Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.
GC
pairs
are
generally
more
stable
than
AT
pairs;
GC-rich
genomes
were
proposed
to
be
adapted
high
temperatures
AT-rich
genomes.
Previous
studies
consistently
showed
positive
correlations
between
growth
temperature
and
the
contents
of
structural
RNA
genes.
However,
for
whole
genome
sequences
silent
sites
codons
in
protein-coding
genes,
relationship
content
is
a
long-lasting
debate.
Translational Neurodegeneration,
Год журнала:
2023,
Номер
12(1)
Опубликована: Апрель 14, 2023
Abstract
Redox
homeostasis
refers
to
the
balance
between
production
of
reactive
oxygen
species
(ROS)
as
well
nitrogen
(RNS),
and
their
elimination
by
antioxidants.
It
is
linked
all
important
cellular
activities
oxidative
stress
a
result
imbalance
pro-oxidants
antioxidant
species.
Oxidative
perturbs
many
activities,
including
processes
that
maintain
integrity
DNA.
Nucleic
acids
are
highly
therefore
particularly
susceptible
damage.
The
DNA
damage
response
detects
repairs
these
lesions.
Efficient
repair
essential
for
maintaining
viability,
but
they
decline
considerably
during
aging.
deficiencies
in
increasingly
described
age-related
neurodegenerative
diseases,
such
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis
Huntington’s
disease.
Furthermore,
has
long
been
associated
with
conditions.
Moreover,
both
redox
dysregulation
increase
significantly
aging,
which
biggest
risk
factor
diseases.
However,
links
dysfunction
damage,
joint
contributions
pathophysiology
conditions,
only
just
emerging.
This
review
will
discuss
associations
address
increasing
evidence
an
major
source
disorders.
Understanding
connections
may
facilitate
better
understanding
disease
mechanisms,
ultimately
lead
design
therapeutic
strategies
based
on
preventing
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(6), С. 5105 - 5105
Опубликована: Март 7, 2023
The
purpose
of
this
review
is
to
critically
evaluate
the
effects
different
stress
factors
on
higher
plants,
with
particular
attention
given
typical
and
unique
dose-dependent
responses
that
are
essential
for
plant
growth
development.
Specifically,
highlights
impact
genome
instability,
including
DNA
damage
molecular,
physiological,
biochemical
mechanisms
generate
these
effects.
We
provide
an
overview
current
understanding
predictable
trends
in
survival
when
exposed
low
or
high
doses
stress.
Understanding
both
negative
positive
impacts
responses,
can
insights
into
how
plants
react
levels
stress,
yielding
more
accurate
predictions
their
behavior
natural
environment.
Applying
acquired
knowledge
lead
improved
crop
productivity
potential
development
resilient
varieties,
ensuring
a
sustainable
food
source
rapidly
growing
global
population.
Molecular Biology of the Cell,
Год журнала:
2024,
Номер
35(3)
Опубликована: Янв. 3, 2024
Cell
Painting
assays
generate
morphological
profiles
that
are
versatile
descriptors
of
biological
systems
and
have
been
used
to
predict
in
vitro
vivo
drug
effects.
However,
features
extracted
from
classical
software
such
as
CellProfiler
based
on
statistical
calculations
often
not
readily
biologically
interpretable.
In
this
study,
we
propose
a
new
feature
space,
which
call
BioMorph,
maps
these
with
readouts
comprehensive
Health
assays.
We
validated
the
resulting
BioMorph
space
effectively
connected
compounds
only
associated
their
bioactivity
but
deeper
insights
into
phenotypic
characteristics
cellular
processes
given
bioactivity.
The
revealed
mechanism
action
for
individual
compounds,
including
dual-acting
emetine,
an
inhibitor
both
protein
synthesis
DNA
replication.
Overall,
offers
relevant
way
interpret
cell
derived
using
hypotheses
experimental
validation.
Heliyon,
Год журнала:
2024,
Номер
10(2), С. e24751 - e24751
Опубликована: Янв. 1, 2024
Aging
is
a
complex
and
inevitable
biological
process
affected
by
combination
of
external
environmental
genetic
factors.
Humans
are
currently
living
longer
than
ever
before,
accompanied
with
aging-related
alterations
such
as
diminished
autophagy,
decreased
immunological
function,
mitochondrial
malfunction,
stem
cell
failure,
accumulation
somatic
DNA
mutations,
loss
telomere,
altered
nutrient
metabolism.
leads
to
decline
in
body
functions
age-related
diseases,
for
example,
Alzheimer's
disease,
which
adversely
affects
human
health
longevity.
