A natural compound hyperoside targetsSalmonellaTyphimurium T3SS needle protein InvG DOI
Yong Zhang, Yan Liu, Bo Zhang

и другие.

Food & Function, Год журнала: 2022, Номер 13(19), С. 9761 - 9771

Опубликована: Янв. 1, 2022

After entry into the host cells, Salmonella Typhimurium creates a replication niche using its Type III system (T3SS). Hyperoside targets InvG to inhibit T3SS translocation of S. Typhimurium, thus inhibiting in cells.

Язык: Английский

Evolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains DOI Creative Commons
A. Ariza, Qiang Liu, Nathan Cowieson

и другие.

Journal of Biological Chemistry, Год журнала: 2024, Номер unknown, С. 107770 - 107770

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1
Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors DOI Creative Commons
D. Patel, P.J. Stogios,

Lukasz Jaroszewski

и другие.

Molecular Systems Biology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Язык: Английский

Процитировано

1
Legionella pneumophila , a Rosetta stone to understanding bacterial pathogenesis DOI

Katerina A. Romanov,

Tamara J. O’Connor

Journal of Bacteriology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

ABSTRACT Legionella pneumophila is an environmentally acquired pathogen that causes respiratory disease in humans. While the discovery of L. relatively recent compared to other bacterial pathogens, over past 50 years, has emerged as a powerhouse for studying host-pathogen interactions. In its natural habitat fresh water, interacts with diverse array protozoan hosts and readily evolve expand their host range. This led accumulation most extensive arsenal secreted virulence factors described ability infect Within amoebae human alveolar macrophages, bacteria replicate within specialized membrane-bound compartments, establishing model intracellular vacuolar pathogens. contrast, required replication are specifically tailored individual cells types, allowing adapt variation between disparate niches. The broad range this pathogen, combined diversity genome plasticity across genus, thus established bacterium archetype interrogate evolution, functional genomics, ecology. review, we highlight features establish them versatile organism, new paradigms bacteriology pathogenesis resulting from study , well current future questions will undoubtedly our understanding complex intricate biology microbial world.

Язык: Английский

Процитировано

1
Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents DOI Creative Commons
Virginie Stévenin, Jacques Neefjes

Cell chemical biology, Год журнала: 2022, Номер 29(5), С. 741 - 756

Опубликована: Май 1, 2022

Язык: Английский

Процитировано

6
A natural compound hyperoside targetsSalmonellaTyphimurium T3SS needle protein InvG DOI
Yong Zhang, Yan Liu, Bo Zhang

и другие.

Food & Function, Год журнала: 2022, Номер 13(19), С. 9761 - 9771

Опубликована: Янв. 1, 2022

After entry into the host cells, Salmonella Typhimurium creates a replication niche using its Type III system (T3SS). Hyperoside targets InvG to inhibit T3SS translocation of S. Typhimurium, thus inhibiting in cells.

Язык: Английский

Процитировано

6