Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body DOI Creative Commons
Ishani Ganguly, Emily L. Heckman, Ashok Litwin-Kumar

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 7, 2024

Abstract The arthropod mushroom body is well-studied as an expansion layer representing olfactory stimuli and linking them to contingent events. However, 8% of Kenyon cells in Drosophila melanogaster receive predominantly visual input, their function remains unclear. Here, we identify inputs using the FlyWire adult whole-brain connectome. Input repertoires are similar across hemispheres connectomes with certain highly overrepresented. Many neurons presynaptic have large receptive fields, while interneuron spatially restricted signals that may be tuned specific features. Individual randomly sample sparse from combinations channels, including multiple optic lobe neuropils. These connectivity patterns suggest coding body, like coding, sparse, distributed, combinatorial. input repertoire smaller population suggests a constrained encoding stimuli.

Язык: Английский

Connectome of the lamina reveals the circuit for early color processing in the visual pathway of a butterfly DOI Creative Commons
Atsuko Matsushita, Finlay J. Stewart, Marko Ilić

и другие.

Current Biology, Год журнала: 2022, Номер 32(10), С. 2291 - 2299.e3

Опубликована: Апрель 18, 2022

Язык: Английский

Процитировано

23
A complete reconstruction of the early visual system of an adult insect DOI Creative Commons
Nicholas J Chua, Anastasia A. Makarova, Pat Gunn

и другие.

Current Biology, Год журнала: 2023, Номер 33(21), С. 4611 - 4623.e4

Опубликована: Сен. 28, 2023

For most model organisms in neuroscience, research into visual processing the brain is difficult because of a lack high-resolution maps that capture complex neuronal circuitry. The microinsect Megaphragma viggianii, its small size and non-trivial behavior, provides unique opportunity for tractable whole-organism connectomics. We image whole head using serial electron microscopy. reconstruct compound eye analyze optical properties ommatidia as well connectome first neuropil-the lamina. Compared with fruit fly honeybee, system highly simplified: it has 29 per 6 lamina neuron types. report features are both stereotypical among specialized to some. By identifying "barebones" circuits critical flying insects, our results will facilitate constructing computational models insects.

Язык: Английский

Процитировано

15
Connectomic reconstruction predicts the functional organization of visual inputs to the navigation center of theDrosophilabrain DOI Creative Commons
Dustin Garner, Emil Kind, Aljoscha Nern

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 30, 2023

Many animals, including humans, navigate their surroundings by visual input, yet we understand little about how information is transformed and integrated the navigation system. In

Язык: Английский

Процитировано

14
A comprehensive neuroanatomical survey of the Drosophila Lobula Plate Tangential Neurons with predictions for their optic flow sensitivity DOI Open Access
Arthur Zhao, Aljoscha Nern, Sanna Koskela

и другие.

Опубликована: Янв. 9, 2024

Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential cells dipteran lobula plate, whose visual-motion responses, lesser extent, morphology, explored using single-neuron neurophysiology. Most these studies focused on large, Horizontal Vertical System neurons, yet plate houses much larger set ‘optic-flow’ many which challenging unambiguously identify or reliably target functional studies. Here we report comprehensive reconstruction identification Lobula Plate Tangential an Electron Microscopy (EM) volume whole Drosophila brain. This catalog 58 LPT (per brain hemisphere) contains described here first time provides basis systematic investigation circuitry linking locomotion control. Leveraging computational anatomy methods, estimated motion receptive fields compared tuning consequence body rotations translational movements. We also matched most cases one-for-one basis, stochastically labeled genetic driver lines, mirror-symmetric same EM volume, additional data set. Using cell matches across sets, analyzed integration downstream LPTs find central establish sharper selectivity global than input neurons. Furthermore, found information extracted from processed distinct regions brain, pointing diverse foci generation behaviors.

Язык: Английский

Процитировано

6
Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body DOI Creative Commons
Ishani Ganguly, Emily L. Heckman, Ashok Litwin-Kumar

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 7, 2024

Abstract The arthropod mushroom body is well-studied as an expansion layer representing olfactory stimuli and linking them to contingent events. However, 8% of Kenyon cells in Drosophila melanogaster receive predominantly visual input, their function remains unclear. Here, we identify inputs using the FlyWire adult whole-brain connectome. Input repertoires are similar across hemispheres connectomes with certain highly overrepresented. Many neurons presynaptic have large receptive fields, while interneuron spatially restricted signals that may be tuned specific features. Individual randomly sample sparse from combinations channels, including multiple optic lobe neuropils. These connectivity patterns suggest coding body, like coding, sparse, distributed, combinatorial. input repertoire smaller population suggests a constrained encoding stimuli.

Язык: Английский

Процитировано

6