The
quality
life
the
elderly
greatly
increase
their
expectancy
rather
healthy
expectancy.
With
rise
age
global
population,
aging
related
diseases
have
become
focus
attention
worldwide.
In
this
review,
we
discuss
several
major
mechanisms
aging,
including
damage
repair,
free
radical
oxidation,
telomeres
telomerase,
damage,
inflammation,
role
neurodegenerative
provide
reference
prevention
its
diseases.
ACS Applied Nano Materials,
Год журнала:
2020,
Номер
3(2), С. 2026 - 2037
Опубликована: Янв. 22, 2020
The
development
of
nanostructures
with
complementary
functionalities
has
emerged
as
a
prerequisite
for
more
efficient
preclinical
nanoparticle-mediated
thermo-therapeutic
research.
Here,
we
report
the
bimodal
application
manganese
doped-iron
oxide
nanoclusters
photothermal
and
magnetic
hyperthermia-mediated
glioblastoma
therapy.
Besides
combinatorial
effect,
have
also
explored
comparative
effects
single-mode
therapies
when
seldom
used
in
terms
cell
viability,
oxidative
stress
production,
reduction
mitochondrial
membrane
potential,
cytoskeletal
damage,
morphological
alterations.
In
all
aspects,
exposure
to
hyperthermia
was
shown
higher
therapeutic
effect
than
therapy
alone.
However,
it
is
ultimately
consequence
that
results
significant
death
rat
glioma
C6
cells.
Excitation
cells
laser
observed
create
cellular
environment
which
enhanced
efficiency
hyperthermia,
resulting
remarkable
anticancer
mediated
by
ROS-dependent
apoptosis
via
pathway.
Scientific Reports,
Год журнала:
2020,
Номер
10(1)
Опубликована: Апрель 3, 2020
Little
is
known
about
life
in
the
boron-rich
hot
springs
of
Trans-Himalayas.
Here,
we
explore
geomicrobiology
a
4438-m-high
spring
which
emanates
~70
°C-water
from
boratic
microbialite
called
Shivlinga.
Due
to
low
atmospheric
pressure,
vent-water
close
boiling
point
so
can
entropically
destabilize
biomacromolecular
systems.
Starting
vent,
Shivlinga's
was
revealed
along
thermal
gradients
an
outflow-channel
and
progressively-drying
mineral
matrix
that
has
no
running
water;
ecosystem
constraints
were
then
considered
relation
those
comparable
environments.
The
spring-water
chemistry
sinter
mineralogy
dominated
by
borates,
sodium,
thiosulfate,
sulfate,
sulfite,
sulfide,
bicarbonate,
other
macromolecule-stabilizing
(kosmotropic)
substances.
Microbial
diversity
high
both
hydrothermal
gradients.
Bacteria,
Eukarya
Archaea
constituted
>98%,
~1%
<1%
microbiome,
respectively.
Temperature
constrained
biodiversity
at
~50
°C
~60
°C,
but
not
below
46
°C.
Along
each
gradient,
vent-to-apron
trajectory,
communities
Aquificae/Deinococcus-Thermus,
Chlorobi/Chloroflexi/Cyanobacteria,
finally
Bacteroidetes/Proteobacteria/Firmicutes.
Interestingly,
sites
>45
inhabited
phylogenetic
relatives
taxa
for
laboratory
growth
highlights
possibility
system's
kosmotrope-dominated
mitigates
against
biomacromolecule-disordering
effects
its
water.
Advanced Therapeutics,
Год журнала:
2021,
Номер
4(7)
Опубликована: Май 13, 2021
Abstract
Heat
has
been
used
to
treat
tumors
for
thousands
of
years.
There
are
reports
the
Egyptians
and
Greek
philosophers
using
such
treatments
as
far
back
3000
BC
500
respectively
various
solid
tumors.
Albeit,
in
these
cases,
treatment
was
not
very
controlled
consisted
hot
sticks
or
blades
placed
against
tissue
order
thermally
ablate
tumor.
It
until
recent
times
that
application
heat
through
mediums
enabled
a
more
controlled,
localized,
consistent
method
treating
While
therapeutic
potential
this
become
apparent,
mechanisms
related
its
efficacy
only
recently
beginning
surface.
This
review
discusses
evidence
associated
with
effects
localized
on
hallmarks
cancer.
Key
literature
describing
modulations
vasculature,
cell
viability,
DNA
damage
repair,
metabolism,
immune
system,
tumor
metastasis
response
will
be
reviewed
along
considerations
optimal
implementation
clinic
enhance
conventional
treatments.
