номер 43(3), С. 113828 - 113828

Опубликована: Фев. 21, 2024

The acquisition and performance of goal-directed actions has long been argued to depend on the integration glutamatergic inputs posterior dorsomedial striatum (pDMS) under modulatory influence dopamine. Nevertheless, relatively little is known about dynamics striatal dopamine during actions. To investigate this, we chronically recorded release in pDMS as rats acquired two for distinct outcomes these action-outcome associations were incremented then subsequently degraded or reversed. We found that bilateral scaled with action value, whereas lateralized signal, i.e., difference ipsilaterally contralaterally direction action, reflected strength association independently changes movement. Our results establish, therefore, activity reflects both moment-to-moment value long-term association.

Язык: Английский

Процитировано

5
What Role Does Striatal Dopamine Play in Goal-directed Action? DOI Creative Commons
Genevra Hart, Thomas J. Burton, Bernard W. Balleine

и другие.

Neuroscience, Год журнала: 2024, Номер 546, С. 20 - 32

Опубликована: Март 21, 2024

Evidence suggests that dopamine activity provides a US-related prediction error for Pavlovian conditioning and the reinforcement signal supporting acquisition of habits. However, its role in goal-directed action is less clear. There are currently few studies have assessed release as animals acquire perform self-paced instrumental actions. Here we briefly review literature documenting psychological, behavioral neural bases actions rats mice, before turning to describe recent investigating learning performance. Plasticity dorsomedial striatum, central node network action, clearly requires release, timing which, relative cortical thalamic inputs, determines degree form plasticity. Beyond this, bilateral appears reflect reward errors experience consequences an action. Such signals feedforward update value specific associated with outcome during subsequent performance, at time reflecting updated predicted value. More recently, evidence has also emerged hemispherically lateralised action; greater hemisphere contralateral spatial target This effect emerges over course strength action-outcome association. Thus, their association shape performance processes necessary support this control.

Язык: Английский

Процитировано

5
A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa DOI Creative Commons
Kyna‐Anne Conn, Kaixin Huang, Sasha Gorrell

и другие.

International Journal of Eating Disorders, Год журнала: 2024, Номер 57(7), С. 1406 - 1417

Опубликована: Янв. 4, 2024

Abstract Objective The development of novel treatments for anorexia nervosa (AN) requires a detailed understanding the biological underpinnings specific, commonly occurring symptoms, including compulsive exercise. There is considerable bio‐behavioral overlap between AN and obsessive‐compulsive disorder (OCD), therefore it plausible that similar mechanisms underlie behavior in both populations. While association these conditions widely acknowledged, defining shared OCD approach. Methods We present an argument better neurobiological underpin exercise can be achieved two critical ways. First, by applying framework neuronal control to AN, second, taking advantage activity‐based (ABA) rodent model directly test this context feeding pathology. Results A cross‐disciplinary approach spans preclinical, neuroimaging, clinical research as well neurocircuitry advance our when, why, how develops provide targets treatment strategies. Discussion In article, we (i) link expression via transition goal‐directed habitual behavior, (ii) disrupted cortico‐striatal circuitry key substrate conditions, (iii) highlight utility ABA understand relevant AN. Public Significance Individuals with who compulsively are at risk worse health outcomes have poorer responses standard treatments. However, remains inadequately understood. Identifying whether neural underlying also controls hyperactivity will aid eating strategies high‐risk population.

Язык: Английский

Процитировано

4
Dynamics of striatal action selection and reinforcement learning DOI Creative Commons
Jack Lindsey, Jeffrey E. Markowitz, Winthrop F. Gillis

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 19, 2024

Abstract Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning the basal ganglia. Here, we identify and resolve fundamental inconsistency between striatal models known SPN synaptic plasticity rules. Direct-pathway (dSPN) indirect-pathway (iSPN) neurons, which promote suppress actions, respectively, exhibit that reinforces activity associated with elevated or suppressed dopamine release. We show iSPN prevents successful learning, it patterns negative outcomes. However, this pathological behavior is reversed if functionally opponent dSPNs iSPNs, current behavior, simultaneously activated by efferent input following action selection. This prediction supported recordings contrasts prior representations. In our model, selection signals can be multiplexed without interference, enabling algorithms beyond those standard temporal difference models.

Язык: Английский

Процитировано

4